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CHEMINFO Record Number: 173
CCOHS Chemical Name: Tripropylene glycol monoethyl ether

Tripropylene glycol ethyl ether
Ether monoéthylique du tripropylèneglycol

CAS Registry Number: 20178-34-1
RTECS Number(s): YK7175000
Chemical Family: Aliphatic ether alcohol / aliphatic glycol ether / aliphatic triglycol ether / aliphatic triglycol mono ether / propylene glycol ether / tripropylene glycol / monoether
Molecular Formula: C11-H24-O4
Structural Formula: CH3-CH(OH)-CH2-O-CH(CH3)-CH2-O-CH(CH3)-CH2-O-CH2-CH3


Appearance and Odour:
Clear colourless liquid with slight, pleasant, ether-like (sweet) odour

Odour Threshold:
No information available

Warning Properties:
No information available for evaluation

Uses and Occurrences:
Propylene glycol ethers have diverse solvent applications including paints, lacquers, resins, inks, dyes, oils/greases and cleaners. They are frequently chosen as substitutes for the more toxic ethylene glycol ethers.


Clear, colourless liquid with a slight, pleasant ether-like odour. Can probably burn if strongly heated. High mist concentrations may be irritating to respiratory tract.


Effects of Short-Term (Acute) Exposure

For chemically-related materials, such as propylene glycol monomethyl ether (PGME), and dipropylene glycol monomethyl ether (DPGME), irritant effects occurred at approximately 100 ppm and central nervous system depression (PGME) at about 1000 ppm.

Tripropylene glycol monoethyl ether (TPGEE) has a low tendency to form vapours (maximum concentration of about 25 ppm at room temperature). Thus, these toxic effects would not be expected unless high concentrations of mists are formed.

Skin Contact:
Animal testing indicates that TPGEE is unlikely to be irritating to skin. There are no reports of irritation or sensitization from contact with this or other members of this chemical family.

Propylene glycol ethers are readily absorbed through the skin. However, due to their apparent low toxicity, severe contact would be required to produce toxic effects. Extensive or prolonged contact might cause depression of the central nervous system marked by headache, nausea, light-headedness, drowsiness, incoordination or possible unconsciousness.

Eye Contact:
Based on animal testing, direct contact with TPGEE may cause mild irritation but no injury.

The low oral toxicity in animal studies indicates that it is unlikely that toxic amounts would be ingested with normal handling and use. Although no cases of ingestion have been reported, the main toxic effect would be depression of the central nervous system.

Effects of Long-Term (Chronic) Exposure

There are no reported studies of effects of long-term exposure to TPGEE in animals or humans.


No human or animal information is available

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
No human or animal information is available

Reproductive Toxicity:
No human or animal information is available

No information is available

Toxicologically Synergistic Materials:
No information is available

Potential for Accumulation:
Based on what is known about other propylene glycol ethers, TPGEE is probably readily absorbed by inhalation, dermal and oral routes, but is unlikely to accumulate in the body.

Health Comments:
The limited data available for TPGEE indicate relatively low toxicity. Under normal conditions of use, the hazards are expected to be minimal; however, it is best to minimize contact/exposure until more information is available.


If symptoms are experienced, remove source of contamination or move victim to fresh air. Obtain medical advice immediately.

Skin Contact:
As quickly as possible, flush with lukewarm, gently flowing water for at least 5 minutes or until the chemical is removed. Under running water, remove contaminated clothing, shoes and leather goods (e.g. watchbands, belts). If irritation persists, repeat flushing. Obtain medical advice immediately. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
If irritation occurs, immediately flush the contaminated eye(s) with lukewarm, gently flowing water for at least 5 minutes, or until the chemical is removed, while holding the eyelid(s) open. If irritation persists, obtain medical advice immediately.

Never give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. DO NOT INDUCE VOMITING. Have victim drink 240 to 300 mL (8 to 10 oz.) of water. If vomiting occurs naturally, rinse mouth and repeat administration of water. Obtain medical advice immediately.

First Aid Comments:
Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.
All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.


Flash Point:
132 deg C (270 deg F) (Cleveland open cup) (2)

Lower Flammable (Explosive) Limit (LFL/LEL):
Not available

Upper Flammable (Explosive) Limit (UFL/UEL):
Not available

Autoignition (Ignition) Temperature:
Not available

Sensitivity to Mechanical Impact:
Probably not sensitive. Stable material.

Sensitivity to Static Charge:
Probably not sensitive. Not combustible.

Fire Hazard Summary:
This material can probably burn if strongly heated.

Extinguishing Media:
Carbon dioxide, dry chemical powder, alcohol foam, polymer foam. Water spray may cause frothing.

Fire Fighting Instructions:
Water spray or fog or alcohol foam can be used to extinguish fires involving tripropylene glycol monoethyl (ether/TPGEE). Water or foam may cause frothing. However, a water spray or fog that is gently applied to the surface of the liquid, preferably with a fire spray or fog nozzle, will cause frothing that will blanket and extinguish fire.
Water spray or mist can be used to absorb heat, keep containers cool and protect exposed material. If a leak or spill has not ignited, use water spray to disperse the vapours, dilute the spill to a nonflammable mixture and protect personnel attempting to stop a leak. Water spray may be used to flush spills away from ignition sources.
TPGEE is practically nonhazardous to health. Firefighters may enter the area if positive pressure self-contained breathing apparatus (MSHA/NIOSH approved or equivalent) and full Bunker Gear is worn.


NFPA - Comments:
NFPA has no listing for this chemical in Codes 49 or 325.


Molecular Weight: 220.3

Conversion Factor:
1 ppm = 8.99 mg/m3; 1 mg/m3 = 0.11 ppm at 25 deg C (calculated)

Physical State: Liquid
Melting Point: Not available
Boiling Point: 252 deg C (486 deg F) at 760 mm Hg (2)
Relative Density (Specific Gravity): 0.948 at 25 deg C (water = 1) (2)
Solubility in Water: Probably soluble in all proportions.
Solubility in Other Liquids: Soluble in a variety of organic solvents (characteristic of the chemical family)
Coefficient of Oil/Water Distribution (Partition Coefficient): Not available
pH Value: Not available
Viscosity-Kinematic: 5.45 centistokes at 25 deg C (2)
Vapour Density: 7.58 (air = 1)
Vapour Pressure: 0.0015 kPa (0.011 mm Hg) at 25 deg C (1); also reported as 0.0027 kPa (0.02 mmHg) at 25 deg C (2)
Saturation Vapour Concentration: 0.00145% (14.5 ppm) at 25 deg C; 0.0026% (126 ppm) at 25 deg C (calculated)
Evaporation Rate: Not available


Normally stable

Hazardous Polymerization:
Will not occur.

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.

OXIDIZING AGENTS - contact with TPGEE may increase the risk of fire and explosion.

STRONG ACIDS - may cause decomposition of ethers.

Hazardous Decomposition Products:
None reported

Conditions to Avoid:
Temperatures above 132 deg C

Corrosivity to Metals:
Not corrosive

Stability and Reactivity Comments:
Some glycol ethers can form peroxides during prolonged storage in contact with air. Formation of peroxides occurs more readily in sunlight. The rate and extent of peroxide formation with TPGEE is unknown, but is expected to be low. This is not expected to pose any hazard.


LD50 (oral, rat): 1.90 g/kg (reported as 2 mL/kg) (1)

EYE IRRITATION (rabbit): Repeated applications (5 days) produced slight irritation with no corneal injury.(1)

SKIN IRRITATION (rabbit): Repeated application resulted in slight irritation, without evidence that toxic amounts were absorbed.(1)

Note: Animal toxicity data is based on unpublished data presented in reference 1.


Selected Bibliography:
(1) Patty's industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. John Wiley & Sons, 1982. p. 3975, 3996-3997
(2) Industrial solvents handbook. 3rd ed. E.W. Flick, ed. Noyes Data Corporation, 1985. p. 430
(3) Langhorst, M. Glycol ethers--validation procedures for tube/pump and dosimeter monitoring methods. Am. Ind. Hyg. Assoc. J. Vol. 45, no. 6 (1984). p. 416-424

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.

Review/Preparation Date: 1993-03-03

Revision Indicators:
TDG 1994-03-01
Fire fighting instructions 1995-01-01
Conditions to avoid 1995-01-01
TLV comments 1995-11-01
EU class 1995-11-01
US transport 1995-11-01
Respiratory guidelines 1995-11-01
Sampling 1996-01-01
Resistance of materials 1998-05-01
Bibliography 1998-05-01
WHMIS disclosure list 2003-05-30
Carcinogenicity 2003-05-30
PEL-TWA transitional 2003-10-16

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