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ISOPHORONE DIISOCYANATE ICSC: 0499
Date of Peer Review: March 1999

3-Isocyanatomethyl - 3,5,5-trimethylcyclohexyl isocyanate
Isocyanic acid, methylene (3,5,5-trimethyl-3, 1-cyclohexylene)ester
IPDI
CAS # 4098-71-9 C12H18N2O2 / (CH3)2C6H7(CH3)(N=C=O)CH2N=C=O
RTECS # NQ9370000 Molecular mass: 222,3
UN # 2290
EC Index # 615-008-00-5
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION


EXPOSURE
PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Cough. Laboured breathing. Sore throat. Wheezing. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Skin Redness.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
Eyes Redness. Pain.
Safety goggles, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Burning sensation. Sore throat.
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Rest. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Treat remaining liquid with dilute ammonia solution. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Personal protection: chemical protection suit including self-contained breathing apparatus.
Airtight. Do not transport with food and feedstuffs.
EU Classification
Symbol: T, N
R: 23-36/37/38-42/43-51/53
S: (1/2-)-26-28-38-45-61
Note: [2]
UN Classification
UN Hazard Class: 6.1
UN Pack Group: III
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61S2290
NFPA Code: H2; F1; R1; W
Separated from bases, acids, alcohols, amines, amides, phenols, mercaptans, food and feedstuffs. See Chemical Dangers. Cool. Dry.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

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ISOPHORONE DIISOCYANATE ICSC: 0499
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS TO YELLOW LIQUID, WITH PUNGENT ODOUR.

CHEMICAL DANGERS:
The substance may polymerize due to warming and under the influence of strong bases and metal compounds. May explode on heating. The substance decomposes on burning producing toxic fumes including nitrogen oxides, hydrogen cyanide, carbon monoxide, carbon dioxide. Reacts slowly with water at room temperature, vigorously at high temperature; violently with alcohols, acids, bases, amines, amides, phenols, mercaptanes. Attacks plastic and rubber.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.005 ppm as TWA; (ACGIH 2004).
MAK: 0.005 ppm, 0.046 mg/m; Peak limitation category: I(1); sensitization of respiratory tract and skin (Sah); Pregnancy risk group: IIc; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly especially on spraying and heating.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance and the aerosol is irritating to the eyes the skin and the respiratory tract. Inhalation of aerosol may cause lung oedema (see Notes). Inhalation of aerosols may cause asthmatic reactions (see Notes). The substance may cause effects on the skin, resulting in sensitization.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma.
PHYSICAL PROPERTIES
Boiling point at 13.3kPa: 217C
Melting point: -60C
Relative density (water = 1): 1.1
Solubility in water: reaction
Vapour pressure, Pa at 20C: 0.04
Relative density of the vapour/air-mixture at 20C (air = 1): 1.0
Flash point: 155C c.c.
Auto-ignition temperature: 430C
Explosive limits, vol% in air: 0.7-4.5
ENVIRONMENTAL DATA
The substance is toxic to aquatic organisms.
NOTES
Temperature of decomposition unknown in literature. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation is therefore essential. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. The symptoms of acute intoxications may not become manifest until several hours. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home.
Card has been partly updated in October 2004. See sections Occupational Exposure Limits, EU classification, Emergency Response.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005