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CHEMINFO Record Number: 172
CCOHS Chemical Name: Dipropylene glycol monoethyl ether

1-(2-ethoxy-2 methylethoxy)-2-propanol
Dipropylene glycol ethyl ether
Ether monoethylique du dipropyleneglycol

CAS Registry Number: 15764-24-6
Chemical Family: Aliphatic ether alcohol / aliphatic glycol ether / aliphatic diglycol ether / aliphatic diglycol monoether / propylene glycol ether / dipropylene glycol monoether
Molecular Formula: C8-H18-O3
Structural Formula: CH3-CH(OH)-CH2-O-CH2-CH(CH3)-O-CH2CH3


Appearance and Odour:
Colourless liquid

Odour Threshold:
No information available

Warning Properties:
Insufficient information available for evaluation.

Uses and Occurrences:
Propylene glycol ethers have diverse solvent applications including paints, lacquers, resins, inks, dyes, oils/greases and cleaners. Propylene glycol ethers are frequently chosen as substitutes for the more toxic ethylene glycol ethers.


Colourless liquid. Little or no hazard if spilled. COMBUSTIBLE LIQUID AND VAPOUR. High vapour or mist concentrations may be irritating to respiratory tract.


Effects of Short-Term (Acute) Exposure

High concentrations of mist and vapour are expected to cause marked irritation of nose and throat, based on animal studies and characteristics of this chemical family.
Since vapour concentration cannot exceed about 400 ppm under normal conditions, depression of the central nervous system is not expected to occur unless dipropylene glycol monoethyl ether (DPGEE) is heated or a mist formed. (Concentrations in the range of 1000 ppm were required to produce nervous system depression for the chemically-related propylene glycol methyl ether.)

Skin Contact:
Based on animal data and characteristics of this chemical family, irritation from skin contact with DPGEE is not expected to occur. If DPGEE were confined against the skin by an impermeable covering (e.g. gloves) for an extended period of time, irritation or burns might occur as was found in animal studies.

DPGEE appears to be readily absorbed through the skin; however, toxic amounts could be absorbed only through extensive, prolonged contact, not from normal handling and use. Toxicity would be marked by headache, nausea, light-headedness, drowsiness, incoordination or possible unconsciousness, indicating depression of the central nervous system.

Eye Contact:
Based on animal tests, direct eye contact with DPGEE is expected to produce mild irritation, but no damage.
High vapour concentrations of another member of this chemical family, propylene glycol monomethyl ether, caused irritation and watering of the eyes. This is also expected for DPGEE.

The low acute oral toxicity of DPGEE in animal studies indicates that it is unlikely that toxic amounts would be ingested during normal handling and use. Although no cases of ingestion have been reported, the effect would be depression of the central nervous system.

Effects of Long-Term (Chronic) Exposure

There are no reported chronic exposure studies for animals or humans.


No human or animal information is available

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
No human or animal information is available

Reproductive Toxicity:
No human or animal information is available

No information is available

Toxicologically Synergistic Materials:
No information is available

Potential for Accumulation:
Based on what is known about dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether probably readily enters the body by inhalation, dermal and oral routes, but is unlikely to accumulate.

Health Comments:
The limited data available for this material indicates relatively low toxicity. Under normal conditions of use the hazards are expected to be minimal, however, it is best to minimize contact/exposure until more information is available.


If symptoms are experienced, remove source of contamination or move victim to fresh air. Obtain medical advice immediately.

Skin Contact:
As quickly as possible, flush with lukewarm, gently flowing water for at least 5 minutes or until the chemical is removed. Wash gently and thoroughly with water and non-abrasive soap. Under running water, remove contaminated clothing, shoes and leather goods (e.g. watchbands, belts). If irritation persists, repeat flushing. Obtain medical advice immediately. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
If irritation occurs, immediately flush the contaminated eye(s) with lukewarm, gently flowing water for at least 5 minutes, or until the chemical is removed, while holding the eyelid(s) open. If irritation persists, obtain medical advice immediately.

Never give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. DO NOT INDUCE VOMITING. Have victim drink 240 to 300 mL (8 to 10 oz.) of water. If vomiting occurs naturally, rinse mouth and repeat administration of water. Obtain medical advice immediately.

First Aid Comments:
Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.

All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.


Flash Point:
90.5 deg C (195 deg F) (Cleveland open cup) (2)

Lower Flammable (Explosive) Limit (LFL/LEL):
Not available

Upper Flammable (Explosive) Limit (UFL/UEL):
Not available

Autoignition (Ignition) Temperature:
Not available

Sensitivity to Mechanical Impact:
Probably not sensitive. Stable material.

Sensitivity to Static Charge:
No information is available on electrical conductivity. It is probably not sensitive, since it has a high flash point.

Fire Hazard Summary:
Combustible liquid. Can form explosive mixtures with air at, or above 90.5 deg C.

Extinguishing Media:
Carbon dioxide, dry chemical powder, alcohol foam, polymer foam, water spray or fog.

Fire Fighting Instructions:
Water spray or fog can be used to extinguish fires involving dipropylene glycol monoethyl ether (DPGEE), since it can be cooled below its flash point. Water spray can be used to absorb heat, keep containers cool and protect exposed material. If a leak or spill has not ignited, use water spray to disperse the vapours, dilute the spill to a nonflammable mixture and to protect personnel attempting to stop a leak. Water spray may be used to flush spills away from ignition sources.
DPGEE is only slightly hazardous to health. Firefighters may enter the area if positive pressure self-contained breathing apparatus (MSHA/NIOSH approved or equivalent) and full Bunker Gear is worn.


NFPA - Comments:
NFPA has no listing for this chemical in Codes 49 or 325.


Molecular Weight: 162.26

Conversion Factor:
1 ppm = 6.6 mg/m3; 1 mg/m3 = 0.15 ppm at 25 deg C (calculated)

Physical State: Liquid
Melting Point: Not available
Boiling Point: 193-195 deg C (379-383 deg F) at 760 mm Hg
Relative Density (Specific Gravity): 0.927 at 25 deg C (water = 1) (1)
Solubility in Water: Soluble in all proportions.
Solubility in Other Liquids: Soluble in a variety of organic solvents (characteristic of the chemical family).
Coefficient of Oil/Water Distribution (Partition Coefficient): Not available
pH Value: Not available
Viscosity-Kinematic: 3.34 centistokes at 25 deg C (2)
Vapour Density: 5.6 (air = 1)
Vapour Pressure: 0.04 kPa (0.3 mm Hg) at 25 deg C
Saturation Vapour Concentration: About 0.04% (400 ppm) at 25 deg C (calculated)
Evaporation Rate: Not available
Critical Temperature: Not available


Normally stable

Hazardous Polymerization:
Will not occur

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.

OXIDIZING AGENTS - Contact with DPGEE will increase the risk of fire and explosion.
STRONG ACIDS - May cause decomposition of ethers.

Hazardous Decomposition Products:
None reported

Conditions to Avoid:
Temperatures above 90.5 deg C

Corrosivity to Metals:
Not corrosive

Stability and Reactivity Comments:
Some glycol ethers can form peroxides during prolonged storage in contact with air. Formation of peroxides occur more readily in sunlight. The rate and extent of peroxide formation with DPGEE is unknown, but is expected to be low. This is not expected to pose any hazard.


LD50 (oral, rat): 3.71 g/kg (reported as 4 mL/kg) (1)

SKIN IRRITATION (rabbit): Repeated applications (10 in 14 days) only resulted in mild irritation. However, single applications (10 in 14 days) under a cuff caused burns. There was no evidence that toxic amounts had been absorbed.(1)

SKIN ABSORPTION (rabbit): Single doses of DPGEE were applied to the skin of rabbits for 24 hours under a cover. Applications of 5 mL/kg produced no deaths. At 10 mL/kg there were 7 deaths out of 10 animals; at 15 mL/kg all animals died. All animals exhibited transient weight loss. Narcosis was produced at all doses but was profound at higher doses.(1)

EYE IRRITATION (rabbit): Repeated application (one drop of DPGEE) for 5 days caused slight transitory irritation but no corneal injury.(1)

SHORT-TERM INHALATION (rat): Exposure to DPGEE at essentially saturated vapour concentration (about 400 ppm) for 7 hours produced irritation of eyes and nose and temporary weight loss. There was 1 death among 12 rats, presumably due to anesthesia (narcosis). Survivors recovered within 24 hours.(1)

NOTE: Animal toxicity data is based on unpublished data presented in reference (1).


Selected Bibliography:
(1) Patty's industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. John Wiley & Sons, 1982. p. 3975, 3992-3993
(2) Industrial solvents handbook. 3rd ed. Noyes Data Corporation, 1985. p. 430
(3) NIOSH pocket guide to chemical hazards. NIOSH, June 1994. p. 122-123
(5) Langhorst, M.L. Glycol Ethers--Validation Procedures for Tube/Pump and Dosimeter Monitoring Methods. American Industrial Hygiene Associal Journal. Vol. 45, no. 6 (1984). p. 416-424

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.

Review/Preparation Date: 1993-03-05

Revision Indicators:
TDG 1994-03-01
Fire fighting instructions 1995-01-01
Conditions to avoid 1995-01-01
Sensitivity to static charge 1995-10-01
Handling 1995-10-01
TLV comments 1995-11-01
Sampling 1995-11-01
EU class 1995-11-01
US transport 1995-11-01
Respiratory guidelines 1995-11-01
Sampling 1996-01-01
Resistance of materials 1998-05-01
Bibliography 1998-05-01
WHMIS disclosure list 2003-05-30
Carcinogenicity 2003-05-30
PEL-TWA transitional 2003-10-16

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