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ARSENIC PENTOXIDE ICSC: 0377
Date of Peer Review: March 1998

Arsenic (V) oxide
Arsenic acid anhydride
Arsenic anhydride
CAS # 1303-28-2 As2O5
RTECS # CG2275000 Molecular mass: 229.8
UN # 1559
EC Index # 033-004-00-6
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

In case of fire in the surroundings: use appropriate extinguishing media.
EXPLOSION


EXPOSURE
PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Cough. Sore throat. Headache. Dizziness. Weakness. Shortness of breath. Pain in chest. Symptoms may be delayed (see Notes), (see Ingestion).
Local exhaust or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer for medical attention.
Skin Redness. Burning sensation. Pain.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Redness. Pain.
Safety goggles or eye protection in combination with breathing protection if powder.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Vomiting. Abdominal pain. Diarrhoea. Severe thirst, muscular cramps, shock. (See Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Do NOT wash away into sewer. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Remove airborne particles with fine water spray. Do NOT let this chemical enter the environment. Personal protection: chemical protection suit including self-contained breathing apparatus.
Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. Marine pollutant.
EU Classification
Symbol: T, N
R: 45-23/25-50/53
S: 53-45-60-61
Note: [E]
UN Classification
UN Hazard Class: 6.1
UN Pack Group: II
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61GT5-II
NFPA Code: H2; F0; R0
Separated from strong bases, reducing substances, food and feedstuffs. Dry. Well closed.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
ARSENIC PENTOXIDE ICSC: 0377
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
WHITE HYGROSCOPIC POWDER.

CHEMICAL DANGERS:
The substance decomposes on heating above 300C producing toxic fumes (arsenic trioxide - see ICSC 0378) and oxygen. The solution in water is a weak acid. Reacts violently with bromine pentafluoride causing fire and explosion hazard. Reacts with reducing agents, producing very toxic gas (arsine - ICSC 0222). Attacks many metals in presence of water or moisture.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: (as As) 0.01 mg/m as TWA; A1 (confirmed human carcinogen); BEI issued; (ACGIH 2004).
MAK: Carcinogen category: 1; Germ cell mutagen group: 3A; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes, the skin and the respiratory tract. The substance may cause effects on the blood, cardiovascular system, peripheral nervous system and liver. Exposure far above the OEL may result in death. The effects may be delayed (see Notes). Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the skin (hyperkeratosis), cardiovascular system, peripheral nervous system, bone marrow (hematopoietic changes), liver, and lungs. This substance is carcinogenic to humans.
PHYSICAL PROPERTIES
Melting point (decomposes): 315C
Density: 4.3 g/cm
Solubility in water, g/100 ml at 20C: 65.8
ENVIRONMENTAL DATA
This substance may be hazardous to the environment; special attention should be given to fauna and water organisms.
NOTES
Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of acute poisoning do not become manifest until some hours. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. No odour warning if toxic concentrations are present. Do NOT take working clothes home. The recommendations on this Card also apply to inorganic pentavalent arsenic compounds (arsenates). Card has been partly updated in October 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005