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DISULFIRAM ICSC: 1438
Date of Peer Review: October 2002

Tetraethylthiuramdisulfide
1,1'-Dithiobis(N,N-diethylthioformamide)
bis-(N,N-Diethylthiocarbamoyl)disulfide
TETD
CAS # 97-77-8 C10H20N2S4 / ((C2H5)2NCS)2S2
RTECS # JO1225000 Molecular mass: 269.6
UN #
EC # 006-079-00-8
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Finely dispersed particles form explosive mixtures in air.
Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding).

EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!

Inhalation
Ventilation, local exhaust, or breathing protection.

Skin
Protective gloves.
Rinse skin with plenty of water or shower.
Eyes
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Confusion. Headache. Nausea. Vomiting.
Do not eat, drink, or smoke during work.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. Personal protection: P2 filter respirator for harmful particles.
EU Classification
Symbol: Xn, N
R: 22-43-48/22-50/53
S: (2-)-24-37-60-61
UN Classification

EMERGENCY RESPONSE SAFE STORAGE

Separated from strong oxidants.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2004

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DISULFIRAM ICSC: 1438
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
WHITE TO GREY POWDER, WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.

CHEMICAL DANGERS:
The substance decomposes on burning producing toxic and corrosive fumes including nitrogen oxides, sulfur oxides. Reacts violently with strong oxidants. Attacks copper.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 2 mg/m as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK: (Inhalable fraction) 2 mg/m; sensitization of skin (Sh); Peak limitation category: II(8); Pregnancy risk group: D; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of dust and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the endocrine system, liver, nervous system and thyroid, resulting in impaired functions. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
PHYSICAL PROPERTIES
Boiling point at 2.3kPa: 117C
Melting point: 71C
Density: 1.3 g/cm
Solubility in water, g/100 ml: 0.02
Octanol/water partition coefficient as log Pow: 3.9
ENVIRONMENTAL DATA
The substance is toxic to aquatic organisms.
NOTES
In combination with alcohol the substance causes effects on cardiovascular and central nervous systems resulting in palpitation, hypotension and hyperventilation. The effects may be delayed. Do NOT take working clothes home. Antabuse and Rosulfiram are trade names.
Card has been partly updated in April 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2004