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para-TOLUIDINE ICSC: 0343
Date of Peer Review: March 1995

4-Amino-1-methylbenzene
4-Aminotoluene
p-Methylaniline
CAS # 106-49-0 C7H9N / C6H4CH3NH2
RTECS # XU3150000 Molecular mass: 107.2
UN # 1708
EC Index # 612-160-00-4
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames. NO contact with nitric acid.
Powder, AFFF, foam, carbon dioxide.
EXPLOSION Above 86C explosive vapour/air mixtures may be formed.
Above 86C use a closed system, ventilation.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Blue lips or finger nails. Blue skin. Confusion. Dizziness. Headache. Laboured breathing. Nausea. Shortness of breath. Unconsciousness. Weakness.
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin MAY BE ABSORBED! Redness. Blue lips or fingernails. Blue skin. (Further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Redness. Pain. Severe deep burns.
Safety goggles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Blue lips or fingernails. Blue skin. Dizziness. Headache. Laboured breathing. (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Sweep spilled substance into sealable containers. Carefully collect remainder, then remove to safe place. Personal protection: complete protective clothing including self-contained breathing apparatus.
Do not transport with food and feedstuffs.
EU Classification
Symbol: T, N
R: 23/24/25-36-40-43-50
S: (1/2-)-28-36/37-45-61
UN Classification
UN Hazard Class: 6.1
UN Pack Group: II
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61GT2-II
NFPA Code: H3; F2; R0
Separated from strong oxidants, strong acids, food and feedstuffs. Cool. Dry. Well closed. Ventilation along the floor.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
para-TOLUIDINE ICSC: 0343
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS FLAKES TURNS DARK ON EXPOSURE TO AIR AND LIGHT.

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including nitrogen oxides. Reacts violently with oxidants, especially nitric acid.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 2 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued; (ACGIH 2004).
MAK: skin absorption (H); sensitization of skin (Sh); Carcinogen category: 3B; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes and the skin. The substance may cause effects on the blood, bladder and kidneys, resulting in tissue lesions and formation of methaemoglobin. Exposure to high concentrations may result in damage to kidneys and bladder. The effects may be delayed. Medical observation is indicated. See Notes.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood, resulting in formation of methaemoglobin (see Notes).
PHYSICAL PROPERTIES
Boiling point: 200C
Melting point: 44-45C
Relative density (water = 1): 1.05
Solubility in water: poor
Vapour pressure, kPa at 42C: 0.13
Relative vapour density (air = 1): 3.9
Flash point: 86-87C c.c.
Auto-ignition temperature: 482C
Explosive limits, vol% in air: 1.1-6.6
Octanol/water partition coefficient as log Pow: 1.39
ENVIRONMENTAL DATA

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home. Also consult ICSC # 0341 ortho-Toluidine and 0342 meta-Toluidine. Card has been partly updated in October 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005