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THEOPHYLLINE ICSC: 0678
Date of Peer Review: September 1993

3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
1,3-Dimethylxanthine
CAS # 58-55-9 C7H8N4O2
RTECS # XH3850000 Molecular mass: 180.2
UN #
EC Index #
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

In case of fire in the surroundings: use appropriate extinguishing media.
EXPLOSION


EXPOSURE
AVOID EXPOSURE OF (PREGNANT) WOMEN!
IN ALL CASES CONSULT A DOCTOR!
Inhalation See Ingestion.
Avoid inhalation of fine dust and mist.
Fresh air, rest. Refer for medical attention.
Skin
Protective gloves.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
Eyes
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Convulsions. Headache. Nausea. Vomiting. Irritability. Insomnia.
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Then remove to safe place. Personal protection: P2 filter respirator for harmful particles.
Do not transport with food and feedstuffs.
EU Classification
UN Classification

EMERGENCY RESPONSE STORAGE

Separated from food and feedstuffs.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
THEOPHYLLINE ICSC: 0678
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS, WHITE CRYSTALLINE POWDER.

CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes including nitrogen oxides.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

INHALATION RISK:
No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the cardiovascular system, central nervous system liver.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Animal tests show that this substance possibly causes toxicity to human reproduction or development.
PHYSICAL PROPERTIES
Melting point: 270-274C
Solubility in water: moderate
Octanol/water partition coefficient as log Pow: -0.02 (estimated)
ENVIRONMENTAL DATA

NOTES
Accurbrom, Bilordyl, Bronchorectard, Elixicon, Lasma, Sabidal, Theochram, Xanthium are trade names.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005