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PROPIONIC ANHYDRIDE ICSC: 0558
Date of Peer Review: October 2005

Propanoic anhydride
Methylacetic anhydride
Propanoic acid anhydride
CAS # 123-62-6 C6H10O3 / (CH3CH2CO)2O
RTECS # UF9100000 Molecular mass: 130.2
UN # 2496
EC Index # 607-010-00-X
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 63C explosive vapour/air mixtures may be formed.
Above 63C use a closed system, ventilation.

EXPOSURE
PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!

Inhalation Sore throat. Cough. Burning sensation. Shortness of breath. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin Pain. Skin burns.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
Eyes Redness. Pain. Severe deep burns.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Burning sensation. Abdominal pain. Shock or collapse. Sore throat.
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Personal protection: chemical protection suit. Use face shield. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place.
Do not transport with food and feedstuffs.
EU Classification
Symbol: C
R: 34
S: (1/2-)-26-45
UN Classification
UN Hazard Class: 8
UN Pack Group: III
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-80GC3-II+III
NFPA Code: H2; F2; R1;
Dry. Ventilation along the floor. Separated from bases, oxidants, food and feedstuffs.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
PROPIONIC ANHYDRIDE ICSC: 0558
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID, WITH PUNGENT ODOUR.

PHYSICAL DANGERS:
The vapour is heavier than air.

CHEMICAL DANGERS:
The substance decomposes on contact with water producing corrosive propionic acid. Reacts violently with bases and oxidants causing fire and explosion hazard.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established. MAK not established.
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and by ingestion.

INHALATION RISK:
No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the eyes, the skin and the respiratory tract. Inhalation of vapour or aerosol may cause lung oedema (see Notes). Corrosive on ingestion. The effects may be delayed. Medical observation is indicated.

PHYSICAL PROPERTIES
Boiling point: 167C
Melting point: -45C
Relative density (water = 1): 1.01
Solubility in water: reaction
Vapour pressure, kPa at 20C: 0.1
Relative vapour density (air = 1): 4.5
Relative density of the vapour/air-mixture at 20C (air = 1): 4.4
Flash point: 63C c.c.
Auto-ignition temperature: 285C
Explosive limits, vol% in air: 1.3-9.5
ENVIRONMENTAL DATA

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005