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DIMETHYL SULPHOXIDE ICSC: 0459
Date of Peer Review: October 2000

Methyl sulphoxide
DMSO
CAS # 67-68-5 C2H6OS / (CH3)2SO
RTECS # PV6210000 Molecular mass: 78.1
UN #
EC Index #
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray, foam, powder, carbon dioxide.
EXPLOSION Above 87C explosive vapour/air mixtures may be formed.
Above 87C use a closed system, ventilation, and explosion-proof electrical equipment.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT GENERATION OF MISTS! STRICT HYGIENE!

Inhalation Headache. Nausea.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest.
Skin MAY BE ABSORBED! Dry skin.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Redness. Blurred vision.
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Nausea. Vomiting. Drowsiness.
Do not eat, drink, or smoke during work.
Do NOT induce vomiting. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Special attention to avoid skin absorption. Personal protection: filter respirator for organic gases and vapours.
EU Classification
UN Classification

EMERGENCY RESPONSE STORAGE
NFPA Code: H1; F1; R0;
Separated from strong oxidants. Cool. Keep in the dark. Keep in a well-ventilated room.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
DIMETHYL SULPHOXIDE ICSC: 0459
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS, HYGROSCOPIC LIQUID

PHYSICAL DANGERS:
The vapour is heavier than air and may travel along the ground; distant ignition possible.

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including sulfur oxides. Reacts violently with strong oxidants such as perchlorates.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
MAK: IIb (not established but data is available); skin absorption (H); (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes and the skin. Exposure to high concentrations of the substance could cause lowering of consciousness. May accelerate skin absorption of other materials (see Notes).

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver and blood, resulting in impaired functions and lesions of blood cells.
PHYSICAL PROPERTIES
Boiling point: 189C
Melting point: 18.5C
Relative density (water = 1): 1.1
Solubility in water: miscible
Vapour pressure, Pa at 20C: 59.4
Relative vapour density (air = 1): 2.7
Flash point: 87C c.c.
Auto-ignition temperature: 215C
Explosive limits, vol% in air: 2.6-42.0
Octanol/water partition coefficient as log Pow: -1.35 (calculated)
ENVIRONMENTAL DATA

NOTES
Special attention needed when toxic materials present in Dimethyl sulphoxide because of enhanced skin absorption. Card has been partly updated in October 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005