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PHOSPHAMIDON ICSC: 0189
Date of Peer Review: October 2005

2-Chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate
2-Chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl phosphate
Dimethyl phosphate ester 2-chloro-N,N-diethyl-3-hydroxycrotonamide
O,O-Dimethyl-O-(2-chloro-2-diethylcarbamoyl-1-methylvinyl) phosphate
CAS # 13171-21-6 C10H19ClNO5P
RTECS # TC2800000 Molecular mass: 299.7
UN # 3018
EC Index # 015-022-00-6
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.

In case of fire in the surroundings: use appropriate extinguishing agent
EXPLOSION


EXPOSURE
STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Sweating. Muscle twitching. Pupillary constriction, muscle cramp, excessive salivation. Diarrhoea. Dizziness. Laboured breathing. Vomiting. Convulsions. Unconsciousness. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin MAY BE ABSORBED! (Further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Redness. Pain.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Abdominal cramps. (Further see Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give a slurry of activated charcoal in water to drink. Refer for medical attention immediately. See Notes.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable non-metallic containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.
Do not transport with food and feedstuffs. Severe marine pollutant.
EU Classification
Symbol: T+, N
R: 24-28-68-50/53
S: (1/2-)-23-36/37-45-60-61
UN Classification
UN Hazard Class: 6.1
UN Pack Group: II
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61GT6-II
Store in an area without drain or sewer access. Well closed. Keep in a well-ventilated room. Separated from bases, food and feedstuffs.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK
PHOSPHAMIDON ICSC: 0189
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS TO YELLOW OILY LIQUID

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing highly toxic fumes including phosphorus oxides hydrogen chloride and nitrogen oxides. Reacts with bases (hydrolysis). Attacks metals such as iron, tin and aluminium.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: BEI issued; (ACGIH 2005).
MAK not established.
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes. The substance may cause effects on the nervous system, resulting in convulsions, respiratory depression and death. Exposure at high levels may result in death. Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.
PHYSICAL PROPERTIES
Boiling point at 0.2 kPa: 162C
Melting point: -45C
Relative density (water = 1): 1.2
Solubility in water: miscible
Vapour pressure, Pa at 20C: 0.0033
Octanol/water partition coefficient as log Pow: 0.8
ENVIRONMENTAL DATA
The substance is very toxic to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to birds and honey bees. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.
NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Commercial product is a mixture of isomers. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home. Pillarcron, Dimecron and Phosron are trade names.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2005
See Also:
        Phosphamidon (PDS)
        Phosphamidon (PIM 454)