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2-CHLORO-1-NITROBENZENE ICSC: 0028
Date of Peer Review: October 2002

o-Chloronitrobenzene
o-Nitrochlorobenzene
1-Chloro-2-nitrobenzene
CAS # 88-73-3 C6H4ClNO2
RTECS # CZ0875000 Molecular mass: 157.6
UN # 1578
EC #
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames. NO contact with flammable substances.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Finely dispersed particles form explosive mixtures in air.
Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting.

EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE!

Inhalation Blue lips or finger nails. Blue skin. Dizziness. Headache. Nausea. Shortness of breath. Confusion. Convulsions. Unconsciousness.
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin MAY BE ABSORBED! (Further see Inhalation).
Protective gloves. Protective clothing.
First rinse with plenty of water, then remove contaminated clothes and rinse again. Refer for medical attention.
Eyes Redness. Pain.
Safety goggles or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion (See Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT absorb in saw-dust or other combustible absorbents. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus.
Do not transport with food and feedstuffs.
EU Classification
UN Classification
UN Hazard Class: 6.1
UN Pack Group: II
EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S1578-S
NFPA Code: H3; F1; R1;
Separated from combustible and reducing substances, food and feedstuffs.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2004

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2-CHLORO-1-NITROBENZENE ICSC: 0028
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
YELLOW TO GREEN CRYSTALS, WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
Dust explosion possible if in powder or granular form, mixed with air.

CHEMICAL DANGERS:
The substance decomposes on burning producing toxic and corrosive fumes (nitrogen oxides, chlorine - see ICSC0126, hydrogen chloride - see ICSC0163, phosgene - see ICSC0007). The substance is a strong oxidant and reacts with combustible and reducing materials.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established. (See Notes). BEI issued
MAK: skin absorption (H); Carcinogen category: 3B; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is mildly irritating to the eyes. The substance may cause effects on the blood, resulting in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the blood and liver, resulting in the formation of methaemoglobin, anaemia and liver impairment.
PHYSICAL PROPERTIES
Boiling point: 246C
Melting point: 33C
Density: 1.4 g/cm
Solubility in water: none
Vapour pressure, kPa at 20C: 0.6
Relative vapour density (air = 1): 5.4
Relative density of the vapour/air-mixture at 20C (air = 1): 1.03
Flash point: 124C c.c.
Auto-ignition temperature: 487C
Explosive limits, vol% in air: 1.15-13.1
Octanol/water partition coefficient as log Pow: 2.24
ENVIRONMENTAL DATA
The substance is harmful to aquatic organisms.
NOTES
TLV (as para-nitrochlorobenzene): 0.1 ppm (skin) A3 (confirmed animal carcinogen with unknown relevance to humans) (ACGIH 2004). Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Rinse contaminated clothes (fire hazard) with plenty of water.
Card has been partly updated in April 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2004