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SECTION 1. CHEMICAL IDENTIFICATION

CHEMINFO Record Number: 724
CCOHS Chemical Name: Phthalic anhydride solid

Synonyms:
1,2-Benzenedicarboxylic acid anhydride
1,2-Benzenedicarboxylic anhydride
1,3-Dihydro-1,3-dioxoisobenzofuran
1,3-Dioxophthalan
1,3-Isobenzofurandione
PAN
1,3-Phthalandion
1,3-Phthalandione
Phthalic anhydride (non-specific name)
Phthalic acid anhydride
Anhydride phtalique solide

Chemical Name French: Anhydride phtalique (solide)
Chemical Name Spanish: Anhídrido ftálico
CAS Registry Number: 85-44-9
UN/NA Number(s): 2214
RTECS Number(s): TI3150000
EU EINECS/ELINCS Number: 201-607-5
Chemical Family: Aromatic carboxylic acid anhydride / aromatic dicarboxylic acid anhydride / benzenedicarboxylic acid anhydride / phthalic acid isomer
Molecular Formula: C8-H4-O3
Structural Formula: -C(=O)-C6H4-C(=O)-O-

SECTION 2. DESCRIPTION

Appearance and Odour:
Colourless, white or pale yellow solid flakes, crystals or powder with a choking, acrid odour.(20)

Odour Threshold:
No reliable values are available. A minimum perceptible value of 0.053 ppm has been reported.(21)

Warning Properties:
NOT RELIABLE - no reliable odour threshold values have been reported.

Composition/Purity:
Commercial phthalic anhydride generally has a purity of 99% or more. It may contain small amounts of maleic anhydride (up to 1%), phthalic acid, benzoic acid and traces of naphthoquinone as impurities.(5,6,20,22) It is stored, shipped and used as a solid or in molten liquid form. This CHEMINFO record is for solid phthalic anhydride. Refer to CHEMINFO 723 for information on the molten liquid.

Uses and Occurrences:
Phthalic anhydride is used mainly in the production of plasticizers (e.g. di(2-ethylhexyl)phthalate), unsaturated polyesters and alkyd resins. Smaller uses include the manufacture of other chemicals like anthraquinone, phthalimide, phenolphthalein, isatoic anhydride and halogenated phthalic anhydrides, used as fire retardants; dyes and pigments; resin hardeners; and pharmaceutical intermediates.(5,20,22,23)


SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW:
Colourless, white or pale yellow solid flakes, crystals or powder with a choking, acrid odour. Can burn if strongly heated. COMBUSTIBLE DUST. Can form explosive dust-air mixtures. Irritating to the respiratory tract. Causes eye irritation. RESPIRATORY SENSITIZER. May cause severe allergic respiratory reaction. SKIN SENSITIZER. May cause severe allergic skin reaction.



POTENTIAL HEALTH EFFECTS

Effects of Short-Term (Acute) Exposure

Inhalation:
Exposure to airborne dust can cause irritation of the nose, throat and upper respiratory tract, based on animal and human information. The severity of symptoms depends on the airborne concentration and the duration of exposure. Runny nose, coughing, and nose bleeds, may occur based on human information.(1) Phthalic anhydride does not readily form a vapour at room temperature.
Irritation of the nose and respiratory tract (bronchitis) were reported by 40% and 17%, respectively, of workers exposed to dust during loading of chemical reactors with flaked phthalic anhydride. The workers were exposed to 6.1 to 6.8 mg/m3 phthalic anhydride dust for 5 to 30 minutes, once or twice per shift. By comparison, irritation of the nose was reported by only 5/25 workers who did not load reactors (exposure level unknown).(2) Symptoms of nose irritation were reported in 28/118 present or former polyester resin production workers. The exposure level for these workers was not reported.(3) No irritation was experienced in 27 volunteers exposed to airborne concentration ranging from 0.22 to 0.75 mg/m3.(1) However, it is not possible to evaluate this study because full details are unavailable.
Some individuals can develop an allergic sensitivity to phthalic anhydride. Refer to "Effects of Long-term (Chronic) Exposure" below for information.

Skin Contact:
Pure phthalic anhydride is expected to produce only mild irritation, based on animal information. It reacts with moisture to form phthalic acid which is not considered irritating. Commercial phthalic anhydride may contain small amounts of maleic anhydride as an impurity (up to 1%). Maleic anhydride absorbs moisture forming corrosive maleic acid. Therefore, depending upon the concentration of maleic anhydride and the amount of moisture present, phthalic anhydride may produce moderate to severe irritation or perhaps even corrosive skin injury.(4,5)
One report indicates that, during the production of commercial phthalic anhydride, contact with the crude material (containing 0.5% maleic anhydride) caused slight skin burns to employees.(4)

Eye Contact:
Pure phthalic anhydride is a moderate to severe eye irritant, based on animal information. Commercial phthalic anhydride may contain small amounts of maleic anhydride as an impurity (up to 1%). Maleic anhydride absorbs moisture forming corrosive maleic acid. Therefore, depending upon the concentration of maleic anhydride and the amount of moisture present, phthalic anhydride can produce moderate to severe irritation or perhaps even corrosive eye injury.(5,6)
Eight cases of corneal burns have been reported following occupational exposures. The eyes healed within 48 hours in all cases, following medical treatment.(7) Irritation of the inner eyelids and nose was reported by 17% of workers exposed to dust during loading of chemical reactors with flaked phthalic anhydride. The workers were exposed to 6.1 to 6.8 mg/m3 phthalic anhydride dust for 5 to 30 minutes, once or twice per shift.

Ingestion:
Depending on the concentration of maleic anhydride present, phthalic anhydride can cause mild to severe irritation to the mouth, throat and stomach. There is no human information available. Animal toxicity values indicate that oral toxicity is low. Ingestion is not a typical route of occupational exposure.

Effects of Long-Term (Chronic) Exposure

Respiratory Sensitization:
Exposure to phthalic anhydride can cause allergic respiratory sensitization, based on human and animal evidence. The results of chemical factory surveys in several countries provide convincing evidence that phthalic anhydride can cause asthma and rhinitis (nose irritation) in a proportion of exposed people.(38)
Sensitized people can experience symptoms of bronchial asthma such as wheezing, difficult breathing, sneezing and runny or blocked nose at low airborne concentrations that have no effect on unsensitized people. Symptoms can develop immediately following exposure or hours later.
Respiratory sensitization to phthalic anhydride was confirmed by a bronchial challenge test in a person exposed to phthalic anhydride dust in his job. This individual had no previous history of asthma, but was a smoker.(8)
Phthalic anhydride-induced asthma was diagnosed in 12% (6/48) of current employees and 21% (15/70) of former employees in factories producing polyester resins. Only 4 of the 21 asthmatics had a previous history of allergies. A high percentage (15/21) were smokers. In one sensitized individual, exposure to 0.5 mg/m3 phthalic anhydride for 10 minutes was enough to produce a response. It is not known whether the presence of maleic anhydride, trimellitic anhydride or toluene diisocyanate in these same factories influenced the development of asthma.(3) Other researchers have also studied respiratory sensitization presumably in this same group of employees.(1)
No conclusions can be drawn from another case report of asthma, because it is not clear that phthalic anhydride caused the sensitization reaction and the person had a history of allergies. A known sensitizer was likely present (diglycidyl ether of bisphenol A (Araldite)) and air monitoring to confirm the presence of phthalic anhydride was not conducted.(9)

Skin Sensitization:
Repeated or prolonged skin contact may cause an allergic skin reaction in some individuals, based on animal evidence and limited human information. Once a person is sensitized to a material, contact with even a small amount causes outbreaks of dermatitis with symptoms such as skin redness, itching, rash and swelling. This can spread from the hands or arms to other parts of the body.

A few cases of skin sensitization reactions to phthalic anhydride have been reported in the international literature, however, details are not available in English. One reviewer has concluded that since so few cases have been reported, it is likely that only a very small proportion of exposed persons are affected.(1) Phthalic anhydride is a skin sensitizer in animals.

Carcinogenicity:

There is no human information available. Carcinogenic effects were not observed in rats or mice in one ingestion study.

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has designated this chemical as not classifiable as a human carcinogen (A4).

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
There is no human or animal information available.

Reproductive Toxicity:
There is no human information available. No conclusions can be drawn from one limited study in rats.

Mutagenicity:
There is no information on effects in humans or from studies conducted with live animals. Mainly negative results have been obtained in tests using cultured mammalian cells. There is one unconfirmed report of a positive result (DNA damage) in cultured mammalian cells. Negative results have been obtained in bacteria tests.

Toxicologically Synergistic Materials:
There is no information available.

Potential for Accumulation:
Phthalic anhydride does not accumulate in the body. It is slowly converted to phthalic acid on contact with water and biological fluids. It has been shown that workers occupationally exposed to phthalic anhydride by inhalation, absorbed the substance with some being excreted in the urine as unconjugated phthalic acid. The half-life of phthalic anhydride/phthalic acid was shown to be about 14 hours. Urinary concentrations of the acid are related to exposure to the anhydride.(1,5)


SECTION 4. FIRST AID MEASURES

Inhalation:
Take proper precautions to ensure your own safety before attempting rescue; e.g. wear appropriate protective equipment. Remove source of contamination or have victim move to fresh air. Obtain medical attention immediately.

Skin Contact:
Avoid direct contact with this chemical. Wear chemical resistant protective gloves, if necessary. Quickly and gently brush away excess chemical. Flush contaminated area with lukewarm, gently flowing water for at least 5 minutes, or until the chemical is removed. Under running water, remove contaminated clothing, shoes, and leather goods (e.g. watchbands, belts). If irritation persists, repeat flushing. Obtain medical attention immediately. Completely decontaminate clothing, shoes and leather goods before re-use, or discard.

Eye Contact:
Avoid direct contact. Wear chemical resistant gloves, if necessary. Quickly and gently brush away excess chemical. Immediately flush the contaminated eye(s) with lukewarm, gently flowing water for 20 minutes, or until the chemical is removed, while holding the eyelid(s) open. Take care not to rinse contaminated water into the non-affected eye or onto the face. Obtain medical attention immediately.

Ingestion:
NEVER give anything by mouth if victim is rapidly losing consciousness, or is unconscious or convulsing. DO NOT INDUCE VOMITING. Have victim drink 240 to 300 mL (8 to 10 oz) of water to dilute material in the stomach. If vomiting occurs naturally, rinse mouth and repeat administration of water. Obtain medical attention immediately.

First Aid Comments:
Provide general supportive measures (comfort, warmth, rest).
Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.
All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.



SECTION 5. FIRE FIGHTING MEASURES

Flash Point:
152 deg C (305 deg F) (closed cup) (24)

Lower Flammable (Explosive) Limit (LFL/LEL):
1.7% (20,22,26)

Upper Flammable (Explosive) Limit (UFL/UEL):
10.5% (20,22,26)

Autoignition (Ignition) Temperature:
570 deg C (1058 deg F) (20,28); 584 deg C (1083 deg F) (20,22)

Sensitivity to Mechanical Impact:
Probably not sensitive. Stable material.

Combustion and Thermal Decomposition Products:
Phthalic acid fumes and other toxic materials.(28) Incomplete combustion may also produce acrid smoke and irritating fumes.

Flammable Properties:

Specific Hazards Arising from the Chemical:
During a fire, irritating/toxic gases and fumes may be generated. Flammable and potentially explosive hydrogen gas may be generated if phthalic acid, formed by the reaction of water and phthalic anhydride, contacts and corrodes iron or mild steel.

Extinguishing Media:
Carbon dioxide, dry chemical powder, alcohol foam, polymer foam , water spray or fog.(20,28)

Fire Fighting Instructions:
Evacuate area and fight fire from a safe distance or a protected location. Approach fire from upwind to avoid toxic decomposition products.
Water or foam may cause frothing. The frothing may be violent and could endanger personnel close to the fire. However, a water spray or fog that is carefully applied to the surface of the burning material, preferably with a fine spray or fog nozzle, will cause frothing that will blanket and extinguish the fire. In addition, water spray or fog can be used to prevent dust formation and protect exposed material.
Closed containers may rupture violently when exposed to heat of fire. If possible, isolate materials not yet involved in the fire, and move containers from fire area if this can be done without risk, and protect personnel. Otherwise, fire-exposed containers or tanks should be cooled by application of hose streams. Application should begin as soon as possible and should concentrate on any unwetted portions of the container. Apply water from the side and from a safe distance until well after the fire is out. DO NOT get water into phthalic anhydride containers. If it is not possible to cool the containers, use unmanned monitor nozzles and immediately evacuate the area.
Water spray may be used to flush spills away from ignition sources. Solid streams of water may be ineffective and spread material. For a massive fire in a large area, use unmanned hose holder or monitor nozzles. If this is not possible, withdraw from fire area and allow fire to burn. Stay away from ends of tanks, but be aware that flying material from ruptured tanks may travel in any direction. Withdraw immediately in case of rising sound from venting safety device or any discolouration of tank due to fire.
Phthalic anhydride and its decomposition products may be hazardous to health. Do not enter without wearing specialized protective equipment suitable for the situation. Firefighter's normal protective equipment (Bunker Gear) will not provide adequate protection. Chemical resistant clothing (e.g. chemical splash suit) and positive pressure self-contained breathing apparatus (MSHA/NIOSH approved or equivalent) may be necessary.



NATIONAL FIRE PROTECTION ASSOCIATION (NFPA) HAZARD IDENTIFICATION

NFPA - Health: 2 - Intense or continued (but not chronic) exposure could cause temporary incapacitation or possible residual injury.
NFPA - Flammability: 1 - Must be preheated before ignition can occur.
NFPA - Instability: 0 - Normally stable, even under fire conditions, and not reactive with water.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Molecular Weight: 148.11

Conversion Factor:
1 ppm = 6.0 mg/m3; 1 mg/m3 = 0.17 ppm at 25 deg C (calculated)

Physical State: Solid
Melting Point: 131 deg C (268 deg F) (20,29)
Boiling Point: 284.5 deg C (544 deg F) (sublimes) (22,31); 295 deg C (563 deg F) (sublimes) (30)
Relative Density (Specific Gravity): 1.527 at 4 deg C (water=1) (5,6,22)
Solubility in Water: Slightly soluble (620-640 mg/100 g) at 20 deg C (slowly hydrolyses) (20,31)
Solubility in Other Liquids: Very soluble in acetone, tetrahydrofuran and pyridine; moderately soluble in ethyl acetate, methyl ethyl ketone and formic acid; slightly soluble in ethanol (reacts slowly), diethyl ether, benzene, carbon disulfide, carbon tetrachloride, cyclohexane and xylene.(1,6,22)
Coefficient of Oil/Water Distribution (Partition Coefficient): Not applicable (reacts)
pH Value: Not applicable. Reacts with water to form acidic solutions.
Vapour Density: 5.10 (air=1) (28)
Vapour Pressure: 2.66 x 10(-5) kPa (2.0 x 10(-4) mm Hg) at 20 deg C (31)
Saturation Vapour Concentration: 0.26 ppm at 20 deg C (calculated)
Evaporation Rate: Not available
Critical Temperature: 537 deg C (999 deg F) (29)

Other Physical Properties:
CRITICAL PRESSURE: 4762.7 kPa (47 atm.) (29)
TRIPLE POINT: 131 deg C (268 deg F) (22)


SECTION 10. STABILITY AND REACTIVITY

Stability:
Normally stable. Reacts slowly with water and water vapour at normal temperatures to form phthalic acid and heat.(20)

Hazardous Polymerization:
Does not occur.

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.


STRONG OXIDIZING AGENTS (e.g. perchlorates, peroxides, permanganates, sodium hypochlorite) - can react rapidly and violently with a the risk of fire and/or explosion.(20,28)
STRONG MINERAL OR ORGANIC ACIDS (e.g. hydrochloric acid, hydrofluoric acid, sulfuric acid, chlorosulfonic acid) - reaction can be sufficiently rapid and violent to cause an explosion.(20,28)
STRONG ALKALIS or CAUSTICS (e.g. sodium or potassium hydroxide) or BASES (e.g. ethylene diamine) - may react violently with spattering, accompanied by a temperature and pressure rise.(20,28)
WATER - reacts slowly with cold water, rapidly with hot water, producing phthalic acid and heat. Hot water may cause frothing. (20,32)
WATER and METALS (e.g. iron) - may form pyrophoric phthalic acid salts. Reaction of these iron salts with naphthoquinones (impurities in phthalic anhydride) form unstable materials, which can explode.(33)
STRONG REDUCING AGENTS (e.g. phosphorus, tin (II) chloride, metal hydrides) - may react vigorously or violently. Increased risk of fire.(28)
COPPER(II)OXIDE or SODIUM NITRITE - may explode violently on heating.(20,33)
NITRIC ACID and SULFURIC ACID - addition of fuming nitric acid to phthalic anhydride dissolved in sulfuric acid at 80-100 deg C may result in the formation of potentially explosive substances.(20,24,33)

Hazardous Decomposition Products:
Phthalic acid

Conditions to Avoid:
Static charge, sparks, heat, other ignition sources, generation of dust and moisture.

Corrosivity to Metals:
Dry phthalic anhydride (with or without maleic anhydride contamination) is not corrosive to cast iron, steel, stainless steel, nickel and its alloys and aluminum.(20,34) In the presence of water, phthalic anhydride is corrosive to ordinary iron and mild steel, because phthalic acid, and possibly small amounts of maleic acid, are formed.(20) Organic acids are generally not corrosive to types 304 and 316 stainless steels, and aluminum is generally resistant to organic acids at room temperature.(35)

Stability and Reactivity Comments:
Phthalic anhydride may attack some forms of plastics, rubber and coatings.(20)


SECTION 11. TOXICOLOGICAL INFORMATION

LC50 (male rat): greater than 52.5 mg/m3 (4- hour exposure); cited as greater than 0.21 mg/L (1-hour exposure) (dust) (0/6 died) (10)

LD50 (oral, rat): approximately 2000 mg/kg (unconfirmed) (1)
LD50 (oral, male rat): 4020 mg/kg (10)
LD50 (oral, mouse): 1500 mg/kg (unconfirmed) (11)

LD50 (dermal, rabbit): greater than 10000 mg/kg (0/6 died) (10)

Eye Irritation:

Phthalic anhydride is a moderate to severe eye irritant.

Application of 100 mg phthalic anhydride as a dry powder produced severe irritation in rabbits (graded 81/110) in one test.(10) Severe irritation (59.2/110) was also observed in rabbits in another test.(12) Application of a 5% solution of phthalic anhydride in polyethylene glycol 400 was reversibly irritating and 0.5% phthalic anhydride was non-irritating in rabbits.(13, unconfirmed) None of the studies specified the purity of the phthalic anhydride tested which complicates interpretation of the results.

Skin Irritation:

Phthalic anhydride causes no to mild skin irritation.

Application of 500 mg as a dry powder, moistened with water or a salt solution, produced mild irritation in rabbits (graded 1/8 and 1.5/8) in two tests.(10,12) In another test, application of 500 mg phthalic anhydride for 1 hour or 4 hours did not produce irritation in rabbits.(13, unconfirmed) Application of a 50% phthalic anhydride solution in oil for 20 hours was not irritating to the ears of rabbits.(13, unconfirmed) Application of a 10% phthalic anhydride solution in oil for an unspecified time was slightly irritating to rabbits.(13, unconfirmed) None of the studies specified the purity of the phthalic anhydride tested which complicates interpretation of the results.

Effects of Short-Term (Acute) Exposure:

Inhalation:
Severe irritant effects on the lung (bleeding, increased cell growth and acute and chronic inflammation) have been observed in rats following inhalation of phthalic anhydride. Animals were exposed to approximately 0.5 mg/m3 for 5 days, followed by a 3-week rest period and a further 6-hour exposure to the same concentration.(1, unconfirmed)

Ingestion:
No treatment-related effects on survival, food consumption, organ/body weight ratios or terminal body weight were observed in rats fed 12.5 to 190 mg/kg/day (estimated doses) for 4 weeks.(10)

Effects of Long-Term (Chronic) Exposure:

Inhalation:
Inflammation of the mucous membranes of the respiratory tract, often with secondary pneumonia, was observed in guinea pigs following intermittent inhalation exposure to 8.5 mg/m3 phthalic anhydride over 8 months.(13, unconfirmed) Details regarding reversibility of the observed effects are not available.

Ingestion:
No harmful effects, except for weight reduction at high doses, were observed in rats fed approximately 375-750 mg/kg/day or mice fed approximately 2450-4900 mg/kg/day for about 2 years.(14) Similarly, no treatment-related effects, except reduction in body weight gain at the highest dose, were observed in rats fed approximately 310-2500 mg/kg/day or mice fed approximately 930-7500 mg/kg/day for 13 weeks.(14) No conclusions can be drawn from one other poorly reported study.(15)

Skin Sensitization:
Phthalic anhydride has produced skin sensitization in animals. Sensitization was produced in 90% of the animals tested in a guinea pig maximization test. Phthalic anhydride was described as an extreme sensitizer. The number of animals used in the test was not reported. Positive results were also obtained in another test using mice (local lymph node assay).(16) In another study, skin sensitization was also observed in 5/6 guinea pigs following application of phthalic anhydride.(17)

Respiratory Sensitization:
Evidence of sensitization (immediate respiratory symptoms at challenge and specific antibody production) was observed in guinea pigs exposed to phthalic anhydride at concentrations as low as 0.5 mg/m3 over 5 days. Challenge testing was conducted with an aerosolized phthalic anhydride- protein conjugate (phthalic anhydride-guinea pig serum albumin conjugate).(18)

Carcinogenicity:
No carcinogenic effects were observed in mice and rats fed phthalic anhydride at high doses (375-750 mg/kg/day for rats and approximately 2450-4900 mg/kg/day for mice) for 104 and 105 weeks.(14)

Reproductive Toxicity:
No conclusions can be drawn from the one available study due to insufficient information. A dose-related decrease in sperm mobility and changes in semen content were observed in rats exposed by inhalation to 0.2 or 1 mg/m3 phthalic anhydride for 45 days prior to mating. These effects were not observed at 0.02 mg/m3.(13, unconfirmed)


SECTION 16. OTHER INFORMATION

Selected Bibliography:
(1) Ridgway, P., et al., Health and Safety Executive. Acid anhydrides: criteria document for an occupational exposure limit. HSE Books, 1996
(2) Nielsen, J., et al. Specific serum antibodies against phthalic anhydride in occupationally exposed subjects. Journal of Allergy and Clinical Immunology. Vol. 82, no. 1 (July 1988). p. 126-133
(3) Wernfors, M., et al. Phthalic anhydride-induced occupational asthma. International Archives of Allergy and Applied Immunology. Vol. 79, no. 1 (Jan. 1986). p. 77-82
(4) Merlevede, E. et al. Intoxication due to phthalic anhydride, maleic anhydride and phthalates. Archives Belges de Medecine Sociale, Hygiene, Medecine du Travail et Medecine Legale. Vol. 5 (1957). p. 445-457. (HSE Translation no. 11485)
(5) Keskinen, H. Organic acid anhydrides. In: Criteria documents from the Nordic Expert Group 1990. Edited by B. Beije, et al. Arbete och Halsa. No. 2 (1991). p. 129-188
(6) Towae, F.K., et al. Phthalic acid and derivatives. In: Ullmann's encyclopedia of industrial chemistry. 5th completely revised ed. Vol. A 20. VCH Verlagsgesellschaft, 1992. p. 181-190, 198-199
(7) McLaughlin, R.S. Chemical burns of the human cornea. American Journal of Ophthalmology. Vol. 29, no. 11 (Nov. 1946). p. 1355-1362
(8) Maccia, C.A., et al. In vitro demonstration of specific IgE in phthalic anhydride hypersensitivity. American Review of Respiratory Disease. Vol. 113, no. 5 (May 1976). p. 701-704
(9) Ward, M.J. et al. Asthma due to grinding epoxy resin cured with phthalic anhydride. Clinical Allergy. Vol. 12 (1982). p. 165-168
(10) Anonymous. Phthalic anhydride. (Data sheet No. 13-4/70). Industrial-Test Laboratories, Inc., Northbrook, Illinois, 1970
(11) Izmerov, N.F., et al. Toxicometric parameters of industrial toxic chemicals under single exposure. United Nations Environmental Programme (UNEP). Centre of International Projects, GKNT, 1982
(12) Gad, S.C., et al. Correlation of ocular and dermal irritancy of industrial chemicals. Journal of Toxicology-Cutaneous and Ocular Toxicology. Vol. 5, no. 3 (Sept. 1986). p. 195-213
(13) Dutch expert committee for occupational standards. Health-based recommended occupational exposure limit for phthalic anhydride. Directorate- General of Labour, the Netherlands, June 1989
(14) Kluwe, W.M., et al. Carcinogenicity testing of phthalate esters and related compounds by the National Toxicology Program and the National Cancer Institute. Environmental Health Perspectives. Vol. 45 (Nov. 1982). p. 129-133
(15) Pludro, G., et al. Toxicological and chemical studies of some epoxy resins and hardeners: I. Determination of acute and subacute toxicity of phthalic acid anhydride, 4,4'-diaminodiphenylmethane and of the epoxy resin: Epilox EG-34. Acta Poloniae Pharmaceutica. Vol. 26, no. 4 (1969). p. 352-357
(16) Basketter, D.A., et al. Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food and Chemical Toxicology. Vol. 30, no. 1 (Jan. 1992). p. 65-69
(17) Duyeva, L.A., et al. Experimental assessment of the sensitizing and irritating action of phthalate plasticizers. Gigiena Truda i Professional'nye Zabolevaniya. Vol. 13, no. 10 (1969). p. 17-19. (English translation: NIOSHTIC Control Number: 00033611)
(18) Sarlo, K., et al. Induction of type I hypersensitivity in guinea pigs after inhalation of phthalic anhydride. Journal of Allergy and Clinical Immunology. Vol. 94, no. 4 (Oct. 1994). p. 747-756
(19) RTECS record for phthalic anhydride. Last updated: 1997-04
(20) Emergency action guide for phthalic anhydride. Association of American Railroads, Oct. 1993
(21) Odor thresholds for chemicals with established occupational health standards. American Industrial Hygiene Association, 1989. p. 27, 73
(22) Park, C-H, et al. Phthalic acids and other benzenepolycarboxylic acids. In: Kirk-Othmer encyclopedia of chemical technology. 4th ed. Vol. 18. John Wiley and Sons, 1996. p. 991-1006
(23) HSDB record for phthalic anhydride. Last revision date: 97/05/01
(24) Fire protection guide to hazardous materials. 13th ed. Edited by A.B. Spencer, et al. National Fire Protection Association, 2002. NFPA 325; NFPA 49
(25) Schwab, R.F. Dusts. In: Fire protection handbook. Edited by A.E Cote. 18th ed. National Fire Protection Association, 1997. p. 4-174 to 4-181
(26) Grossel, S.S. Safety considerations in conveying of bulk solids and powders. Journal of Loss Prevention in the Process Industries. Vol. 1 (Apr. 1988). p. 62-74
(27) Field, P. Dust explosions. Elsevier Scientific Publishing Company, 1982. p. 214
(28) The Sigma-Aldrich library of chemical safety data. Ed. II. Vol. 2. Sigma-Aldrich Corporation, 1988
(29) Dean, J.A. Lange's handbook of chemistry. 14th ed. McGraw-Hill, Inc., 1992. p. 1.171, 6.144
(30) Weast, R.C., ed. Handbook of chemistry and physics. 66th ed. CRC Press, 1985-1986
(31) Verschueren, K. Handbook of environmental data on organic chemicals. 3rd ed. Van Nostrand Reinhold, 1996
(32) NIOSH pocket guide to chemical hazards. National Institute for Occupational Safety and Health, June 1997
(33) Urben, P.G., ed. Bretherick's handbook of reactive chemical hazards. 5th ed. Vol. 1. Butterworth-Heinemann Ltd., 1995. p. 935-936
(34) Corrosion data survey: metals section. 6th ed. National Association of Corrosion Engineers, 1985. p. 98-1 to 99-1, 98-2 to 99-2
(35) Elder, G.B. Materials of construction for organic acids. In: Process industries corrosion: the theory and practice. Edited by B.J. Moniz, et al. National Association of Corrosion Engineers, 1986. p. 287-296
(36) Forsberg, K., et al. Quick selection guide to chemical protective clothing. 4th ed. Van Nostrand Reinhold, 2002
(37) European Communities. Commission Directive 98/73/EC. Sept. 18, 1998
(38) Health and Safety Executive (HSE). Asthmagen? Critical assessments of the evidence for agents implicated in occupational asthma. HSE Books, 1997 with amendments 1998, 2001

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.


Review/Preparation Date: 1998-06-22

Revision Indicators:
TLV-TWA 2000-06-01
TLV comments 2000-06-01
EU Risk 1999-12-01
EU Safety 1999-12-01
EU Comments 1999-12-01
TDG 2002-05-29
NFPA (health) 2003-04-18
PEL transitional comments 2003-12-19
PEL-TWA final 2003-12-19
TLV basis 2004-01-04
Resistance of materials for PPE 2004-04-06
EU classification 2005-02-06
Bibliography 2006-05-18
Long-term exposure 2006-05-18



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