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2-CHLOROACETOPHENONE ICSC: 0128
Date of Peer Review: October 2002

2-Chloro-1-phenylethanone
alpha-Chloroacetophenone
Phenacyl chloride
CAS # 532-27-4 C8H7ClO / C6H5COCH2Cl
RTECS # AM6300000 Molecular mass: 154.6
UN # 1697
EC #
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION

In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
STRICT HYGIENE!

Inhalation Burning sensation. Cough. Sore throat. Nausea. Shortness of breath.
Local exhaust or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Skin Redness. Pain.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Redness. Pain. Blurred vision. Permanent partial loss of vision.
Safety spectacles, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Burning sensation.
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give plenty of water to drink. Give a slurry of activated charcoal in water to drink. Refer for medical attention. Rest.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Sweep spilled substance into sealable, plastic containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: self-contained breathing apparatus.)
Do not transport with food and feedstuffs.
EU Classification
UN Classification
UN Hazard Class: 6.1
UN Pack Group: II
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61GT2-II
NFPA Code: H 2; F 1; R 0;
Separated from food and feedstuffs. Keep in a well-ventilated room.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 1999

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2-CHLOROACETOPHENONE ICSC: 0128
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS TO GREY CRYSTALS.

CHEMICAL DANGERS:
The substance decomposes on burning producing toxic and corrosive fumes including hydrogen chloride.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.05 ppm; A4; (ACGIH 2002).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and by ingestion.

INHALATION RISK:
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
Causes watering of the eyes. The substance is severely irritating to the eyes. The substance is irritating to the skin and the respiratory tract. Inhalation of vapour or aerosol may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.
PHYSICAL PROPERTIES
Boiling point: 244-245C
Melting point: 54-59C
Density: 1.3 g/cm^3
Solubility in water, g/100 ml at 25C: 1.64
Vapour pressure, Pa at 20C: 0.7
Relative vapour density (air = 1): 5.3
Relative density of the vapour/air-mixture at 20C (air = 1): 1.0
Flash point: 118C c.c.
Octanol/water partition coefficient as log Pow: 2.08
ENVIRONMENTAL DATA

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. The odour warning when the exposure limit value is exceeded is insufficient. Chemical Mace, CAP, CN are trade names. Do NOT take working clothes home.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 1999