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1,4-DIOXANE ICSC: 0041
Date of Peer Review: April 1993

1,4-Diethylene dioxide
1,4-Diethyleneoxide
CAS # 123-91-1 C4H8O2
RTECS # JG8225000 Molecular mass: 88.1
UN # 1165
EC # 603-024-00-5
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Highly flammable.
NO open flames, NO sparks, and NO smoking. NO contact with strong oxidants. NO contact with hot surfaces.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Vapour/air mixtures are explosive. Risk of fire and explosion on contact with incompatible materials: see Chemical Dangers.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
AVOID ALL CONTACT!

Inhalation Headache. Nausea. Cough. Sore throat. Abdominal pain. Dizziness. Drowsiness. Vomiting. Unconsciousness.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
Skin MAY BE ABSORBED! Redness.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes Redness. Pain. Causes watering of the eyes.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water. Personal protection: complete protective clothing including self-contained breathing apparatus.
Airtight.
EU Classification
Symbol: F, Xn
R: 11-19-36/37-40-66
S: (2-)-9-16-36/37-46
Note: [D]
UN Classification
UN Hazard Class: 3
UN Pack Group: II
EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30S1165
NFPA Code: H2; F3; R1;
Fireproof. Separated from strong oxidants, strong acids. Cool. Dry. Keep in the dark. Store only if stabilized.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2004

SEE IMPORTANT INFORMATION ON BACK


1,4-DIOXANE ICSC: 0041
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID, WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.

CHEMICAL DANGERS:
The substance can form explosive peroxides. Reacts vigorously with strong oxidants and concentrated strong acids. Reacts explosively with some catalysts (e.g., Raney-nickel above 210C). Attacks many plastics.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 20 ppm as TWA; (skin) A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004).
MAK: 20 ppm, 73 mg/m; Peak limitation category: I(2); skin absorption (H); Carcinogen category: 4; Pregnancy risk group: D; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour and through the skin.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20C on spraying much faster.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes and the respiratory tract. The substance may cause effects on the central nervous system, liver and kidneys. Exposure to high vapour concentrations may result in unconsciousness.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The liquid defats the skin. This substance is probably carcinogenic to humans.
PHYSICAL PROPERTIES
Boiling point: 101C
Melting point: 12C
Relative density (water = 1): 1.03
Solubility in water: miscible
Vapour pressure, kPa at 20C: 4.1
Relative vapour density (air = 1): 3.0
Relative density of the vapour/air-mixture at 20C (air = 1): 1.08
Flash point: 12C
Auto-ignition temperature: 180C
Explosive limits, vol% in air: 2-22.5
Octanol/water partition coefficient as log Pow: -0.42
ENVIRONMENTAL DATA

NOTES
Use of alcoholic beverages enhances the harmful effect. Depending on the degree of exposure, periodic medical examination is suggested. The odour warning when the exposure limit value is exceeded is insufficient. Check for peroxides prior to distillation; render harmless if positive.
Card has been partly updated in April 2005. See sections Occupational Exposure Limits, EU classification.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2004
See Also:
        1,4-Dioxane (CHEMINFO)