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METHYLENE BISPHENYL ISOCYANATE ICSC: 0298
Date of Peer Review: March 1999

Diphenylmethane-4.4'-diisocyanate
bis(1,4-Isocyanatophenyl)methane
MDI
4,4'-Methylenediphenyldiisocyanate
CAS # 101-68-8 C15H10N2O2 / OCNC6H4CH2C6H4NCO
RTECS # NQ9350000 Molecular mass: 250.3
UN #
EC Index # 615-005-00-9
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, carbon dioxide.
EXPLOSION


EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Headache. Nausea. Shortness of breath. Sore throat.
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin Redness.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
Eyes Pain.
Safety goggles or face shield.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Sweep spilled substance into sealable containers. Carefully collect remainder, then remove to safe place. Chemical protection suit including self-contained breathing apparatus.
Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.
EU Classification
Symbol: Xn
R: 20-36/37/38-42/43
S: (1/2-)-23-36/37-45
Note: [C]
UN Classification

EMERGENCY RESPONSE STORAGE

Separated from food and feedstuffs, incompatible materials. See Chemical Dangers. Cool. Dry. Keep in the dark.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
METHYLENE BISPHENYL ISOCYANATE ICSC: 0298
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
WHITE TO PALE YELLOW CRYSTALS OR FLAKES.

CHEMICAL DANGERS:
The substance may polymerize under the influence of temperatures above 204C. On combustion, forms toxic and corrosive fumes including nitrogen oxides and hydrogen cyanide (see ICSC 0492). Reacts readily with water to form insoluble polyureas. Reacts violently with acids, alcohols, amines, bases and oxidants causing fire and explosion hazard.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.005 ppm as TWA; (skin); (ACGIH 2004).
MAK: (Inhalable fraction) 0.05 mg/m; Peak limitation category: I(1); sensitization of respiratory tract and skin (Sah); Carcinogen category: 3B; Pregnancy risk group: IIc; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

EFFECTS OF SHORT-TERM EXPOSURE:
Tear drawing. The substance irritates the eyes, the skin and the respiratory tract. The substance may cause effects on the lungs, resulting in impaired functions.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma (see Notes).
PHYSICAL PROPERTIES
Boiling point at 100 kPa: 314C
Melting point: 37C
Relative density (water = 1): 1.2
Solubility in water: reaction
Vapour pressure, Pa at 20C: negligible
Relative vapour density (air = 1): 8.6
Flash point: 196C c.c.
Auto-ignition temperature: 240C
ENVIRONMENTAL DATA

NOTES
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. MDI may sensitize workers so that they react to other isocyanates (asthma). Do NOT take working clothes home. Caradate 30, Desmodur 44, Hylene M 150, Isonate, Nacconate 300, NCI-C50668, Rubinate 44 are trade names. Card has been partly updated in October 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005