International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 20 (1979) (p. 67)
CAS No.: 143-50-0
Chem. Abstr. Name: 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Chlordecone was tested in one experiment in mice and in two in rats by
oral administration: it produced hepatocellular carcinomas in males
and females of both species.
Chlordecone impairs fertility and is foetotoxic.
5.2 Human data
No case reports or epidemiological studies were available to the
The extensive production and the widespread use of chlordecone and its
persistence in the environment (where it may also occur as a result of
degradation of the pesticide mirex) indicate that human exposure
occurs. This is confirmed by many reports of its occurrence in human
body fluids. A group of highly exposed workers is known to exist.
Oligospermia with hypomobility of the sperm has been reported in
heavily exposed workers.
There is sufficient evidence that chlordecone is carcinogenic in mice
and rats. In the absence of adequate data in humans, it is reasonable,
for practical purposes, to regard chlordecone as if it presented a
carcinogenic risk to humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 59: Group 2B)
For definition of the terms, see Preamble Evaluation.
- Compound 1189
- ENT 16391
- GC 1189
Last updated: 31 March 1998
Chlordecone (EHC 43, 1984)