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SECTION 1. CHEMICAL IDENTIFICATION

CHEMINFO Record Number: 60
CCOHS Chemical Name: Diethylene glycol n-hexyl ether

Synonyms:
Diethylene glycol hexyl ether
Diethylene glycol mono (n-hexyl) ether
Diethylene glycol monohexyl ether
3,6-Dioxa-1-dodecanol
2-[2-(hexyloxy)ethoxy]ethanol
DEGHE
Ether monohexylique du diéthylène glycol

Trade Name(s):
Hexyl Carbitol

CAS Registry Number: 112-59-4
RTECS Number(s): KL2625000
EU EINECS/ELINCS Number: 203-988-3
Chemical Family: Aliphatic ether alcohol / aliphatic glycol ether / aliphatic diglycol ether / diethylene glycol ether / diethylene glycol monoether
Molecular Formula: C10-H22-03
Structural Formula: CH3-(CH2)4-CH2-O-CH2-CH2-O-CH2-CH2-OH

SECTION 2. DESCRIPTION

Appearance and Odour:
Colourless liquid

Odour Threshold:
Information not available

Warning Properties:
Insufficient information for evaluation.

Uses and Occurrences:
High-boiling solvent


SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW:
Colourless liquid. No unusual hazard in a fire situation. Can probably burn if strongly heated. Mild central nervous system depressant. May cause headache, nausea, dizziness, drowsiness, incoordination. Causes skin and eye irritation.



POTENTIAL HEALTH EFFECTS

Effects of Short-Term (Acute) Exposure

Inhalation:
No adverse effects on humans have been reported. This material does not tend to form vapours at normal room temperatures and appears to have a low acute toxicity in animal tests. Therefore, no short-term health effects are expected unless the material is heated or mists are formed. In severe cases, effects might be like those described for ingestion exposures.

Skin Contact:
Mild to moderate irritant. Should not cause injury unless exposure is severe. Can be absorbed through the skin, but exposure must be severe before health effects would be expected. In severe cases, effects might be like those described for ingestion.
Although allergic reactions to glycols are rare, contact sensitivity to some glycols has been reported. There is no information on diethylene glycol n-hexyl ether in this regard.

Eye Contact:
Liquid or mist is expected to be moderate to severe eye irritant. The undiluted chemical caused severe eye irritation and corneal injury in 2 different studies with rabbits.(3,4)

Ingestion:
No cases have been reported, but early symptoms are expected to be similar to those of alcohol intoxication. Vomiting, headache, loss of co-ordination, rapid respiration and heart rate, low blood pressure, muscle tenderness, and unconsciousness may follow. Large or repeated amounts may affect kidney function.

Effects of Long-Term (Chronic) Exposure

No adverse human experience has been reported.

SKIN: Can be absorbed through the skin in toxic amounts if contact is extensive and prolonged.

Carcinogenicity:

No information available

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
The available evidence suggests that most diethylene glycol ethers do not cause teratogenic or embryotoxic effects. Although, there is some evidence that the monomethyl ether causes teratogenic and embryotoxic effects in animals (see CHEMINFO 50E).

Reproductive Toxicity:
No information available

Mutagenicity:
No information available

Toxicologically Synergistic Materials:
No information available

Potential for Accumulation:
None. Ethers of diethylene glycol do not appear to be metabolized to oxalic acid.


SECTION 4. FIRST AID MEASURES

Inhalation:
If symptoms occur, remove source of contamination or move victim to fresh air. Obtain medical advice immediately.

Skin Contact:
As quickly as possible, flush contaminated area with lukewarm, gently running water for at least 20 minutes, or until the chemical is removed. Under running water, remove contaminated clothing, shoes, and leather goods (e.g. watchbands, belts). Obtain medical attention immediately. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
Immediately flush the contaminated eye(s) with lukewarm, gently flowing water for at least 20 minutes, or until the chemical is removed, while holding the eyelid(s) open. Take care not to rinse contaminated water into the unaffected eye. Obtain medical attention immediately.

Ingestion:
Never give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. Have victim rinse mouth thoroughly with water. DO NOT INDUCE VOMITING. Have victim drink 240 to 330 ml (8 to 10 oz.) of water to dilute material in stomach. Obtain medical attention immediately.

First Aid Comments:
Provide general supportive measures (comfort, warmth, rest). Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact. All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the particular workplace.



SECTION 5. FIRE FIGHTING MEASURES

Flash Point:
140.6 deg C (285 deg F) (open cup) (1)

Lower Flammable (Explosive) Limit (LFL/LEL):
Not available

Upper Flammable (Explosive) Limit (UFL/UEL):
Not available

Autoignition (Ignition) Temperature:
Not available

Sensitivity to Mechanical Impact:
Probably not sensitive. Stable material.

Sensitivity to Static Charge:
Probably not sensitive. High flash point.

Fire Hazard Summary:
This material can probably burn if strongly heated.

Extinguishing Media:
Carbon dioxide, alcohol foam, dry chemical, water spray or fog (see below) may be effective.

Fire Fighting Instructions:
Water spray, fog or alcohol foam can be used to extinguish fires involving diethylene glycol n-hexyl ether. Water or foam may cause frothing. However, a water spray, fog that is gently applied to the surface of the liquid, preferably with a fine spray, fog nozzle, will cause frothing that will blanket and extinguish the fire.
Water spray or mist can be used to absorb heat, keep containers cool and protect exposed material. If a leak or spill has not ignited, use water spray to disperse the vapours and to protect personnel attempting to stop a leak. Water spray may be used to flush spills away from ignition sources.
Diethylene glycol-n-hexyl ether in only slightly hazardous to health. Firefighters may enter the area if positive pressure self-contained breathing apparatus (MSHA/NIOSH approved or equivalent) and full Bunker Gear is worn.



NATIONAL FIRE PROTECTION ASSOCIATION (NFPA) HAZARD IDENTIFICATION

NFPA - Comments:
NFPA has no listing for this chemical in Codes 49 or 325.


SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Molecular Weight: 190.32

Conversion Factor:
1 ppm = 7.78 mg/m3; 1 mg/m3 = 0.129 ppm at 25 deg C

Physical State: Liquid
Melting Point: -33.3 deg C (-27.9 deg F) (freezing point)
Boiling Point: 259.1 deg C (498.4 deg F)
Relative Density (Specific Gravity): 0.935 at 25 deg C (water = 1)
Solubility in Water: Slightly to moderately soluble (1.7 g/100 mL) (4)
Solubility in Other Liquids: Information not available
Coefficient of Oil/Water Distribution (Partition Coefficient): Not available
pH Value: Not available
Vapour Density: 6.56 (air = 1)
Vapour Pressure: Less than 0.0013 kPa (less than 0.01 mm Hg) at 25 deg C
Saturation Vapour Concentration: Less than 13 ppm at 25 deg C
Evaporation Rate: No specific information - expected to be low
Critical Temperature: Not available

Other Physical Properties:
VISCOSITY-DYNAMIC: 8.6 centipoises (8.6 mPa.s) (5)


SECTION 10. STABILITY AND REACTIVITY

Stability:
Normally stable

Hazardous Polymerization:
Will not occur

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.


OXIDIZING MATERIALS - increased risk of fire and explosion.

Hazardous Decomposition Products:
None reported

Conditions to Avoid:
Temperatures above 140 deg C

Corrosivity to Metals:
Not corrosive


SECTION 11. TOXICOLOGICAL INFORMATION

LD50 (oral, rat): 4920 mg/kg (3)
LD50 (oral, male rat): 4600 mg/kg (reported as 4.92 mL/kg) (4)
LD50 (oral, female rat): 3400 mg/kg (reported as 3.73 mL/kg) (4)
LD50 (dermal, rat): 1500 mg/kg (3)
LD50 (dermal, male rabbit): 2000 mg/kg (reported as 2.14 mL/kg) (4)
LD50 (dermal, female rabbit): 2200 mg/kg (reported as 2.37 mL/kg) (4)

Signs and symptoms of intoxication noted in LD50 tests included salivation, sluggishness, unsteadiness and unconsciousness.

EYE IRRITATION (rabbit): Application of 0.005 mL, 0.1 mL or 0.5 mL of undiluted chemical resulted in severe irritation and corneal injury in 2 different studies.(3,4)

SKIN IRRITATION (rabbit): Application of 0.01 mL or 0.5 mL of undiluted chemical uncovered for 24 hours resulted in moderate or severe irritation.(2,3) Application of 0.5 mL of undiluted chemical for 4 hours resulted in slight irritation.(4)

SHORT-TERM INHALATION (rat): Exposure for 6 or 8 hours to essentially saturated vapour concentrations at room temperature resulted in no significant ill effects or deaths.(3,4)


SECTION 16. OTHER INFORMATION

Selected Bibliography:
(1) Patty's industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. John Wiley and Sons, 1982. p. 3966-3967
(2) Draize, J.H., et al. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. Journal of Pharmacology and Experimental Therapeutics. Vol. 82 (1944). p. 377-390
(3) Smyth, H.F., et al. Range-finding toxicity data : list IV. A.M.A. Archives of Industrial Hygiene and Occupational Medicine. Vol. 4 (1951)
(4) Ballantyne, B., et al. The comparative acute toxicity and primary irritancy of the monohexyl ethers of ethylene and diethylene glycol. Vet. Hum. Toxicol. Vol. 29, no. 5 (Oct. 1987). p. 361-366
(5) HSDB record for diethylene glycol hexyl ether. Complete update on 01/16/85
(6) Forsberg, K., et al. Quick selection guide to chemical protective clothing. 4th ed. Van Nostrand Reinhold, 2002
(7) European Communities (EC). Commission Directive 2004/73/EC. Apr. 29, 2004

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.


Review/Preparation Date: 1993-03-12

Revision Indicators:
TDG 1994-02-01
Fire fighting instructions 1995-01-01
HANDLING AND STORAGE 1995-01-01
Sampling 1995-08-01
Protective equipment 1995-08-01
EU number 1995-08-01
US Transport 1995-08-01
Resistance of materials 1998-05-01
Bibliography 1998-05-01
Carcinogenicity 2003-05-30
PEL-TWA transitional 2003-10-21
Resistance of materials for PPE 2004-03-15
Bibliography 2005-01-26



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