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CHEMINFO Record Number: 165
CCOHS Chemical Name: Tripropylene glycol monomethyl ether

Tripropylene glycol methyl ether
Ether monomethylique du tripropyléneglycol

Trade Name(s):
Arcosolv TPM
Dowanol TPM glycol ether
Glycol ether TPM

CAS Registry Number: 25498-49-1
Other CAS Registry Number(s): 20324-33-8 10213-77-1
RTECS Number(s): UB8050000 UB8070000 UB7875900
Chemical Family: Aliphatic ether alcohol / aliphatic glycol ether / aliphatic triglycol ether / aliphatic triglycol mono ether / propylene glycol ether / tripropylene glycol monoether
Molecular Formula: C10-H22-O4
Structural Formula: CH3-O-C3H6-O-C3H6-O-C3H6-OH


Appearance and Odour:
Clear, colourless liquid with a slight sweetish ether odour.(1,3)

Odour Threshold:
No information available

Warning Properties:
No information available for evaluation.

Commercially available as "pure" tripropylene glycol monomethyl ether (TPGME) or as mixtures with propylene glycol monomethyl ether and/or dipropylene glycol monomethyl ether. Commercial TPGME is a mixture of a number of closely related chemical forms (isomers), the main ones being 1-(2-(2-methoxy-1-methylethoxy)-1-methylethoxy)-2-propanol (CAS no. 203-24-33-8), (2-(2-methoxymethyl ethoxy)methyl ethoxy) propanol (CAS no. 25498-49-1) and 2-(2-(2-methoxy propoxy)propoxy)-1-propanol (CAS no. 10213-77-1).

Uses and Occurrences:
TPGME is a high-boiling solvent for paints, lacquers, resins, dyes, oils, greases, cleaners and cellulose; component of hydraulic brake fluids. TPGME is frequently chosen as a substitute for the more toxic triethylene glycol methyl ether.


Clear, colourless liquid with a slight sweetish odour. Little or no hazard if spilled. Can probably burn if strongly heated. High mist concentrations may be irritating to respiratory tract.


Effects of Short-Term (Acute) Exposure

No human data is available. The irritant effects of related compounds, propylene glycol monomethyl ether (PGME) and dipropylene glycol monomethyl ether (DPGME) occur at levels above 100 ppm; effects on the central nervous system (narcosis) occur at around 1000 ppm. Since vapour concentrations of tripropylene glycol monomethyl ether (TPGME) cannot exceed about 30 ppm at room temperature, no irritating or other toxic effects would be expected by inhalation of vapour alone under normal conditions.

High concentrations of TPGME mists can irritate the nose and throat and cause nausea, headache, dizziness, weakness and fatigue and other effects of central nervous system depression.

Skin Contact:
No human data available. Based on human data for DPGME and animal data for TPGME, no skin irritation or sensitization is expected.

Based on the low toxicity in acute animal skin absorption studies, TPGME is unlikely to produce toxic effects with normal use and handling. Acute toxicity would probably be indicated by effects on the central nervous system such as headache, nausea, light-headedness, drowsiness, incoordination or possibly unconsciousness.

Eye Contact:
Based on animal data, liquid TPGME is expected to be only a mild irritant to the eyes.

The low oral toxicity in animal studies indicates practically no likelihood that toxic amounts would be swallowed in ordinary handling and use. Although no cases of ingestion have been reported, the expected effects could include irritation, nausea, vomiting and diarrhea.

Effects of Long-Term (Chronic) Exposure

There are no reported cases of chronic effects in humans.

SKIN: Chronic animal studies indicate that TPGME is absorbed through the skin. It can cause some kidney injury following extensive long-term exposure. Such injury is unlikely from occupational exposure.

Repeated or prolonged skin contact may cause irritation, drying of skin and dermatitis.


No human or animal information is available

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
No human or animal information is available. Animal tests on the chemically-related PGME showed no significant effects.

Reproductive Toxicity:
No human or animal information is available

No human or animal information is available. Negative results were obtained in short-term bacterial tests.(4)

Toxicologically Synergistic Materials:
No information is available

Potential for Accumulation:
Based on the related propylene glycol ethers, PGME and DPGME, TPGME is probably readily absorbed by inhalation, dermal and oral routes, but is unlikely to accumulate.

Health Comments:
The limited data available for TPGME indicates relatively low toxicity by all routes.


If symptoms are experienced, remove source of contamination or move victim to fresh air. Obtain medical advice immediately.

Skin Contact:
As quickly as possible, flush with lukewarm, gently flowing water for at least 5 minutes or until the chemical is removed. Under running water, remove contaminated clothing, shoes and leather goods (e.g. watchbands, belts). If irritation persists, repeat flushing. Obtain medical advice immediately. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
If irritation occurs, immediately flush the contaminated eye(s) with lukewarm, gently flowing water for at least 5 minutes, or until the chemical is removed, while holding the eyelid(s) open. If irritation persists, obtain medical advice immediately.

Never give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. DO NOT INDUCE VOMITING. Have victim drink 240 to 300 mL (8 to 10 oz.) of water. If vomiting occurs naturally, rinse mouth and repeat administration of water. Obtain medical advice immediately.

First Aid Comments:
Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.
All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.


Flash Point:
121 deg C (250 deg F) (closed cup) (6); 126.7 deg C (260 deg F) (Cleveland open cup (5)

Lower Flammable (Explosive) Limit (LFL/LEL):
Not available

Upper Flammable (Explosive) Limit (UFL/UEL):
Not available

Autoignition (Ignition) Temperature:
Not available

Sensitivity to Mechanical Impact:
Probably not sensitive. Stable material.

Sensitivity to Static Charge:
Probably not sensitive. Not combustible.

Fire Hazard Summary:
This material can probably burn if strongly heated.

Extinguishing Media:
Carbon dioxide, dry chemical powder, alcohol foam, polymer foam. Water spray or foam may cause frothing.

Fire Fighting Instructions:
Water spray or fog or alcohol foam can be used to extinguish fires involving tripropylene glycol monomethyl ether (TPGME). Water or foam may cause frothing. However, a water spray or fog that is gently applied to the surface of the liquid, preferably with a fine spray or fog nozzle, will cause frothing that will blanket and extinguish the fire.
Water spray or mist can be used to absorb heat, keep containers cool and protect exposed material. If a leak or spill has not ignited, use water spray to disperse the vapours, dilute the spill to a nonflammable mixture, and to protect personnel attempting to stop a leak. Water spray may be used to flush spills away from ignition sources.

Protection of Fire Fighters:
TPGME is practically nonhazardous to health. Firefighters may enter the area if positive pressure self-contained breathing apparatus (NIOSH approved or equivalent) and full Bunker Gear is worn.


NFPA - Health: 1 - Exposure would cause significant irritation, but only minor residual injury.
NFPA - Flammability: 1 - Must be preheated before ignition can occur.
NFPA - Instability: 0 - Normally stable, even under fire conditions, and not reactive with water.


Molecular Weight: 206.32

Conversion Factor:
1 ppm = 8.42 mg/m3; 1 mg/m3 = 0.119 ppm at 25 deg C (calculated)

Physical State: Liquid
Melting Point: -60 deg C (-76 deg F) (Freezing point)
Boiling Point: 243 deg C (470 deg F) (3)
Relative Density (Specific Gravity): 0.967 at 25 deg C (water = 1) (3,5)
Solubility in Water: Soluble in all proportions (3)
Solubility in Other Liquids: Soluble in all proportions in acetone, ethanol, benzene, carbon tetrachloride, ether, methanol, monochlorobenzene and VM&P naphtha.
Coefficient of Oil/Water Distribution (Partition Coefficient): Not available
pH Value: Not available
Vapour Density: 7.12 (air = 1 (6)
Vapour Pressure: 0.002 kPa (0.017 mm Hg) at 25 deg C
Saturation Vapour Concentration: Approximately 0.003% (30 ppm) at 25 deg C (calculated)
Evaporation Rate: Not available
Critical Temperature: Not available

Other Physical Properties:
VISCOSITY-KINEMATIC: 6.16 centistokes at 25 deg C (5)


Normally stable

Hazardous Polymerization:
Will not occur

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.

OXIDIZING AGENTS - may increase risk of fire and explosion.

Hazardous Decomposition Products:
None reported

Conditions to Avoid:
Temperatures above 121 deg C

Corrosivity to Metals:
Not corrosive

Stability and Reactivity Comments:
Some glycol ethers can form peroxides during prolonged storage in contact with air. Formation of peroxides occur more readily in sunlight. Peroxides may be flammable and explosive. The rate and extent of peroxide formation with TPGME is unknown but is expected to be low. This is not expected to pose any hazard.


LD50 (oral, rat): 3.3 g/kg (1,3)
LDLO (oral, dog): 4.8 g/kg (5 mL/kg) (1)

EYE IRRITATION (rabbit): Repeated doses (5 days) produced mild temporary irritation with no corneal injury.(3)

SKIN IRRITATION (rabbit): Repeated application (65/90 days) produced only very mild irritation, similar to that produced by water.(1,3)

SKIN ABSORPTION (rabbit): Large repeated doses (10 mL/kg, 5 days/week, 90 days produced narcosis, kidney injury and death. Some of the rabbits surviving the larger doses, developed a tolerance for the material. There was slight kidney injury at lower dosage levels (1.0 mL/kg and 3.0 mL/kg). The liver, lungs, heart, adrenals, spleen, testes and stomach were all within normal limits.(3)

The primary effect is central nervous system depression with death from large doses due to respiratory failure.(1) Doses up to 20 mL/kg for 24 hrs produced only 1 death/18 animals. Recovery was longer than for PGME or The primary effect is central nervous system depression with death from large doses due to respiratory failure.(1) DPGME.

MUTAGENICITY: Tripropylene glycol monomethyl ether gave negative results in short-term bacterial tests.(4)


Selected Bibliography:
(1) Patty's industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. John Wiley & Sons, 1982. p. 3975, 3994-3996
(2) Langhorst, M. Glycol ethers - validation procedures for tube/pump and dosimeter monitoring methods. American Industrial Hygiene Association Journal. Vol. 45, no. 6 (1984). p. 416-424
(3) Rowe, V.K., et al. Toxicology of mono-, di-, and tri-propylene glycol methyl ethers. Archives of Industrial Hygiene and Occupational Medicine. Vol. 9 (1954). p. 509-525
(4) The toxicology of glycol ethers and its relevance to man: an up-dating of ECETOC technical report no. 4 (technical report no. 17). ECETOC, 1985
(5) Industrial solvents handbook. 3rd ed. Noyes Data Corporation, 1985. p. 434
(6) Fire protection guide to hazardous materials. 13th ed. Edited by A.B. Spencer, et al. National Fire Protection Association, 2002. NFPA 325

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.

Review/Preparation Date: 1993-03-02

Revision Indicators:
TDG 1994-03-01
Fire fighting instructions 1995-01-01
Conditions to avoid 1995-01-01
EU class 1995-10-01
US transport 1995-10-01
Protective equipment 1995-10-01
Sampling 1996-01-01
Resistance of materials 1998-05-01
Bibliography 2003-03-25
NFPA (health) 2003-03-25
WHMIS disclosure list 2003-05-30
Carcinogenicity 2003-05-30
PEL-TWA transitional 2003-10-16

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