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CAFFEINE ICSC: 0405
Date of Peer Review: March 1998

1,3,7-Trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Methyltheobromine
Methyltheophylline
CAS # 58-08-2 C8H10N4O2
RTECS # EV6475000 Molecular mass: 194.19
UN # 1544
EC Index # 613-086-00-5
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray, powder.
EXPLOSION


EXPOSURE
PREVENT DISPERSION OF DUST!

Inhalation (See Ingestion).
Local exhaust or breathing protection.
Fresh air, rest. Refer for medical attention.
Skin
Protective gloves.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Headache. Dizziness. Abdominal cramps. Nausea. Vomiting. Convulsions. Tremors.
Do not eat, drink, or smoke during work.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: P2 filter respirator for harmful particles.
Do not transport with food and feedstuffs.
EU Classification
Symbol: Xn
R: 22
S: (2-)
UN Classification
UN Hazard Class: 6.1

EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61GT2-III
Separated from food and feedstuffs. Well closed.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
CAFFEINE ICSC: 0405
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
ODOURLESS WHITE CRYSTALS OR CRYSTALLINE POWDER.

CHEMICAL DANGERS:
The substance decomposes on burning producing toxic fumes including nitrogen oxides.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on dust forming.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the central nervous system and cardiovascular system, resulting in insomnia, excitement, tachycardia, polyuria.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Animal tests show that this substance possibly causes toxic effects upon human reproduction.
PHYSICAL PROPERTIES
Sublimation point: 178C
Melting point: 238C
Density: 1.23 g/cm
Solubility in water, g/100 ml: 2.17
Octanol/water partition coefficient as log Pow: -0.07
ENVIRONMENTAL DATA

NOTES
Card has been partly updated in October 2005. See section Emergency Response.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005