INTOX Home Page
DIAZOMETHANE ICSC: 1256
Date of Peer Review: March 1995

Azimethylene
Diazirine
CAS # 334-88-3 CH2N2
RTECS # PA7000000 Molecular mass: 42.04
UN #
EC # 006-068-00-8
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Extremely flammable. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking.
Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out; in other cases extinguish with powder, carbon dioxide.
EXPLOSION Gas/air mixtures are explosive.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT expose to friction or shock. Prevent build-up of electrostatic charges (e.g., by grounding).
Combat fire from a sheltered position.
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Headache. Laboured breathing. Shortness of breath. Sore throat. Vomiting. Malaise. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Skin Redness. Burning sensation. Pain. Serious frostbite.
Cold-insulating gloves.
ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention. Wear protective gloves when administering first aid.
Eyes Redness. Pain.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion
Do not eat, drink, or smoke during work.

SPILLAGE DISPOSAL PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Ventilation. Personal protection: complete protective clothing including self-contained breathing apparatus.
EU Classification
Symbol: T
R: 45
S: 53-45
UN Classification

EMERGENCY RESPONSE STORAGE

Solutions of diazomethane should not be stored (see Notes).
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 1999

SEE IMPORTANT INFORMATION ON BACK
DIAZOMETHANE ICSC: 1256
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
YELLOW GAS.

PHYSICAL DANGERS:
The gas is heavier than air and may travel along the ground; distant ignition possible.

CHEMICAL DANGERS:
May explosively decompose on shock, friction, or concussion. May explode on heating at 100C, or on contact with rough surfaces or if impurities or solids are present in the undiluted liquid or in the concentrated solutions, or under high intensity lighting. Contact with alkali metals and calcium sulfate causes explosions.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.2 ppm as TWA; (ACGIH 2004).
MAK: Carcinogen category: 2; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation.

INHALATION RISK:
A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is very corrosive to the eyes, the skin and the respiratory tract. Inhalation of the vapour may cause lung oedema (see Notes). Inhalation of the vapour may cause asthmatic reactions (see Notes). The liquid may cause frostbite. Exposure above the OEL may result in death. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged inhalation exposure may cause asthma. This substance is possibly carcinogenic to humans.
PHYSICAL PROPERTIES
Boiling point: -23C
Melting point: -145C
Relative density (water = 1): 1.45
Solubility in water: reaction
Relative vapour density (air = 1): 1.4
Flash point: Flammable Gas
Auto-ignition temperature: (explosion) 100C
ENVIRONMENTAL DATA

NOTES
Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. The relation between odour and the occupational exposure limit cannot be indicated. The recommendations on this Card also apply to concentrated solutions of diazomethane.
Card has been partly updated in April 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 1999