The following information has been extracted from our CHEMINFO database, which also contains hazard control and regulatory information. [More about...] [Sample Record]

Access the complete CHEMINFO database by contacting CCOHS Client Services.


CHEMINFO Record Number: 669
CCOHS Chemical Name: trans-1,4-Dimethylcyclohexane

Dimethylcyclohexane (non-specific name)

CAS Registry Number: 2207-04-7
UN/NA Number(s): 2263
EU EINECS/ELINCS Number: 218-622-8
Chemical Family: Saturated alicyclic hydrocarbon / cycloalkane / cyclohexane / alkyl cyclohexane
Molecular Formula: C8-H16
Structural Formula: CH3-C6H10-CH3


Appearance and Odour:
Colourless liquid

Odour Threshold:
Not available

Warning Properties:
Insufficient information available for evaluation.

trans-1,4-Dimethylcyclohexane is a saturated alicyclic hydrocarbon. It has many similarities (properties and hazards) to other members of this group. Information specifically for trans-1,4-Dimethylcyclohexane is given when available. Otherwise information is based on related members of the group, such as cyclohexane or methylcyclohexane.

Uses and Occurrences:
Solvent, organic synthesis


Colourless liquid. FLAMMABLE LIQUID AND VAPOUR. Liquid may accumulate static charge. Vapour is heavier than air and may spread long distances and accumulate in low-lying areas. Distant ignition and flashback are possible. Liquid can float on water and may travel to distant locations and/or spread fire. Central nervous system depressant. High vapour concentrations may cause headache, nausea, dizziness, drowsiness, confusion, unconsciousness and death. Aspiration hazard. Swallowing or vomiting of the liquid may cause aspiration into the lungs.


Effects of Short-Term (Acute) Exposure

No specific information is available. The effects of trans-1,4-dimethylcyclohexane are probably similar to related alicyclic hydrocarbons such as methylcyclohexane. Therefore, trans-1,4-dimethylcyclohexane is probably a central nervous system depressant. High vapour concentrations may cause headache, lightheadedness, nausea, dizziness, drowsiness and confusion. Very high concentrations may cause unconsciousness and death.
Vapour may cause slight irritation to the nose and throat.

Skin Contact:
Direct contact with liquid may cause mild irritation.

Eye Contact:
Cyclohexanes are not known as eye irritants. Concentrated vapour may be irritating to the eyes. Splashes of liquid in the eyes may cause temporary redness and pain.

Animal toxicity information for alicyclic hydrocarbons indicates that these materials have very low toxicity if ingested, but cause diarrhea.(1) Extremely large doses would be required to cause symptoms of depression of central nervous system, as described for "inhalation" above.
trans-1,4-Dimethylcyclohexane can probably be aspirated into the lungs. Aspiration is the breathing of a material into the lungs when it is swallowed or vomited. Potentially fatal lung damage (pulmonary edema) can result.
Ingestion is not a typical route of occupational exposure.

Effects of Long-Term (Chronic) Exposure

SKIN CONTACT: Cyclohexanes dissolve skin oils. Repeated or prolonged contact may cause dermatitis (inflammation, reddening and swelling).
EFFECTS ON THE NERVOUS SYSTEM: There is no information specific to trans-1,4-dimethylcyclohexane. The related material cyclohexane, is not known for effects on the nervous system.


There is no human or animal information available.

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
There is no human or animal information available.

Reproductive Toxicity:
There is no human or animal information available.

The related isomer 1,2-dimethylcyclohexane was negative in two studies with animal embryo cells.(3)

Toxicologically Synergistic Materials:
There is no information available.

Potential for Accumulation:
Unlikely to accumulate since it is readily metabolized and excreted from the body.


This product is flammable. Take proper precautions (e.g. remove any sources of ignition). Remove source of contamination or move victim to fresh air. If breathing has stopped, trained personnel should begin artificial respiration or, if the heart has stopped, cardiopulmonary resuscitation (CPR) immediately. Obtain medical attention immediately.

Skin Contact:
Remove contaminated clothing, shoes and leather goods (e.g., watchbands, belts). Wash gently and thoroughly with water and non-abrasive soap for at least 5 minutes or until the chemical is removed. If irritation persists, obtain medical advice immediately. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
Quickly and gently blot or brush away excess chemical. Immediately flush the contaminated eye(s) with lukewarm, gently flowing water for 5 minutes or until the chemical is removed, while holding the eyelid(s) open. Obtain medical advice immediately.

Never give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. DO NOT INDUCE VOMITING. Have victim drink 240 to 300 mL (8 to 10 oz.) of water. If vomiting occurs naturally, have victim lean forward to reduce risk of aspiration. Repeat administration of water. Obtain medical attention immediately.

First Aid Comments:
Provide general supportive measures (comfort, warmth, rest). Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.

All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.


Flash Point:
11 deg C (51 deg F) (closed cup) (4)

Lower Flammable (Explosive) Limit (LFL/LEL):
Not available

Upper Flammable (Explosive) Limit (UFL/UEL):
Not available

Autoignition (Ignition) Temperature:
Not available for trans-1,4-dimethylcyclohexane. 304 deg C (579 deg F) has been reported for 1,4-dimethylcyclohexane (mixture of cis and trans isomers).(4)

Sensitivity to Mechanical Impact:
Probably not sensitive. Stable material.

Sensitivity to Static Charge:
Specific information is not available. By comparison to other hydrocarbons, trans-1,4-dimethylcyclohexane can accumulate static charge by flow or agitation, since hydrocarbons have low electrical conductivities. Vapour can be ignited by static discharge.

Fire Hazard Summary:
Flammable liquid. Can release vapours that form flammable or explosive mixtures with air at, or above 11 deg C. The vapour is heavier than air and may travel a considerable distance to a source of ignition and flash back to a leak or open container. Liquid can float on water and may travel to distant locations and/or spread fire. Can accumulate in confined spaces, resulting in a toxicity and explosion hazard. During a fire, irritating/toxic gases may be generated. Containers may explode in the heat of the fire.

Extinguishing Media:
Carbon dioxide, dry chemical powder, alcohol foam or polymer foam. Water may be ineffective because it will not cool trans-1,4-dimethylcyclohexane below its flash point. Fire fighting foams are the extinguishing agent of choice for most flammable liquid fires.

Fire Fighting Instructions:
Evacuate area and fight fire from a safe distance or protected location. Approach fire from upwind to avoid hazardous vapours and toxic decomposition products.
Stop leak before attempting to stop the fire. If the leak cannot be stopped, and if there is no risk to the surrounding area, let the fire burn itself out. If the flames are extinguished without stopping the leak, vapours could form explosive mixtures with air and reignite, causing an explosion.
Water can extinguish the fire if used under favourable conditions and when hose streams are applied by experienced firefighters trained in fighting all types of flammable liquid fires.
Containers may rupture in the heat of the fire. Isolate materials not yet involved in the fire and protect personnel. Move containers from fire area if this can be done without risk. Otherwise, fire-exposed containers or tanks should be cooled by application of hose streams and this should begin as soon as possible (within the first several minutes) and should concentrate on any unwetted portions of the container. If this is not possible, use unmanned monitor nozzles and immediately evacuate the area.
If a leak or spill has not ignited, use water spray in large quantities to disperse the vapours, to protect personnel attempting to stop a leak. Water spray can be used to dilute spills to nonflammable mixtures and to flush spills away from ignition sources. Solid streams of water may be ineffective and spread material.
For a massive fire in a large area, use unmanned hose holder or monitor nozzles; if this is not possible withdraw from fire area and allow fire to burn. Stay away from ends of tanks. Withdraw immediately in case of rising sound from venting safety device or any discolouration of tank due to fire.
Firefighters may enter the area if a positive pressure self-contained breathing apparatus (MSHA/NIOSH approved or equivalent) and full Bunker Gear is worn.


NFPA - Health: 2 - Intense or continued (but not chronic) exposure could cause temporary incapacitation or possible residual injury.
NFPA - Flammability: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions.
NFPA - Instability: 0 - Normally stable, even under fire conditions, and not reactive with water.


Molecular Weight: 112.22

Conversion Factor:
1 ppm = 4.58 mg/m3; 1 mg/m3 = 0.218 ppm at 25 deg C (calc.)

Physical State: Liquid
Melting Point: -37 deg C (-35 deg F)
Boiling Point: 119 deg C (246 deg F)
Relative Density (Specific Gravity): 0.766 (water = 1)
Solubility in Water: Insoluble
Solubility in Other Liquids: Soluble in most organic solvents
Coefficient of Oil/Water Distribution (Partition Coefficient): Not available
pH Value: Not applicable
Vapour Density: 3.86 (air = 1) (1)
Vapour Pressure: 2.8 kPa (21 mm Hg) at 21 deg C
Saturation Vapour Concentration: 28000 ppm (2.8%) at 21 deg C (calc.)
Evaporation Rate: Not available
Critical Temperature: Not available


Normally stable

Hazardous Polymerization:
Does not occur

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.

STRONG OXIDIZING AGENTS (e.g. peroxides, nitrates and perchlorates) - may react violently. Increased risk of fire and explosion.

Hazardous Decomposition Products:

Conditions to Avoid:
Heat, open flames, static discharge, sparks and other ignition sources.

Corrosivity to Metals:
Not corrosive


Effects of Short-Term (Acute) Exposure:

Dimethylcyclohexane appears to be slightly more toxic than methylcyclohexane. Mice exposed at 4360-5450 ppm (20-25 mg/L) to dimethylcyclohexane (isomer not specified) showed loss of righting reflex; 5450-6540 ppm (25-30 mg/L) caused death (duration of exposure not indicated).(1)


Selected Bibliography:
(1) Cavender, F. Alicyclic hydrocarbons. In: Patty's industrial hygiene and toxicology. 4th edition. Volume II. Toxicology. Part B. Edited by G.D. Clayton et al. John Wiley and Sons, 1994. p. 1267-1271, 1274-1275
(2) Carson, J.W., et al. Comparative relative molar response data on C5 to C8 hydrocarbons. Journal of Chromatographic Science. Vol. 11, no. 10 (1973). p. 503-508
(3) Rivedal, F., et al. Effects of hydrocarbons on transformation and intercellular communication in Syrian hamster embryo cells. Pharmacology and Toxicology. Vol. 71 (1992). p. 57-61
(4) Fire protection guide to hazardous materials. 13th ed. Edited by A.B. Spencer, et al. National Fire Protection Association, 2002. NFPA 325

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.

Review/Preparation Date: 1997-03-12

Revision Indicators:
US transport 1998-03-01
Bibliography 2003-04-14
NFPA (health) 2003-04-14
WHMIS disclosure list 2004-11-17

©2007 Canadian  Centre  for  Occupational  Health  &  Safety  E-mail:  Fax: (905) 572-2206  Phone: (905) 572-2981  
Mail:  250  Main  Street  East,  Hamilton  Ontario  L8N  1H6