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CHLORPYRIFOS ICSC: 0851
Date of Peer Review: October 2005

O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothioate
O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioic acid ester
Chlorpyrifos-ethyl
CAS # 2921-88-2 C9H11Cl3NO3PS
RTECS # TF6300000 Molecular mass: 350.6
UN # 2783
EC Index # 015-084-00-4
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray, foam, powder, carbon dioxide.
EXPLOSION


EXPOSURE
STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Pupillary constriction, muscle cramp, excessive salivation. Sweating. Dizziness. Nausea. Vomiting. Diarrhoea. Muscle twitching. Convulsions. Unconsciousness.
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin MAY BE ABSORBED! (See Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Blurred vision.
Face shield or eye protection in combination with breathing protection if powder.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion (See Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give a slurry of activated charcoal in water to drink. Refer for medical attention immediately.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place.
Do not transport with food and feedstuffs. Severe marine pollutant.
EU Classification
Symbol: T, N
R: 25-50/53
S: (1/2-)-45-60-61
UN Classification
UN Hazard Class: 6.1
UN Pack Group: III
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61GT7-III
Store in an area without drain or sewer access. Keep in a well-ventilated room. Separated from strong bases, strong acids, food and feedstuffs.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
CHLORPYRIFOS ICSC: 0851
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS TO WHITE CRYSTALS, WITH CHARACTERISTIC ODOUR.

CHEMICAL DANGERS:
The substance decomposes on heating at approximately 160C producing toxic and corrosive fumes including hydrogen chloride, phosgene, phosphorus oxides, nitrogen oxides, sulfur oxides. Reacts with strong bases, acids.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: (Inhalable vapour and aerosol) 0.1 mg/m as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2005).
MAK not established.
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin, and by ingestion.

INHALATION RISK:
A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the nervous system, resulting in convulsions and respiratory depression. Cholinesterase inhibition. Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.
PHYSICAL PROPERTIES
Decomposes below boiling point at 160C
Melting point: 41-42C
Density: 1.4 g/cm
Solubility in water: 1.4 mg/l (very poor)
Vapour pressure, Pa at 25C: 0.0024
Octanol/water partition coefficient as log Pow: 4.7-5.27
ENVIRONMENTAL DATA
The substance is very toxic to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to birds and honey bees. Bioaccumulation of this chemical may occur along the food chain, for example in fish and algae. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.
NOTES
If the pesticide is present in a formulation containing hydrocarbon solvents, vomiting should not be induced. Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. If the substance is formulated with solvents also consult the ICSCs of these materials. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005