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ISOPHORONE ICSC: 0169
Date of Peer Review: April 2000

1,1,3-Trimethyl-3-cyclohexene-5-one
3,5,5-Trimethylcyclohex-2-enone
Isoacetophorone
CAS # 78-59-1 C9H14O
RTECS # GW7700000 Molecular mass: 138.2
UN #
EC # 606-012-00-8
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Above 84C explosive vapour/air mixtures may be formed.
Above 84C use a closed system, ventilation.

EXPOSURE
PREVENT GENERATION OF MISTS!

Inhalation Burning sensation. Sore throat. Cough. Dizziness. Headache. Nausea. Shortness of breath.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin
Protective gloves.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Blurred vision.
Safety spectacles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Abdominal pain. (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Do NOT induce vomiting.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: filter respirator for organic gases and vapours.
EU Classification
Symbol: Xn
R: 21/22-36/37-40
S: (2-)-13-23-36/37/39-46
UN Classification

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H 2; F 2; R 0;
Separated from strong oxidants, strong bases, amines.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2004

SEE IMPORTANT INFORMATION ON BACK


ISOPHORONE ICSC: 0169
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID, WITH CHARACTERISTIC ODOUR.

CHEMICAL DANGERS:
Reacts with strong oxidants, strong bases and amines.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 5 ppm; (Ceiling value); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004).
MAK: 2 ppm, 11 mg/m; Peak limitation category: I(2); Carcinogen category: 3B; Pregnancy risk group: C; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance and the vapour of this substance is irritating to the eyes and the respiratory tract. The substance may cause effects on the central nervous system.

PHYSICAL PROPERTIES
Boiling point: 215C
Melting point: -8C
Relative density (water = 1): 0.92
Solubility in water, g/100 ml at 25C: 1.2
Vapour pressure, Pa at 20C: 40
Relative vapour density (air = 1): 4.8
Flash point: 84C c.c.
Auto-ignition temperature: 460C
Explosive limits, vol% in air: 0.8-3.8
Octanol/water partition coefficient as log Pow: 1.67
ENVIRONMENTAL DATA

NOTES
The occupational exposure limit value should not be exceeded during any part of the working exposure.
Card has been partly updated in April 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2004
See Also:
        Isophorone (CHEMINFO)
        Isophorone (EHC 174, 1995)