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SECTION 1. CHEMICAL IDENTIFICATION

CHEMINFO Record Number: 731
CCOHS Chemical Name: o-Xylene

Synonyms:
1,2-Dimethylbenzene
o-Dimethylbenzene
2-Methyltoluene
1,2-Xylene
2-Xylene
o-Xylol
Xylene (non-specific name)

Chemical Name French: Xylène (ortho-)
Chemical Name Spanish: o-Xileno
CAS Registry Number: 95-47-6
UN/NA Number(s): 1307
RTECS Number(s): ZE2450000
EU EINECS/ELINCS Number: 202-422-2
Chemical Family: Aromatic hydrocarbon / alkylbenzene / dialkylbenzene
Molecular Formula: C8-H10
Structural Formula: CH3-C6H4-CH3

SECTION 2. DESCRIPTION

Appearance and Odour:
Clear, colourless liquid with a characteristic aromatic odour.

Odour Threshold:
5.4 ppm (detection) (12); 0.08-0.17 ppm (method not specified) (4).

Warning Properties:
GOOD - TLV is more than 10 times the odour threshold.

Composition/Purity:
o-Xylene is one of three chemical forms (isomers) of xylene (ortho-xylene, meta-xylene and para-xylene). o-Xylene is available commercially at about 99% purity. The information presented in this CHEMINFO record is given for o-xylene where available. Otherwise, information for the other isomers or the mixture of isomers is given.

Uses and Occurrences:
Xylene and the individual isomers are primarily man-made chemicals. Commercial xylene is produced from petroleum and coal tar. The mixture of xylene isomers also occurs naturally in small quantities in petroleum stacks, coal tar and natural gas and is formed during forest fires.(4,5) The individual isomers are separated from the mixed xylenes by various separation techniques.(5)
o-Xylene is used primarily as a raw material for the manufacture of phthalic anhydride; as a raw material for the production of plasticizers, alkyd resins and glass-enforced polyesters; as a chemical intermediate in the synthesis of dyes, vitamins, pharmaceuticals and insecticides; and in motor fuels.(5,11)


SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW:
Clear, colourless liquid with a characteristic aromatic odour. FLAMMABLE LIQUID AND VAPOUR. Liquid can accumulate static charge by flow or agitation. Vapour is heavier than air and may spread long distances. Distant ignition and flashback are possible. Liquid can float on water and may travel to distant locations and/or spread fire. Can decompose at high temperature forming toxic gases. Closed containers may rupture and explode in heat of fire. May cause lung injury -- effects may be delayed. Central nervous system depressant. High vapour concentrations may cause headache, nausea, dizziness, drowsiness, and confusion. Causes skin irritation. Aspiration hazard. Swallowing or vomiting of the liquid may result in aspiration into the lungs. Aspiration hazard. Swallowing or vomiting of the liquid may result in aspiration into the lungs.



POTENTIAL HEALTH EFFECTS

Effects of Short-Term (Acute) Exposure

Inhalation:
The main effect of inhaling o-xylene vapour is depression of the central nervous system (CNS), with symptoms such as headache, dizziness, nausea and vomiting. Irritation of the nose and throat can also occur. Extremely high concentrations (approximately 10000 ppm) could cause incoordination, loss of consciousness, respiratory failure and death. In some cases, a potentially fatal accumulation of fluid in the lungs (pulmonary edema) may result. Symptoms of pulmonary edema, such as shortness of breath and difficulty breathing, may be delayed several hours after exposure. However, these effects are rarely seen since o- xylene is irritating and identifiable by odour at much lower concentrations.(1,3) The only reported death resulted from exposure to xylenes (unspecified isomer composition and unknown concentration) in a confined space.(4,6) Reversible liver and kidney damage has been reported in cases of severe xylene exposure.(5,6)
Results of short-term studies on human volunteers indicate that xylenes can cause neurobehavioural effects such as impaired short- term memory and reaction time (300 ppm mixed xylenes, with exercise) and alterations in body balance (65 to 400 ppm m-xylene). Exposure to 300 or 400 ppm mixed xylenes with no exercise or 65 to 150 ppm p-xylene have not had similar effects. This variation in results is probably due to differences in the effects being studied, exposure conditions, development of tolerance and total xylene uptake (which increases during exercise).(4,16)

Skin Contact:
o-Xylene liquid is a severe skin irritant based on animal information. Studies with xylene isomers have shown irritation, redness and a burning sensation can result from contact. These effects are reversible shortly (1 hour) after the contact stops.(1,3,6) Application of 0.015 mL o-xylene for 5 to 10 minutes, under a covering, caused irritation which disappeared within 10 to 20 minutes.(3) Repeated or prolonged exposure to o-xylene can defat the skin resulting in dermatitis (red, dry, itchy skin).(6)
o-Xylene liquid or vapour can be absorbed through the skin, but not as readily as when inhaled or ingested.(1,16) Significant harmful effects are not expected by this route.

Eye Contact:
o-Xylene liquid is a very mild eye irritant, based on animal information.
Eye irritation has been reported at vapour levels of mixed xylenes as low as 200 ppm.(3) Corneal vacuoles (pockets of liquid or air in the cornea) have also been reported following exposure to undefined vapour concentrations. This effect was reversible within 8 to 11 days for 7 of 8 workers.(1,3)

Ingestion:
Based on animal information, o-xylene is only slightly toxic by ingestion. Ingestion of large amounts is likely to cause CNS effects such as dizziness, nausea and vomiting. In one case, ingestion of food probably contaminated with xylene (unspecified composition) caused pulmonary edema, liver impairment and coma. The man recovered within 2 hours after treatment.(6) Ingestion is not a common route of occupational exposure.
Although there are no case reports of aspiration, o-xylene may be aspirated, based on its physical properties (viscosity and surface tension). Aspiration is the inhalation of a material into the lungs during ingestion or vomiting. Severe lung irritation, damage to the lung tissues and death may result.

Effects of Long-Term (Chronic) Exposure

SKIN: Repeated contact can produce dermatitis (dryness and cracking) due to degreasing action.

SKIN SENSITIZATION: Skin sensitization was not produced in any of 24 volunteers.(1,3,6) There is one case report of a person developing an allergic skin reaction (contact urticaria) following exposure to xylene (unspecified composition) vapour. The person subsequently tested positive in a patch test. No information was provided regarding previous history of allergies.(8) No conclusions can be drawn regarding the potential for xylene to produce allergic skin reactions, based on this single case report.

NERVOUS SYSTEM EFFECTS: Long-term xylene exposure may cause harmful effects on the nervous system, but there is not enough information available to draw firm conclusions. Symptoms such as headaches, irritability, depression, insomnia, agitation, extreme tiredness, tremors, and impaired concentration and short-term memory have been reported following long-term occupational exposure to xylene and other solvents. This condition is sometime generally referred to as "organic solvent syndrome". Unfortunately, there is very little information available which isolates xylene from other solvent exposures in the examination of these chronic neurological effects. Other study deficiencies include inadequate reporting on the duration of exposure and exposure levels, and poor matching of controls.(3,4,6,16)
In a recent study, 175 employees were exposed to a mean xylene concentration of 21 ppm for an average of 7 years. Subjective symptoms such as anxiety, forgetfulness, inability to concentrate and dizziness were reported. Xylenes accounted for greater than 70% of the total exposure.(18) This study is also limited by factors such as those described above.

BLOOD EFFECTS: Historical reports sometimes associate xylene exposure with certain blood effects, including leukemia, which are now known to be caused by benzene. Uncontaminated xylene is not known to cause these effects.(1,4,6) Reduced blood platelet counts were observed in 12 of 27 men exposed to mixed xylenes (unspecified composition) at a level up to 200 ppm. When exposure stopped, platelet counts returned to normal.(3) There is insufficient information to draw any conclusions from this study.

LIVER AND KIDNEY EFFECTS: A number of case reports and occupational studies have suggested that liver and kidney damage may result from long-term occupational exposure to mixtures of xylene isomers. However, it is not possible to attribute these effects directly to xylene exposure because generally there was exposure to other chemicals at the same time, particularly other solvents, and there was no information provided on the exposure levels or duration of exposure.(3,4,16)
In a recent study, 175 employees were exposed to a mean xylene concentration of 21 ppm for an average of 7 years. Liver and kidney effects were not reported. Xylenes accounted for greater than 70% of the total exposure.(18)

Carcinogenicity:

Xylene has been mentioned as an exposure in 4 case-control studies. Cancers at most sites were not significantly associated with xylene exposure in any study. Most results were based on small numbers, most studies involved exposure to other potentially harmful substances, and the consistency of findings is weak. Therefore, the International Agency for Research on Cancer (IARC) has concluded that there is inadequate evidence for carcinogenicity of xylene in humans.(5,20)

The International Agency for Research on Cancer (IARC) has concluded that this chemical is not classifiable as to its carcinogenicity to humans (Group 3).

The American Conference of Governmental Industrial Hygienists (ACGIH) has designated this chemical as not classifiable as a human carcinogen (A4).

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
There is insufficient information available to conclude that o-xylene causes developmental toxicity. Although, one animal study does suggest that mild fetotoxicity (reduced body weight) may occur in the absence of maternal toxicity. Other animal studies have shown developmental effects following exposures that have caused toxicity in the mothers.
Several human population studies have suggested a link between exposure to organic solvents (including xylene) and increased occurrence of miscarriages or birth defects in children. However, in the majority of cases there was exposure to a variety of solvents at the same time, exposures were ill-defined, and the number of cases was small.(3,4,5,6)
Mixed xylenes, which contain m-, o- and p-xylene and ethylbenzene, are fetotoxic, in the absence of maternal toxicity. Refer to the CHEMINFO review of "xylene, mixed isomers" for additional information.

Reproductive Toxicity:
An increase in menstrual disorders has been reported in women exposed to organic solvents such as benzene, toluene and xylenes.(6) It is not possible to attribute these effects to xylenes in particular. The limited animal information available suggests that o-xylene does not cause reproductive effects.

Mutagenicity:
There have been a few studies investigating the mutagenic potential of xylenes in man. Although the results of these studies have largely been negative, no conclusions can be drawn because of limitations such as small study population and exposure to other chemicals at the same time.(3,4,5,20) Negative results were also obtained in 5 volunteers exposed for 3 days to 40 ppm xylene.(20) o-Xylene (by injection) gave negative results in two tests using live animals.(3,4,5)

Toxicologically Synergistic Materials:
Exposure to related solvents, such as benzene, toluene and ethanol (alcohol) slows the rate of clearance of xylenes from the body, thus enhancing its toxic effects.(4) Exposure to xylene in combination with other solvents has had an additive effect with respect to harming hearing in rats.(19)

Potential for Accumulation:
o-Xylene is readily absorbed by inhalation and ingestion and is widely distributed throughout the body. A small amount may be absorbed through the skin. It is largely broken down by the liver and most of the absorbed material is rapidly excreted in the urine as breakdown products. Smaller amounts are eliminated unchanged in the exhaled air.(1,3,4,16) There is low potential for accumulation.


SECTION 4. FIRST AID MEASURES

Inhalation:
This product is flammable. Take proper precautions (e.g. remove any sources of ignition. Remove source of contamination or move victim to fresh air. If breathing is difficult, oxygen may be beneficial if administered by trained personnel, preferably on a doctor's advice. DO NOT allow the victim to move about unnecessarily. Symptoms of pulmonary edema can be delayed up to 48 hours after exposure. Immediately transport victim to an emergency care facility.

Skin Contact:
As quickly as possible, remove contaminated clothing, shoes and leather goods (e.g. watchbands, belts). Quickly and gently blot or brush away excess chemical. Wash gently and thoroughly with water and non-abrasive soap for at least 20 minutes or until chemical is removed. Obtain medical advice immediately. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
Quickly and gently blot or brush away excess chemical. Immediately flush the contaminated eye(s) with lukewarm, gently flowing water for 5 minutes or until the chemical is removed, while holding the eyelid(s) open. Obtain medical advice immediately.

Ingestion:
NEVER give anything by mouth if victim is rapidly losing consciousness, is unconscious or is convulsing. DO NOT INDUCE VOMITING. Have victim drink 240 to 300 mL (8 to 10 ozs) of water to dilute material in stomach. If vomiting occurs naturally, have victim lean forward to reduce risk of aspiration. Repeat administration of water. Obtain medical attention immediately.

First Aid Comments:
Provide general supportive measures (comfort, warmth, rest). Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.
Some recommendations in the above sections may be considered medical acts in some jurisdictions. These recommendations should be reviewed with a doctor and appropriate delegation of authority obtained, as required.
All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.



SECTION 5. FIRE FIGHTING MEASURES

Flash Point:
17 deg C (63 deg F) (closed cup) (4); also reported as 32 deg C (90 deg F) (closed cup) (3,4,5)

Lower Flammable (Explosive) Limit (LFL/LEL):
0.9% by volume (13)

Upper Flammable (Explosive) Limit (UFL/UEL):
6.7% by volume (13)

Autoignition (Ignition) Temperature:
463 deg C (867 deg F) (13)

Sensitivity to Mechanical Impact:
Stable material; probably not sensitive.

Sensitivity to Static Charge:
There is no specific information available. Liquid can accumulate static charge by flow or agitation. Vapour can be ignited by a static discharge.

Combustion and Thermal Decomposition Products:
Reactive hydrocarbons, aldehydes.

Fire Hazard Summary:
Flammable liquid. Can release vapours that form explosive mixtures with air at, or above 17 deg C. Liquid can accumulate static charge by flow or agitation. Vapour can be ignited by static discharge. Vapour is heavier than air and may travel a considerable distance to a source of ignition and flash back to a leak or open container. Liquid can float on water and may travel to distant locations and/or spread fire. During a fire, irritating/toxic gases may be generated. Can accumulate in confined spaces, resulting in a toxicity and flammability hazard. Containers may explode in heat of fire.

Extinguishing Media:
Carbon dioxide, dry chemical powder, foam, water spray or fog. Water may be ineffective, since it may not cool o-xylene below its flash point. Firefighting foams are the extinguishing agent of choice for most flammable liquid fires.

Fire Fighting Instructions:
Evacuate area and fight fire from a safe distance or a protected location. Approach fire from upwind to avoid hazardous vapours and toxic decomposition products.
Stop leak before attempting to put out the fire. If the leak cannot be stopped, and if there is no risk to the surrounding area, let the fire burn itself out. If the flames are extinguished without stopping the leak, vapours could form explosive mixtures with air and reignite.
Water can extinguish the fire if used under favourable conditions and when hose streams are applied by experienced firefighters trained in fighting all types of flammable liquid fires. If possible, isolate materials not yet involved in the fire, and move containers from fire area if this can be done without risk, and protect personnel. Otherwise, fire-exposed containers or tanks should be cooled by application of hose streams and this should begin as soon as possible and should concentrate on any unwetted portions of the container. If this is not possible, used unmanned monitor nozzles and immediately evacuate the area. If a leak or spill has not ignited, use water spray in large quantities to disperse the vapours and to protect personnel attempting to stop the leak. Water spray can be used to flush spills away from ignition sources. Solid streams of water may be ineffective and spread the material.
For a massive fire in a large area, use unmanned hose holder or monitor nozzles. If this is not possible, withdraw from fire area and allow fire to burn. Stay away from ends of tanks. Be aware that flying material from ruptured tanks can travel in any direction. Withdraw immediately in case of rising sound from venting safety device or any discolouration of tank due to fire.
Do not enter without wearing specialized protective equipment suitable for the situation. Firefighter's normal protective clothing (Bunker Gear) will not provide adequate protection. Chemical resistant clothing (e.g. chemical splash suit) and positive pressure self-contained breathing apparatus (MSHA/NIOSH approved or equivalent) may be necessary.



NATIONAL FIRE PROTECTION ASSOCIATION (NFPA) HAZARD IDENTIFICATION

NFPA - Health: 2 - Intense or continued (but not chronic) exposure could cause temporary incapacitation or possible residual injury.
NFPA - Flammability: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions.
NFPA - Instability: 0 - Normally stable, even under fire conditions, and not reactive with water.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Molecular Weight: 106.16

Conversion Factor:
1 ppm = 4.33 mg/m3; 1 mg/m3 = 0.23 ppm at 25 deg C (calculated)

Physical State: Liquid
Melting Point: -25 deg C (-13 deg F) (4)
Boiling Point: 144 deg C (291 deg F) (3,4,5)
Relative Density (Specific Gravity): 0.880 (water = 1) (3,4,5)
Solubility in Water: Practically insoluble (178-213 mg/L) at 25 deg C (4)
Solubility in Other Liquids: Soluble in all proportions in ethyl alcohol, diethyl ether, acetone and benzene (4,11)
Coefficient of Oil/Water Distribution (Partition Coefficient): Log P(oct) = 2.77 (1,4); Log P(oct) = 3.12 (3,4,5)
pH Value: Not applicable
Vapour Density: 3.7 (air = 1)
Vapour Pressure: 0.667 kPa (5.0 mm Hg) at 20 deg C (3,4); 0.907 kPa (6.8 mm Hg) at 25 deg C (5)
Saturation Vapour Concentration: 6580 ppm (0.66%) at 20 deg C; 8950 ppm (0.89%) at 25 deg C (calculated)
Evaporation Rate: 9.2 (diethyl ether = 1) (11)
Critical Temperature: 359 deg C (678 deg F) (11)

Other Physical Properties:
VISCOSITY-DYNAMIC: 0.76 centipoises (0.76 mPa.s) at 25 deg C (11)
VISCOSITY-KINEMATIC: 0.864 m2/s (0.920 centistokes) at 20 deg C (calculated)
SURFACE TENSION: 29.76 dynes/cm at 25 deg C (11)
CRITICAL PRESSURE: 3710 kPa (36.6 atmospheres) (11)


SECTION 10. STABILITY AND REACTIVITY

Stability:
Normally stable to heat, light and air.

Hazardous Polymerization:
Does not occur.

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.


STRONG OXIDIZING AGENTS - Increased risk of fire and explosion.(14)
NITRIC ACID, DICHLOROHYDRANTOIN - Reaction can be explosive.(14)

Hazardous Decomposition Products:
None reported.

Conditions to Avoid:
Static discharge, sparks, open flames, heat, other ignition sources.

Corrosivity to Metals:
Not corrosive to metals.

Stability and Reactivity Comments:
Xylene will attack some forms of plastics, rubber and coatings.


SECTION 11. TOXICOLOGICAL INFORMATION

LC50 (rat): 5300 ppm (4-hour exposure); cited as 4330 ppm (6-hour exposure) (3)
LC50 (mouse): 5630 ppm (4-hour exposure); cited as 4595 ppm (6-hour exposure) (3,4)

LD50 (oral, rat): 3608 mg/kg (3,16)

LD50 (dermal, rabbit): 20000 mg/kg (3)

Eye Irritation:

o-Xylene is a very mild eye irritant.

Application of 0.1 mL of undiluted o-xylene caused very mild irritation in rabbits (average score for 24, 48 and 72 hours 6.9/110). All scores were 0/110 by day 7.(23) Vapour exposure (unknown concentration) to mixed xylenes (undefined composition) resulted in fine vacuoles in the corneas of cats, which disappeared in 24 hours.(3)

Skin Irritation:

o-Xylene is a severe skin irritant.

Application of 0.5 mL undiluted o-xylene for 24 hours caused severe skin irritation in rabbits (average score at 24, 48 and 72 hours 6.2/8). There was no in-depth injury.(23) Application of 0.5 mL of undiluted o-xylene, under cover, to rabbit skin for 4 hours has been reported to cause irritation (defined as an average score for redness at 24, 48 and 72 hours of 2/4 or higher). A score of less than 2/4 for redness was obtained for a 50% solution in almond oil.(22) In an unpublished study, application of o-xylene (amount unspecified, but described as low) to rabbit skin for 24 hours, under cover, caused redness and swelling while higher amounts cause fissuring.(3, unconfirmed)

Effects of Short-Term (Acute) Exposure:

Inhalation:
As with mixed xylenes, the major effect of o-xylene is on the central nervous system (CNS). There is initial excitation at concentrations above 1400 ppm followed by depression, drowsiness, incoordination and unconsciousness at approximately 2000 ppm. Death at higher concentrations is from respiratory failure due to CNS depression and accumulation of fluid in the lungs. Irritation of the respiratory tract, causing a decrease in the respiratory rate, has been reported. The RD50, the concentration which causes a 50% decrease in the respiratory rate of mice, is 1467 ppm.(1,3,4) This concentration is expected to produce intolerable eye, nose and throat irritation (sensory irritation) in humans. Behavioral effects such as effects on learned behaviours and avoidance conditioning have been observed in animals following short-term inhalation.(4,16) Hearing loss, mainly at mid-frequencies, has been documented in rats following short-term exposures (800 ppm and above for 6 weeks or 1450 ppm for 3 days) to mixed xylenes (80% m-, 10% o-, 10% p-). A no-effect level was not determined and reversibility was not assessed.(3,4,16) There is no specific information available for o-xylene.

Effects of Long-Term (Chronic) Exposure:

In general, animal studies of o-xylene and mixtures of xylene isomers have provided no significant evidence of damage to the liver, kidney or lungs nor any other significant long-term health effects.(3,16) No mortality or toxicologically important findings were reported in rats following exposure to 3500 ppm o-xylene, 8 hours/day for one to 6 weeks. Xylenes have not been shown to cause benzene-like cancer of the blood.(1,4)

Carcinogenicity:
The International Agency for Research on Cancer (IARC) has determined that there is inadequate evidence for the carcinogenicity of o-xylene to experimental animals.(5,20)
There is no specific information available on o-xylene. Oral studies of mixed xylenes (60.2% m-, 9.1% o-, 13.6% p- , 17% ethylbenzene) in rats (up to 500 mg/kg for 103 weeks) and mice (up to 1000 mg/kg for 103 weeks) found no treatment-related increase in the incidence of tumours.(5) In another carcinogenicity study, mixed xylenes (unspecified composition) were administered to rats (up to 500 mg/kg for 104 weeks). The reporting of this study was so poor that it is not possible to evaluate the results. A number of studies have investigated whether exposure to xylenes causes skin cancer. The conduct and reporting of these studies do not allow any conclusions to be drawn.(3)

Teratogenicity, Embryotoxicity and/or Fetotoxicity:
One study has shown slight fetotoxicity (reduced weight) in the offspring of rats at a concentration that did not cause maternal toxicity. Higher exposures have produced fetotoxicity and embryotoxicity. Mixed xylenes, which contain m-, o- and p-xylene and ethylbenzene, are fetotoxic, in the absence of maternal toxicity. Refer to the CHEMINFO review of "xylene, mixed isomers" for additional information.
The offspring of rats exposed to 0, 100, 500, 1000 or 2000 ppm o-xylene from days 6-20 of pregnancy (6 hr/d) showed increased skeletal abnormalities at 2000 ppm. Fetal body weights were significantly reduced at 500, 1000 and 2000 ppm. Maternal toxicity (reduced body weight gain and food consumption) was observed at 1000 and 2000 ppm. Clinical signs of toxicity were observed at 2000 ppm.(21) Embryotoxicity and fetotoxicity were observed in the offspring of rats and mice exposed orally or by inhalation to concentrations that also produced significant harmful effects in the mothers.(6,17) No conclusions can be drawn from other studies because of significant design limitations for example, poor reporting of exposure details and/or effects and inadequate evaluation of maternal toxicity.(3,6,16,17)

Reproductive Toxicity:
There is no specific information available on o-xylene. No harmful reproductive effects were noted in males or females when rats were exposed to up to 500 ppm mixed xylenes (44.2% m-, 20.4% o-, 20.3% p-, 12.8% ethylbenzene) in a single generation study.(3,4) No firm negative conclusions can be drawn from this study because the maximum tolerated dose may not have been achieved. Ingestion of mixed xylenes for up to 2 years caused no observable harmful effects in the reproductive organs of male and female rats (up to 500 mg/kg/day) or mice (up to 1000 mg/kg/day).(4)

Mutagenicity:
Mutagenicity tests on bacteria (Salmonella typhimurium) have been negative. A micronucleus assay in the bone marrow of mice, injected with 2 doses of up to 440 mg/kg and a sperm head abnormality assay in rats, injected with 440 or 1300 mg/kg, were also negative.(3,4,5,16) Negative results have also consistently been obtained for mixed xylenes.(4,20)


SECTION 16. OTHER INFORMATION

Selected Bibliography:
(1) Low, K., et al. Health effects of the alkylbenzenes. II. Xylenes. Toxicology and Industrial Health. Vol. 5, no. 1 (1989). p. 85-105
(2) Carpenter, C.P., et al. Petroleum hydrocarbon toxicity studies. V. animal and human response to vapors of mixed xylenes. Toxicology and Applied Pharmacology. Vol. 33 (1975). p. 543-558
(3) Bell, G.M., et al. Xylenes. Toxicity Review 26. UK Health and Safety Executive, 1992
(4) Agency for Toxic Substances and Disease Registry. Toxicological profile for xylenes (update). US Department of Health and Human Services, 1995
(5) IARC Monographs on the evaluation of carcinogenic risks to humans. Vol. 47. World Health Organization, 1989. p. 125-156
(6) Xylenes. Joint assessment of commodity chemicals: No. 6. European Chemical Industry Ecology and Toxicology Centre, June 1986
(7) Wolf, M.A., et al. Toxicological studies of certain alkylated benzenes and benzene. AMA Archives of Industrial Health. Vol. 14 (1956). p. 387-398
(8) Palmer, K.T., et al. Occupational airborne contact urticaria due to xylene. Contact Dermatitis. Vol. 28, no. 1 (1993). p. 44
(9) NIOSH pocket guide to chemical hazards. National Institute for Occupational Safety and Health, June 1997
(10) Forsberg, K., et al. Quick selection guide to chemical protective clothing. 4th ed. Van Nostrand Reinhold, 2002
(11) HSDB database record for 2-xylene. Date of last update: 9706
(12) Odor thresholds for chemicals with established occupational health standards. American Industrial Hygiene Association, 1989. p. 30, 80
(13) Fire protection guide to hazardous materials. 13th ed. Edited by A.B. Spencer, et al. National Fire Protection Association, 2002. NFPA 325
(14) Urben, P.G., ed. Bretherick's handbook of reactive chemical hazards. 5th ed. Vol. 1. Butterworth-Heinemann Ltd., 1995. p. 961-962
(15) European Communities. Commission Directive 98/98/EC. Dec. 15, 1998
(16) International Programme on Chemical Safety (IPCS). Xylenes. Environmental Health Criteria 190. World Health Organization, 1997
(17) Hood, R.D., et al. Developmental effects associated with exposure to xylene: a review. Drug and Chemical Toxicology. Vol. 8, no. 4 (1985). p. 281-297
(18) Uchida, Y., et al. Symptoms and signs in workers exposed predominantly to xylenes. International Archives of Occupational and Environmental Health. Vol. 64 (1993). p. 597-605
(19) Rebert, C.S., et al. Combined effects of paired solvents on the rat's auditory system. Toxicology. Vol. 105, nos. 2/3 (1995). p. 345-354
(20) International Agency for Research on Cancer (IARC). IARC monographs on the evaluation of carcinogenic risks to humans. Vol. 71, parts 1, 2 and 3. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. IARC, 1999
(21) Saillenfait, A.M., et al. Developmental toxicities of ethylbenzene, orth-, meta- para-xylene and technical xylene in rats following inhalation exposure. Food and Chemical Toxicology. Vol. 41, no. 3 (Mar. 2003). p. 415-429
(22) Jacobs, G., et al. Proposal of limit concentrations for skin irritation within the context of a new EEC directive on the classification and labeling of preparations. Regulatory Toxicology and Pharmacology. Vol. 7, no. 4 (Dec. 1987). p. 370-8.
(23) Younger Laboratories. Summary of acute oral and dermal toxicity studies using 95-47-6. Monsanto Company. Date produced: Sept. 1978. EPA/OTS 40-7842788. NTIS/OTS0519455.

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.


Review/Preparation Date: 1998-03-23

Revision Indicators:
Carcinogenicity 1999-12-01
Mutagenicity 1999-12-01
TDG 2002-05-29
PEL transitional comments 2003-12-19
PEL-TWA final 2003-12-19
PEL-STEL final 2003-12-19
Resistance of materials for PPE 2004-04-06
Teratogenicity/embryotoxicity 2004-06-17
Bibliography 2006-02-17
Toxicological info 2006-02-21
Short-term skin contact 2006-02-21
Short-term eye contact 2006-02-21
WHMIS detailed classification 2006-02-21



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