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TETRAHYDROFURAN ICSC: 0578
Date of Peer Review: October 1997

Tetramethylene oxide
Diethylene oxide
1,4-Epoxybutane
Oxacyclopentane
CAS # 109-99-9 C4H8O / (CH2)3CH2O
RTECS # LU5950000 Molecular mass: 72.1
UN # 2056
EC Index # 603-025-00-0
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Highly flammable.
NO open flames, NO sparks, and NO smoking.
Powder, alcohol-resistant foam, water in large amounts, carbon dioxide.
EXPLOSION Vapour/air mixtures are explosive.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT GENERATION OF MISTS!

Inhalation Cough. Dizziness. Headache. Nausea. Sore throat. Unconsciousness.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
Skin Dry skin. Redness. Pain.
Protective gloves.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
Eyes Redness. Pain.
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion (See Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: filter respirator for organic gases and vapours.
Airtight.
EU Classification
Symbol: F, Xi
R: 11-19-36/37
S: (2-)-16-29-33
UN Classification
UN Hazard Class: 3
UN Pack Group: II
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-30S2056 or 30GF1-I+II
NFPA Code: H2; F3; R1;
Fireproof. See Chemical Dangers. Store only if stabilized.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
TETRAHYDROFURAN ICSC: 0578
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID, WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The vapour is heavier than air and may travel along the ground; distant ignition possible.

CHEMICAL DANGERS:
The substance can form explosive peroxides. Reacts violently with strong oxidants, strong bases and some metal halides, causing fire and explosion hazard. Attacks some forms of plastic rubber and coatings.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 50 ppm as TWA, 100 ppm as STEL; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2005).
MAK: 50 ppm, 150 mg/m; Peak limitation category: I(2); skin absorption (H); Carcinogen category: 4; Pregnancy risk group: C; (DFG 2005).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance or the vapour is irritating to the eyes, the skin and the respiratory tract. The substance may cause effects on the central nervous system at high level, resulting in narcosis.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis.
PHYSICAL PROPERTIES
Boiling point: 66C
Melting point: -108.5C
Relative density (water = 1): 0.89
Solubility in water: miscible
Vapour pressure, kPa at 20C: 19.3
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20C (air = 1): 1.28
Flash point: -14.5C c.c.
Auto-ignition temperature: 321C
Explosive limits, vol% in air: 2-11.8
ENVIRONMENTAL DATA

NOTES
p-Cresol or hydroquinone are commonly used stabilizers. Use of alcoholic beverages enhances the harmful effect. An added stabilizer or inhibitor can influence the toxicological properties of this substance, consult an expert. The odour warning when the exposure limit value is exceeded is insufficient. Check for peroxides prior to distillation; eliminate if found. Card has been partly updated in October 2005. See sections Occupational Exposure Limits, Emergency Response.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005