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N,N-DIMETHYLFORMAMIDE ICSC: 0457
Date of Peer Review: October 2000

Dimethylformamide
DMF
DMFA
N-Formyldimethylamine
CAS # 68-12-2 C3H7NO / HCON(CH3)2
RTECS # LQ2100000 Molecular mass: 73.09
UN # 2265
EC Index # 616-001-00-X
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking. NO contact with oxidants.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 58C explosive vapour/air mixtures may be formed.
Above 58C use a closed system, ventilation.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT GENERATION OF MISTS! AVOID EXPOSURE OF (PREGNANT) WOMEN!

Inhalation Abdominal pain. Diarrhoea. Nausea. Vomiting. Facial flushing.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
Skin MAY BE ABSORBED!
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Redness. Pain.
Safety goggles or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion
Do not eat, drink, or smoke during work.
Rinse mouth.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.
EU Classification
Symbol: T
R: 61-20/21-36
S: 53-45
Note: [E]
UN Classification
UN Hazard Class: 3
UN Pack Group: III
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-30S2265 or 30GF1-III
NFPA Code: H1; F2; R0;
Separated from strong oxidants, halogens.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
N,N-DIMETHYLFORMAMIDE ICSC: 0457
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS TO YELLOW LIQUID, WITH CHARACTERISTIC ODOUR.

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including nitrogen oxides. Reacts violently with oxidants, nitrates and halogenated hydrocarbons. Attacks some plastic and rubber.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 10 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2004).
MAK: 5 ppm, 15 mg/m; Peak limitation category: II(4); skin absorption (H); Pregnancy risk group: B; (DFG 2005).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin.

INHALATION RISK:
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes. The substance may cause effects on the liver, resulting in jaundice. See Notes.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the liver, resulting in impaired functions. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
PHYSICAL PROPERTIES
Boiling point: 153C
Melting point: -61C
Relative density (water = 1): 0.95
Solubility in water: miscible
Vapour pressure, Pa at 25C: about 492
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20C (air = 1): 1.00
Flash point: 58C c.c.
Auto-ignition temperature: 445C
Explosive limits, vol% in air: 2.2-15.2 at 100C
Octanol/water partition coefficient as log Pow: -0.87
ENVIRONMENTAL DATA

NOTES
Use of alcoholic beverages enhances the harmful effect. Resulting symptoms could be delayed from several hours up to several days. Environmental effects from the substance have been investigated but none have been found. Card has been partly updated in October 2005. See sections Occupational Exposure Limits, Emergency Response.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005