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DIMETHYL SULFATE ICSC: 0148
Date of Peer Review: March 1995

Sulfuric acid dimethyl ester
Dimethyl monosulfate
DMS
CAS # 77-78-1 C2H6O4S / (CH3O)2SO2
RTECS # WS8225000 Molecular mass: 126.13
UN # 1595
EC Index # 016-023-00-4
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray, foam, powder, carbon dioxide.
EXPLOSION Above 83C explosive vapour/air mixtures may be formed.
Above 83C use a closed system, ventilation.

EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Burning sensation. Cough. Headache. Shortness of breath. Sore throat. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Skin MAY BE ABSORBED! Skin burns. Pain. Blisters.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Redness. Pain. Blurred vision. Severe deep burns.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Abdominal cramps. Burning sensation. Convulsions. Diarrhoea. Shock or collapse. Vomiting. (Further see Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give plenty of water to drink. Refer for medical attention immediately.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. Personal protection: complete protective clothing including self-contained breathing apparatus.
Airtight. Special material. Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.
EU Classification
Symbol: T+
R: 45-25-26-34-43-68
S: 53-45
Note: [E]
UN Classification
UN Hazard Class: 6.1
UN Subsidiary Risks: 8
UN Pack Group: I
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61S1595 or 61GTC1-I
NFPA Code: H4; F2; R0;
Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Ventilation along the floor.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
DIMETHYL SULFATE ICSC: 0148
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS, OILY LIQUID.

PHYSICAL DANGERS:
The vapour is heavier than air.

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including sulfur oxides. The solution in water is a medium strong acid. Reacts with water to produce sulfuric acid with evolution of heat. Reacts violently with concentrated aqueous ammonia, bases, acids and strong oxidants with risk of fire and explosion.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.1 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004).
MAK: skin absorption (H); Carcinogen category: 2; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the eyes, the skin, the respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema (see Notes). Ingestion of the substance may cause oedema of lips, tongue and pharynx. The substance may cause effects on the liver, kidneys and central nervous system, resulting in impaired functions. Exposure above the OEL may result in death. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Lungs may be affected by repeated or prolonged exposure to the vapour. This substance is probably carcinogenic to humans.
PHYSICAL PROPERTIES
Boiling point (decomposes): 188C
Melting point: -32C
Relative density (water = 1): 1.33
Solubility in water: hydrolysis above 18C
Vapour pressure, Pa at 20C: 65
Relative vapour density (air = 1): 4.35
Flash point: 83C
Auto-ignition temperature: 470C
Explosive limits, vol% in air: 3.6-23.3
ENVIRONMENTAL DATA
The substance is toxic to aquatic organisms.
NOTES
The onset of symptoms can occur after a relatively asymptomatic latent period of 6-24 hours. Commercial dimethyl sulfate may contain trace amounts of sulfuric acid. Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. No odour warning if toxic concentrations are present. Do NOT take working clothes home. NEVER pour water into this substance; when dissolving or diluting always add it slowly to the water. Card has been partly updated in October 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005