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International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 1 (1972) (p. 61)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

The carcinogenicity of chloroform has been investigated only in mice in experiments involving a small number of animals at risk. Nevertheless among these the frequency of liver tumours was high. There is no evidence of carcinogenicity for organs other than the liver, but the experiments were shorter than the life-span of the animals. An experiment involving single or a few exposures of newborn mice gave negative results. An assessment of the carcinogenicity of chloroform awaits further experimental evidence.

5.2 Human carcinogenicity data

Chloroform entails several sources of exposure for humans. No long-term follow-up studies in men exposed to chloroform have been reported.

Subsequent evaluations: Vol. 20 (1979); Suppl. 7 (1987); Vol. 73 (1999)

Last updated: 30 September 1999

See Also:
        Chloroform (CHEMINFO)
        Chloroform (EHC 163, 1994)
        Chloroform (IARC Summary & Evaluation, Supplement 7, 1987)
        Chloroform (IARC Summary & Evaluation, Volume 20, 1979)
        Chloroform (ICSC)
        Chloroform (PIM 121)