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SECTION 1. CHEMICAL IDENTIFICATION

CHEMINFO Record Number: 634
CCOHS Chemical Name: Methylene iodide

Synonyms:
Diiodomethane
Iodure de méthylène
Methylene diiodide

CAS Registry Number: 75-11-6
RTECS Number(s): PA8575000
EU EINECS/ELINCS Number: 200-841-5
Chemical Family: Halogenated aliphatic hydrocarbon / saturated halogenated hydrocarbon / halogenated alkane / haloalkane / dihaloalkane / iodoalkane / diiodoalkane
Molecular Formula: C-H2-I2
Structural Formula: I-CH2-I

SECTION 2. DESCRIPTION

Appearance and Odour:
Colourless liquid which darkens (yellow/brown) upon exposure to light, air and moisture.

Odour Threshold:
No information available

Warning Properties:
Insufficient information for evaluation.

Composition/Purity:
Commercial preparations contain silver wool or copper for stability.

Uses and Occurrences:
Used in the separation of mixtures of minerals, the manufacture of x-ray contrast media, the determination of the specific gravity of minerals and other substances and organic synthesis.


SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW:
Colourless liquid which darkens upon exposure to light. Can decompose at high temperatures forming toxic gases. Causes skin and eye irritation. May be a central nervous system depressant. Vapour may cause headache, nausea, dizziness, drowsiness, reduced coordination and confusion. Very high concentrations may cause unconsciousness and death.



POTENTIAL HEALTH EFFECTS

Effects of Short-Term (Acute) Exposure

Inhalation:
Methylene iodide can probably cause slight nose and throat irritation. Low concentrations may cause mild central nervous system depression, characterized by light-headedness, dizziness, nausea, numbness in hands and feet, fatigue, inability to concentrate, and reduced coordination. Very high levels may cause loss of consciousness and death. These conclusions are based on human information for the related chemicals, methylene chloride and methyl iodide, as well as animal information for the related chemicals, iodoform and methylene bromide.

Skin Contact:
The liquid is probably slightly irritating. If trapped against the skin, it may cause more severe irritation. There may be slight absorption through the skin. The effects of absorption may be similar to those central nervous system effects described for inhalation. These conclusions are based on limited descriptive information (1,4), as well as human information available for the related chemical, methyl iodide, and animal information for the related chemical, methylene bromide.

Eye Contact:
The liquid or concentrated vapours can probably cause slight irritation. The liquid may cause temporary corneal damage. These conclusions are based on limited descriptive information (1,4) as well as human information available for the related chemicals, methylene chloride and methyl iodide, and animal information for the related chemicals, iodoform and methylene bromide.

Ingestion:
Methylene iodide may be moderately toxic if ingested and cause symptoms of central nervous system depression similar to those described for inhalation. This conclusion is based on animal data available for other dihalomethanes (methylene chloride and methylene bromide) as well as other iodide compounds (iodoform).

Effects of Long-Term (Chronic) Exposure

There is no specific information available on the effects of long-term exposure to methylene iodide. However, repeated exposure may cause central nervous system (CNS) and liver injury. This conclusion is based on human information for the related chemical, methylene chloride. Animal information for other related chemicals, methylene bromide and iodoform, indicate that long-term high level exposure to methylene iodide may cause liver and kidney injury as well as CNS disorders. Animal studies indicate that methylene iodide is metabolized to carbon monoxide. For information on the effect of carbon monoxide in the heart, please see CHEMINFO 57E.

Carcinogenicity:

There is no specific information available for methylene iodide. The related chemicals methylene chloride and chloroform are classified as A2 carcinogens (suspected human carcinogens) by the ACGIH and 2B carcinogens (possible human carcinogens) by IARC. In addition, the related chemical methyl iodide is classified as an A2 carcinogen by the ACGIH.

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
No information available. Animal studies indicate that methylene iodide is metabolized to carbon monoxide. For information on the teratogenicity and embryotoxicity of carbon monoxide, please see CHEMINFO 57E.

Reproductive Toxicity:
No information available

Mutagenicity:
Positive results in short-term (bacterial) tests. No other information available.

Toxicologically Synergistic Materials:
No information available

Potential for Accumulation:
Animal studies indicate that methylene iodide is metabolized to carbon monoxide, formic acid and iodine.(8) Elevated blood levels of carboxyhemoglobin may result from carbon monoxide (see CHEMINFO 57E for the effects of carbon monoxide).


SECTION 4. FIRST AID MEASURES

Inhalation:
Take proper precautions to ensure your own safety before attempting rescue (e.g., wear appropriate protective equipment, use the buddy system). Remove source of contamination or move victim to fresh air. If breathing has stopped, trained personnel should begin artificial respiration or, if the heart has stopped, cardiopulmonary resuscitation (CPR) immediately. Avoid mouth-to-mouth contact by using mouth guards or shields. Immediately transport victim to an emergency care facility.

Skin Contact:
As quickly as possible, flush with lukewarm, gently flowing water for at least 20 minutes or until the chemical is removed. Under running water, remove contaminated clothing, shoes and leather goods (e.g. watchbands, belts). If breathing has stopped, trained personnel should begin artificial respiration (AR) or, if the heart has stopped, cardiopulmonary resuscitation (CPR) immediately. Avoid mouth-to-mouth contact by using mouth guards or shields. Obtain medical attention immediately. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
Immediately flush the contaminated eye(s) with lukewarm, gently flowing water for 20 minutes or until the chemical is removed, holding the eyelid(s) open. Take care not to rinse contaminated water into the non-affected eye or onto the face. Obtain medical attention immediately.

Ingestion:
Never give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. Have victim rinse mouth thoroughly with water. DO NOT INDUCE VOMITING. Have victim drink 240 to 300 mL (8 to 10 oz.) of water. If vomiting occurs naturally, rinse mouth and repeat administration of water. If breathing has stopped, trained personnel should begin artificial respiration or, if the heart has stopped, cardiopulmonary resuscitation (CPR) immediately. Avoid mouth-to-mouth contact by using mouth guards or shields. Quickly transport victim to an emergency care facility. Obtain medical attention immediately.

First Aid Comments:
Provide general supportive measures (comfort, warmth, rest).
Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.
All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.



SECTION 5. FIRE FIGHTING MEASURES

Flash Point:
Greater than 110 deg C (230 deg F) (4)

Lower Flammable (Explosive) Limit (LFL/LEL):
Not available

Upper Flammable (Explosive) Limit (UFL/UEL):
Not available

Autoignition (Ignition) Temperature:
Not available

Sensitivity to Mechanical Impact:
No information available, but probably stable under normal conditions.

Sensitivity to Static Charge:
No information available, but probably not sensitive under normal conditions.

Combustion and Thermal Decomposition Products:
Carbon monoxide, carbon dioxide and hydrogen iodide.

Fire Hazard Summary:
This material can burn if strongly heated.

Extinguishing Media:
Water spray, carbon dioxide, dry chemical powder, alcohol foam or polymer foam.

Fire Fighting Instructions:
Move containers from fire area if it can be done without risk. Use water spray to keep fire-exposed containers cool. Water spray may be used to flush spills away and prevent exposures.

Firefighters may enter the area if positive pressure self-contained breathing apparatus (MSHA/NIOSH approved or equivalent) and full Bunker Gear is worn.



NATIONAL FIRE PROTECTION ASSOCIATION (NFPA) HAZARD IDENTIFICATION

NFPA - Comments:
NFPA has no listing for this chemical in Codes 49 or 325.


SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Molecular Weight: 267.87

Conversion Factor:
1 ppm = 11 mg/m3; 1 mg/m3 = 0.09 ppm at 25 deg C (calc.)

Physical State: Liquid
Melting Point: 5 deg C (41 deg F)
Boiling Point: 180 deg C (356 deg F) (decomposes)
Relative Density (Specific Gravity): 3.325 (water = 1)
Solubility in Water: Moderately soluble (1.42 g/100 ml of water at 20 deg C)
Solubility in Other Liquids: Miscible with alcohol, propanol, isopropanol, hexane, cyclohexane, ether, chloroform and benzene.
Coefficient of Oil/Water Distribution (Partition Coefficient): Not available
pH Value: Not available
Vapour Density: 9.25 (air = 1) (9)
Vapour Pressure: 11 mm Hg at 68 deg C (10)
Saturation Vapour Concentration: 14476 mm Hg at 68 deg C (calc.)
Evaporation Rate: Not available
Critical Temperature: Not available

SECTION 10. STABILITY AND REACTIVITY

Stability:
Decomposes at 180 deg C (1). May darken (to yellow or brown) when exposed to light, air and moisture due to formation of iodine.(7)

Hazardous Polymerization:
Does not occur

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.


STRONG OXIDIZERS - may react vigorously.

STRONG BASES - may react vigorously.

ALKALI METAL SALTS - reacts violently.(4)

METALS (e.g. potassium, lithium) - mixtures are shock sensitive and may explode with great violence on light impact.(5)

Hazardous Decomposition Products:
No information available

Conditions to Avoid:
Temperatures above 180 deg C

Corrosivity to Metals:
No information available


SECTION 11. TOXICOLOGICAL INFORMATION

Standard animal toxicity values are not available for this chemical.


SECTION 16. OTHER INFORMATION

Selected Bibliography:
(1) Hawley's condensed chemical dictionary. 11th ed. Van Nostrand Reinhold, 1987. p. 768
(2) Kirk-Othmer encyclopedia of chemical technology. Vol. 13. 3rd ed. John Wiley & Sons, 1981. p. 668-670
(3) Blank
(4) The Sigma-Aldrich library of chemical safety data. Edition II. Vol. 1. Sigma-Aldrich, 1988. p. 1285C
(5) Bretherick, L. Bretherick's handbook of reactive chemical hazards. 4th ed. Butterworths, 1990. p. 143, 493, 1288-1289, 1314-1315
(6) RTECS record for methane, diiodo-. Date of last udpate 9201
(7) The Merck index: an encyclopedia of chemicals, drugs, and biologicals. 10th ed. Merck, 1983. p. 869
(8) Ahmed, A.E., et al. Halogenated methanes : metabolism and toxicity. Federation Proceedings. Vol. 39, no. 13 (Nov. 1980). p. 3150-3155
(9) Diiodomethane (J T Baker Chemical Co). Printout from TRADE NAMES data base, July 21 1990
(10) Personal communication. Aldrich Chemical Co. Inc. January, 1991
(11) NIOSH pocket guide to chemical hazards. NIOSH, June 1994. p. 210-211

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.


Review/Preparation Date: 1992-09-14

Revision Indicators:
Trans PEL-TWA 1993-04-01
TDG 1994-02-01
Fire fighting instructions 1994-09-01
HANDLING AND STORAGE 1994-09-01
Description 1994-12-01
Respiratory guidelines 1994-12-01
Conditions to avoid 1994-12-01
US Transport 1996-06-01
Sampling 1996-06-01
Resistance to materials 1996-06-01
EU class 1996-06-01
Bibliography 1996-06-01
Resistance of materials 1998-05-01
Bibliography 1998-05-01
Carcinogenicity 2003-06-16



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