The following information has been extracted from our CHEMINFO database, which also contains hazard control and regulatory information. [More about...] [Sample Record]

Access the complete CHEMINFO database by contacting CCOHS Client Services.


CHEMINFO Record Number: 71
CCOHS Chemical Name: Diethylene glycol ethyl vinyl ether

1-(2-Ethoxyethoxy)-2-vinyloxy ethane
2-Ethoxyethyl 2-(vinyloxy)ethyl ether
Ether diéthylvinyl du diéthylène glycol
Vinyl ethyl Carbitol

CAS Registry Number: 10143-53-0
Chemical Family: Aliphatic glycol diether / aliphatic diglycol diether / diethylene glycol ether / diethylene glycol diether
Molecular Formula: C8 H16 O3
Structural Formula: CH2=CH-O-CH2-CH2-O-CH2-CH2-O-CH2-CH3


Appearance and Odour:
Colourless liquid

Odour Threshold:
No information available

Warning Properties:
Information not available for evaluation.

Uses and Occurrences:


Colourless liquid. FLAMMABLE LIQUID AND VAPOUR. Vapour is heavier than air and may spread long distances. Distant ignition and flashback are possible. Mild central nervous system depressant. May cause headache, nausea, dizziness, drowsiness and incoordination.


Effects of Short-Term (Acute) Exposure

No adverse effects on humans have been reported. This material does not tend to form vapours at normal room temperatures and appears to have a low acute toxicity in animal tests. Therefore, no short-term health effects are expected unless the material is heated or mists are formed. In severe cases, effects might be like those described for ingestion exposures, below.

Skin Contact:
Does not cause irritation and has not been reported to cause sensitization. Although allergic reactions to glycols are rare, contact sensitivity to some glycols has been reported. There is no information available on diethylene glycol ethyl vinyl ether. Can be absorbed through the skin, but exposure must be severe before health effects would be reported.

Eye Contact:
Liquid is essentially non-irritating. It was rated 1 on a scale of 10 in rabbit eye tests.(1)

No cases have been reported, but early symptoms are expected to be similar to those of alcohol intoxication. Vomiting, bluish colouring of the skin (cyanosis), headache, rapid respiration and heart rate, low blood pressure, muscle tenderness, and unconsciousness may follow. Large or repeated amounts may affect kidney function.

Effects of Long-Term (Chronic) Exposure

No adverse human experience has been reported.

SKIN: Can be absorbed through the skin in toxic amounts if contact is extensive and prolonged.


No human or animal information is available.

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
The available evidence suggests that most diethylene glycol ethers do not cause reproductive effects. There is some evidence that the monomethyl ether causes reproductive effects in animals. (See CHEMINFO record no. 50E for details).

Reproductive Toxicity:
No human or animal information is available.

No information is available.

Toxicologically Synergistic Materials:
No information is available.

Potential for Accumulation:
Probably none. Ethers of diethylene glycol do not appear to be metabolized to oxalic acid.


If symptoms occur, remove source of contamination or move victim to fresh air. Obtain medical advice immediately.

Skin Contact:
Flush contaminated area with lukewarm, gently running water for at least 5 minutes, or until the chemical is removed. Obtain medical advice immediately. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
If irritation occurs, immediately flush the contaminated eye(s) with lukewarm, gently flowing water for at least 5 minutes, or until the chemical is removed, while holding the eyelid(s) open. If irritation persists, obtain medical attention immediately.

Never give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. Have victim rinse mouth thoroughly with water. DO NOT INDUCE VOMITING. Have victim drink 240 to 300 ml (8 to 10 oz.) of water to dilute material in stomach. Obtain medical attention immediately.

First Aid Comments:
Provide general supportive measures (comfort, warmth, rest). Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact. All first aid procedures should be periodically reviewed by a doctor familiar with the material and its condition of use in the particular workplace.


Flash Point:
32.8 deg C (91 deg F) (open cup)

Lower Flammable (Explosive) Limit (LFL/LEL):

Upper Flammable (Explosive) Limit (UFL/UEL):
Not available

Autoignition (Ignition) Temperature:
201 deg C (394 deg F)

Sensitivity to Mechanical Impact:
Not sensitive. Stable material.

Sensitivity to Static Charge:
No information is available on electrical conductivity. However, vapours in the flammable range may be ignited by a static discharge of sufficient energy.

Fire Hazard Summary:
Flammable liquid. Can release vapours that form explosive mixtures with air at, or above, 32 deg C. Vapour is heavier than air and may travel a considerable distance to a source of ignition and flash back to a leak or open container.

Extinguishing Media:
Carbon dioxide, dry chemical powder, alcohol foam. Water may be ineffective, since it may not cool diethylene glycol ethyl vinyl ether below its flash point.

Fire Fighting Instructions:
Diethylene glycol ethyl vinyl ether is soluble in water and has a moderately low flash point. Water may be ineffective for fighting fires involving this compound, unless used under favourable conditions by experienced fire fighters trained in fighting all types of flammable liquid fires. However, water may be used to dilute the liquid to the point where it is no longer flammable.
Also, water can be used in the form of a spray or mist to absorb heat, keep containers cool and protect exposed material. If a spill or leak has not ignited, use water spray to disperse the vapours and to protect personnel attempting to stop a leak. Water spray may be used to flush spills away from ignition sources.
Fire fighters may enter the area if positive pressure self-contained breathing apparatus (MSHA/NIOSH approved or equivalent) and full Bunker Gear is worn.


NFPA - Comments:
NFPA has no listing for this chemical in Codes 49 or 325.


Molecular Weight: 160.24

Conversion Factor:
1 ppm = 6.54 mg/m3; 1 mg/m3 = 0.153 ppm at 25 deg C (calculated)

Physical State: Liquid
Melting Point: -80 deg C (-112 deg F) (sets to a glass) (freezing point)
Boiling Point: 191.2 deg C (376.2 deg F)
Relative Density (Specific Gravity): 0.941 at 20 deg C (water = 1)
Solubility in Water: Soluble (approx. 9.4% at 20 deg C)
Solubility in Other Liquids: Soluble in all proportions in ethyl alcohol and many solvents.
Coefficient of Oil/Water Distribution (Partition Coefficient): Not available
pH Value: Not available
Vapour Density: 5.53 (air = 1)
Vapour Pressure: 0.027 kPa (0.2 mm Hg) at 20 deg C
Saturation Vapour Concentration: Approximately 300 ppm at 25 deg C and 760 mm Hg
Evaporation Rate: No specific data -- expected to be low
Critical Temperature: Not available


Normally stable

Hazardous Polymerization:
Will not occur

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.

OXIDIZING MATERIALS - Possible risk of fire.

Hazardous Decomposition Products:
None reported

Conditions to Avoid:
Static spark, heat

Corrosivity to Metals:
Not corrosive


LD50 (oral, rat): 10,633 mg/kg (reported as 11.3 mL/kg) (1)
LD50 (dermal, rabbit): 7914 (reported as 8.41 mg/kg) (1)

EYE IRRITATION (rabbit): Essentially non-irritating to rabbit eyes (rated 1 on a scale of 10 in rabbit eye tests).(1)

SKIN IRRITATION (rabbit): Open Draize test - 10 mg/24 hours; mildly irritating to rabbit skin (rated 2 on a scale of 10 in rabbit irritation tests).(1,2)

SHORT-TERM INHALATION: No rats exposed to essentially saturated vapours for 8 hours died.(1)


Selected Bibliography:
(1) Clayton, G.D.; Clayton, F.E., eds. Patty's industrial hygiene and toxicology. 3rd revised ed. Vol. 2C : toxicology. John Wiley and Son, Inc., 1982. p. 3967-3968
(2) RTECS record for ether, 2-ethoxyethyl 2-(vinyloxy)ethyl. Last updated: 9009

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.

Review/Preparation Date: 1993-03-09

Revision Indicators:
TDG 1994-02-01
Fire fighting instructions 1995-01-01
Conditions to avoid 1995-01-01
EU class 1995-10-01
US transport 1995-10-01
Sampling 1995-10-01
Protective equipment 1995-10-01
Respiratory guidelines 1995-10-01
Resistance of materials 1995-10-01
Bibliography 1995-10-01
Synonyms 1995-10-01
Sensitivity to static charge 1995-10-01
Handling 1995-10-01
WHMIS disclosure list 2003-05-30
Carcinogenicity 2003-05-30
PEL-TWA transitional 2003-10-21

©2007 Canadian  Centre  for  Occupational  Health  &  Safety  E-mail:  Fax: (905) 572-2206  Phone: (905) 572-2981  
Mail:  250  Main  Street  East,  Hamilton  Ontario  L8N  1H6