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HEXAMETHYLPHOSPHORIC TRIAMIDE ICSC: 0162
Date of Peer Review: October 1994

Hexamethylphosphoramide
Hexamethylphosphamide
HMPA
CAS # 680-31-9 C6H18N3OP / {(CH3)2N}3P(O)
RTECS # TD0875000 Molecular mass: 179.2
UN #
EC # 015-106-00-2
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION


EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
Inhalation
Ventilation, local exhaust, or breathing protection.
Refer for medical attention.
Skin MAY BE ABSORBED!
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes
Safety spectacles or face shield.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion
Do not eat, drink, or smoke during work.
Rinse mouth. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: self-contained breathing apparatus.
EU Classification
Symbol: T
R: 45-46
S: 53-45
UN Classification

EMERGENCY RESPONSE SAFE STORAGE

Ventilation along the floor.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2004

SEE IMPORTANT INFORMATION ON BACK


HEXAMETHYLPHOSPHORIC TRIAMIDE ICSC: 0162
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS MOBILE LIQUID.

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including phosphorus oxides nitrogen oxides.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004).
MAK: skin absorption (H); Carcinogen category: 2; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin.

INHALATION RISK:
No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the lungs, kidneys and central nervous system, resulting in impaired functions and depression.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the respiratory tract, kidneys and bone marrow. This substance is possibly carcinogenic to humans. May cause genetic damage in humans.
PHYSICAL PROPERTIES
Boiling point: 232C
Melting point: 5-7C
Relative density (water = 1): 1.03
Solubility in water: very good
Vapour pressure, Pa at 20C: 4
Relative vapour density (air = 1): 6.18
Relative density of the vapour/air-mixture at 20C (air = 1): 1.00
Flash point: 105C
ENVIRONMENTAL DATA

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Hexametapol is a trade name.
Card has been partly updated in April 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2004