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SECTION 1. CHEMICAL IDENTIFICATION

CHEMINFO Record Number: 581
CCOHS Chemical Name: 1-Octanol

Synonyms:
Alcohol C-8
Capryl alcohol
Caprylic alcohol
Heptyl carbinol
1-Hydroxyoctane
Normal-primary octyl alcohol
Octanol (non-specific name)
n-Octanol
Octyl alcohol (non-specific name)
n-Octyl alcohol
Primary octyl alcohol
Alcool n-octylique

Chemical Name French: 1-Octanol
CAS Registry Number: 111-87-5
RTECS Number(s): RH6550000
EU EINECS/ELINCS Number: 203-917-6
Chemical Family: Saturated primary aliphatic alcohol / primary alkanol / primary alkyl alcohol / octanol / octyl alcohol
Molecular Formula: C8-H18-O
Structural Formula: CH3-CH2-(CH2)5-CH2-OH

SECTION 2. DESCRIPTION

Appearance and Odour:
Clear, oily liquid with a sweet, penetrating, aromatic odour.(2,3)

Odour Threshold:
2 ppb (0.002 ppm) (recognition) (4). Also reported as 0.131 ppm (0.69 mg/m3) (octyl alcohol - no isomer specified) (5)

Warning Properties:
GOOD - odour threshold is less than 0.0025 times the WEEL.

Composition/Purity:
1-Octanol is available in a number of grades of 98% up to 100%.

Uses and Occurrences:
1-Octanol is used in the manufacture of perfumes and other chemicals; to mask industrial odours; for formulating wetting and foam control agents; as a flavouring agent in foods; as a solvent in resistant coatings and linings; as an ingredient in pesticide formulations; to improve the compatibility of calcium carbonate filler in various plastics; and in a cleaning composition for engine carburetors.(2,3,6)
1-Octanol is a component of several essential oils, such as green tea, grapefruit, California orange, violet leaves and bitter orange. It may be released into the environment during its manufacture, transport, use and disposal.(3)


SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW:
Clear, oily liquid with a sweet, penetrating, aromatic odour. COMBUSTIBLE LIQUID AND VAPOUR. Mild central nervous system depressant. High concentrations of mist may cause headache, nausea, dizziness, drowsiness, incoordination and confusion. EYE IRRITANT. Causes moderate eye irritation. Aspiration hazard. Swallowing or vomiting of the liquid may cause aspiration (breathing) into the lungs.



POTENTIAL HEALTH EFFECTS

Effects of Short-Term (Acute) Exposure

Inhalation:
1-Octanol does not readily form a vapour at room temperature. Vapours from heated solutions or mists may cause irritation of the nose and throat. High concentrations of mist may cause headache, nausea, dizziness, and drowsiness. These are symptoms of slight depression of the central nervous system (CNS).
Twenty-four volunteers, half of whom were particularly sensitive to the effects of chemicals, were exposed to 0.1 or 6.4 ppm 1-octanol for 4 hours and monitored for neurobehavioural and neuropsychological effects. Although some minor effects were noted, it was not possible to determine if the effects were caused by the annoying odour or sensory irritation.(36) Brief exposure (10 minutes) to 50 ppm is expected to produce intolerable nose and throat irritation in humans, based on animal information.
Irritant and CNS effects have also been described for some other alcohols (1-butanol and mixed pentanol isomers).

Skin Contact:
1-Octanol is a no to mild irritant, based on animal and human information.
Undiluted 1-octanol was not irritating in a test using 27 or 28 volunteers.(22) In another study, there was no evidence of skin irritation when 2% octanol (isomer unspecified) in petrolatum was tested on 25 volunteers.(21) In a study, which is not available in English, application of 50% 1-octanol in vaseline caused moderate irritation.(37, unconfirmed) There are insufficient details available to evaluated this report.
Skin absorption only occurs to a slight extent (11) and harmful effects are not expected by this route of exposure.

Eye Contact:
1-Octanol is a moderate eye irritant, based on animal and limited human information.
Octanol (isomer unspecified) caused temporary injury to the outer layer of the eye (corneal epithelium). Recovery occurred in 48 hours.(24) Brief exposure (10 minutes) to 50 ppm vapour is expected to produce intolerable eye irritation, based on animal information.

Ingestion:
1-Octanol is not expected to be toxic if ingested based on animal toxicity values. If ingested in large amounts, it can probably cause effects resembling "alcohol" intoxication such as headache, dizziness, confusion, nausea and vomiting. In severe cases, unconsciousness and coma may result. Specific information was not located for 1-octanol, but related alcohols generally can cause these effects.
1-Octanol may be be aspirated into the lungs during ingestion or vomiting, resulting in severe lung damage (edema) and, in some cases, respiratory and/or cardiac arrest and death. Ingestion is not a typical route of occupational exposure.

Effects of Long-Term (Chronic) Exposure

Skin:
Repeated or prolonged contact can probably cause dermatitis (dry, cracked, thickened, reddened skin).

Skin Sensitization:
In an unpublished study, no evidence of sensitization was observed in 25 volunteers exposed to 2% in petrolatum.(1, unconfirmed)

Carcinogenicity:

No human or animal information was located.

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
No human information was located. 1-Octanol did not cause any developmental effects in inhalation and oral exposure studies using rats.

Reproductive Toxicity:
No human or animal information was located.

Mutagenicity:
The limited evidence available does not indicate that 1-octanol is a mutagen. No human or animal information was located. Positive results were obtained in cultured mammalian cells and negative results were obtained in bacteria.

Toxicologically Synergistic Materials:
Alcohols may interact synergistically with chlorinated solvents (e.g. carbon tetrachloride), aromatic hydrocarbons (e.g. xylene), or dithiocarbamates (e.g. disulfiram). 1-Octanol has enhanced the skin absorption of melatonin in hairless rats.

Potential for Accumulation:
Probably does not accumulate. Primary alcohols are generally broken down or transformed into other chemicals in the body and excreted.


SECTION 4. FIRST AID MEASURES

Inhalation:
If symptoms are experienced, remove source of contamination or move victim to fresh air. Obtain medical advice.

Skin Contact:
Remove contaminated clothing, shoes and leather goods (e.g. watchbands, belts). Quickly and gently blot or brush away excess chemical. Wash gently and thoroughly with lukewarm, gently flowing water and non-abrasive soap for 5 minutes. If irritation persists, repeat flushing and obtain medical attention. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
Quickly and gently blot or brush chemical off the face. Immediately flush the contaminated eye(s) with lukewarm, gently flowing water for 15-20 minutes, while holding the eyelid(s) open. If a contact lens is present, DO NOT delay irrigation or attempt to remove the lens until flushing is done. Take care not to rinse contaminated water into the unaffected eye or onto the face. Immediately obtain medical attention.

Ingestion:
NEVER give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. DO NOT INDUCE VOMITING. Have victim rinse mouth thoroughly with water. If vomiting occurs naturally, have victim lean forward to reduce risk of aspiration. Have victim rinse mouth with water again. Immediately obtain medical attention.

First Aid Comments:
Provide general supportive measures (comfort, warmth, rest).
Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.
All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.



SECTION 5. FIRE FIGHTING MEASURES

Flash Point:
81 deg C (178 deg F) (closed cup) (2,7-9)

Lower Flammable (Explosive) Limit (LFL/LEL):
Not available

Upper Flammable (Explosive) Limit (UFL/UEL):
Not available

Autoignition (Ignition) Temperature:
Not available

Sensitivity to Mechanical Impact:
Stable material. Not sensitive.

Sensitivity to Static Charge:
1-Octanol will not accumulate static charge since it has a high electrical conductivity. It will probably not be ignited by a static charge since the flash point is high.

Electrical Conductivity:
(1.4 X 10(7) pS/m) (9)

Combustion and Thermal Decomposition Products:
Aldehydes and other irritant gases, which may include unburned alcohol and toxic constituents.

Fire Hazard Summary:
Combustible liquid. Can form explosive mixtures at, or above 81 deg C. During a fire, irritating/toxic smoke and fumes may be generated. Closed containers may rupture violently and suddenly release large amounts of product when exposed to fire or excessive heat for a sufficient period of time.

Extinguishing Media:
Carbon dioxide, dry chemical powder, appropriate foam, water spray or fog.(13) "Multipurpose " alcohol-resistant foams are recommended for use on flammable polar liquids, such as 1-octanol.(7) Fire fighting foam manufacturers should be consulted for recommendations regarding types of foams and application rates.

Fire Fighting Instructions:
Evacuate area and fight fire from a safe distance or protected location. Approach fire from upwind to avoid toxic decomposition products.
Closed containers may rupture violently when exposed to the heat of fire. If possible, isolate materials not yet involved in the fire, and move containers from fire area if this can be done without risk, and protect personnel. Otherwise, fire-exposed containers or tanks should be cooled by application of hose streams. Application should begin as soon as possible (within the first several minutes) and should concentrate on any unwetted portions of the container. If this is not possible, use unmanned monitor nozzles and immediately evacuate the area.
If a leak or spill has not ignited, use water spray in large quantities to disperse the vapours and to protect personnel attempting to stop a leak. Water spray can be used to dilute spills to non-flammable mixtures and flush spills away from ignition sources. Solid streams of water may be ineffective and spread material. For a massive fire in a large area, use unmanned hose holder or monitor nozzles; if this is not possible withdraw from fire area and allow fire to burn. Stay away from ends of tanks, but be aware that flying material from ruptured tanks may travel in any direction. Withdraw immediately in case of rising sound from venting safety device or any discolouration of tank due to fire.

Protection of Fire Fighters:
1-Octanol is only slightly hazardous to health. Firefighters may enter the area if positive pressure self-contained breathing apparatus (NIOSH approved or equivalent) and full Bunker Gear is worn.



NATIONAL FIRE PROTECTION ASSOCIATION (NFPA) HAZARD IDENTIFICATION

NFPA - Health: 1 - Exposure would cause significant irritation, but only minor residual injury.
NFPA - Flammability: 2 - Must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur.
NFPA - Instability: 0 - Normally stable, even under fire conditions, and not reactive with water.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Molecular Weight: 130.23

Conversion Factor:
1 ppm = 5.32 mg/m3; 1 mg/m3 = 0.188 ppm at 25 deg C (calculated)

Physical State: Liquid
Melting Point: -17 to-15 deg C (1.4 to 5 deg F) (26)
Boiling Point: 194.5-195 deg C (382.1-383 deg F) (26)
Relative Density (Specific Gravity): 0.827 at 20 deg C (3,6,16,27); 0.822 at 25 deg C (26) (water = 1)
Solubility in Water: Sparingly soluble (30 mg/100 mL at 20 deg C (4); 58-59 mg/100 mL at 25 deg C (26))
Solubility in Other Liquids: Soluble in all proportions in ethanol, diethyl ether chloroform and mineral oil (3,8); soluble in propylene glycol.(3)
Coefficient of Oil/Water Distribution (Partition Coefficient): Log P(oct) = 3.00 (3,28)
pH Value: Not available
Vapour Density: 4.48 (air = 1) (4)
Vapour Pressure: 0.0087 kPa (0.065 mm Hg) at 20 deg C (calculated-Antoine equation) (8); 0.0106 kPa (0.0794 mm Hg) at 25 deg C (calculated-experimentally derived coefficients) (29)
Saturation Vapour Concentration: 85 ppm (0.008%) at 20 deg C; 104 ppm (0.01%) at 25 deg C (calculated)
Evaporation Rate: Not available
Critical Temperature: 384.9 deg C (724.7 deg F; 658 K) (8)

Other Physical Properties:
VISCOSITY-DYNAMIC: 10.64 mPa.s (10.64 centipoises) at 15 deg C (8); 8.4 mPa.s at 20 deg C (6)
VISCOSITY-KINEMATIC: 10.16 mm2/s (10.16 centistokes) at 20 deg C (calculated)
SAYBOLT UNIVERSAL VISCOSITY: 59.3 Saybolt seconds at 37.8 deg C (100 deg F) (calculated) (30)
SURFACE TENSION: 27.50 mN/m (27.50 dynes/cm) at 20 deg C; 27.10 mN/m (27.10 dynes/cm) at 25 deg C (31)
CRITICAL PRESSURE: 2685.3 kPa (26.5 atm) (3); 3445.3 kPa (34 atm) (8)
DIELECTRIC CONSTANT: 10.34 at 20 deg C (8)
HENRY'S LAW CONSTANT: 2.454 Pa.m3/mol at 25 deg C (experimental) (36); log H = -3.00 (dimensionless constant; calculated)


SECTION 10. STABILITY AND REACTIVITY

Stability:
Normally stable

Hazardous Polymerization:
Does not occur

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.


STRONG OXIDIZING AGENTS (e.g. calcium hypochlorite, chlorine oxides, chromium trioxide, hydrogen peroxide, nitric acid or nitrates) - may react violently or explosively. Increased risk of fire and explosion.(13,32)
HALOGENS (e.g. bromine or chlorine) - reaction may be vigorous or violent, resulting in explosions.(7,32)
PERCHLORIC ACID or METAL PERCHLORATES (e.g. barium perchlorate) - may form shock-sensitive or explosive compounds.(7,32)
ACIDS, ACID ANHYDRIDES, or ACID CHLORIDES - reaction may be vigorous or violent, with the evolution of heat.(13)
LITHIUM ALUMINUM HYDRIDE - reaction may be vigorous.(7)
ISOCYANATES (e.g. toluene diisocyanate, hexamethylene diisocyanate or methyl isocyanate) - may react vigorously, violently or explosively with the generation of heat.(7)
Mixtures or reactions of alcohols with the following materials may cause explosions: acetaldehyde, dialkylmagnesiums, N-haloimides (e.g. N- bromosuccinimide or N-chlorosuccinimide), ethylene oxide, hydrogen peroxide and sulfuric acid, hypochlorous acid, nitrogen tetraoxide, nitryl hypochlorite, permonosulfuric acid and tri-isobutyl aluminum.(7,32)

Hazardous Decomposition Products:
None reported

Conditions to Avoid:
Open flames, heat, temperatures above 81 deg C and other ignition sources.

Corrosivity to Metals:
Octanols are not corrosive to the common metals, such as cast iron, steel, stainless steels, aluminum, copper, brass, bronze, nickel and its alloys, tantalum, titanium and zirconium at least up to 93 deg C.(33)

Stability and Reactivity Comments:
Octanol (isomer not specified) attacks some plastics, such as fluorocarbons, phenolic asbestos, and styrene-acrylonitrile.(34) Like pentanol (isomer not specified), a related alcohol, it may also attack some elastomers and coatings.(35)


SECTION 11. TOXICOLOGICAL INFORMATION

LD50 (oral, rat): greater than 5000 mg/kg (1, citing unpublished study)
Note: an LD50 (oral, rat): greater than 3200 mg/kg has been cited for 1-octanol (1), but is actually for 2-octanol.
LD50 (oral, mouse): 1790 mg/kg (octanol; isomer not specified) (18)

LD50 (dermal, rabbit): greater than 5000 mg/kg (1)

Eye Irritation:

1-Octanol is a moderate irritant.

Application of 0.1 mL of undiluted 1-octanol produced moderate irritation in rabbits (scored 41/110). Average scores at 24, 48 and 72 hours for each of 3 rabbits were: corneal opacity: 2/4, 2/4, 1/4; iris injury: 1/2, 1/2, 0/2; redness: 2.67/3, 2.33/3, 1.67/3; chemosis: 3/4, 2.67/4, 1.67/4. Irritation was still present after 7 days but all scores were 0/110 by day 14.(17) Application of 0.1 mL of 99% 1-octanol caused moderate irritation in rabbits (average scores: redness: 2.54/3; chemosis: 1.83/4; corneal opacity: 2.11/4).(38)

Skin Irritation:

1-Octanol is probably a mild irritant.

Application of 230 microL of octanol (isomer not specified) for 3 hours caused mild skin irritation in hairless rats (scored 0.3/4 for redness).(39) Application of undiluted octanol (isomer not specified) to intact or broken skin produced mild irritation in rabbits.(21, citing unpublished study) In a study, which is not available in English, application of 50% 1-octanol in vaseline caused moderate irritation in rabbits.(37, unconfirmed) There are insufficient details available to evaluate this report.

Effects of Short-Term (Acute) Exposure:

Inhalation:
Mice exposed to 50 ppm (cited as 1000 mg/m3) for 10 minutes experienced a 50% reduction in respiratory rate (RD50).(19) Exposure to this concentration is expected to produce intolerable eye, nose and throat irritation (sensory irritation) in humans. Rats were exposed to 1-octanol vapour generated by heating the chemical to 425 deg C. No deaths were observed in animals exposed to 1200 (cited as 6.39 mg/L) for 1 hour. No lung lesions were noted. Exposure to 1050 ppm (cited as 5.6 mg/L) for 4 hours resulted in the deaths of 3/10 rats. Lung injury (tissue death, fluid accumulation and bleeding) was observed 1-2 days after exposure.(40)

Ingestion:
No effects were observed in mice after oral administration of 179 mg/kg for 1 month.(16, unconfirmed) There are no further details available for evaluation. Aspiration of 0.2 mL 1-octanol caused death in 10/10 rats. Death occurred after a few breaths and was attributed to respiratory or cardiac arrest or both. The lungs showed bleeding and accumulation of fluid (edema).(14)

Carcinogenicity:
1-Octanol appeared to be a weak tumour promoter when applied 3 times/week for 60 weeks to the skin of mice that had been pre-treated with a known carcinogen.(20)

Teratogenicity, Embryotoxicity and/or Fetotoxicity:
The information located does not indicate that 1-octanol is a developmental toxin.
Rats were exposed by inhalation to the maximum vapour concentration attainable (76 ppm (400 mg/m3)) on days 1-19 of pregnancy. No treatment-related effects were observed in the mothers or offspring (frequency of resorptions, fetal weights, or skeletal/visceral malformations).(12) Rats were orally exposed to 0, 130, 650 or 1300 mg/kg/day on days 6-15 or pregnancy. Pronounced maternal toxicity, but no developmental toxicity, was observed.(23)

Mutagenicity:
The limited evidence available does not indicate that 1-octanol is mutagenic. No studies using live animals were located. Positive results were obtained in cultured mammalian cells and negative results were obtained in bacteria.
Positive results (aneuploidy) were obtained in cultured mammalian cells.(10) In an unpublished study, negative results (gene mutation) were obtained in bacteria, with and without metabolic activation.(37, unconfirmed)

Toxicological Synergisms:
1-Octanol has enhanced the skin absorption of melatonin in hairless rats.(39)


SECTION 16. OTHER INFORMATION

Selected Bibliography:
(1) Opdyke, D.L.J. Fragrance raw materials monographs: alcohol C-8. Food and Cosmetics Toxicology. Vol. 11 (1973). p. 95-96, 101-102
(2) Emergency action guide for octanol. Association of American Railroads, March, 1995
(3) HSDB record for 1-octanol. Last revision date: 1998-06-02
(4) Verschueren, K. Handbook of environmental data on organic chemicals. 3rd ed. Van Nostrand Reinhold, 1996. p. 1428-1430
(5) Ruth, J.H. Odor thresholds and irritation levels of several chemical substances: a review. American Industrial Hygiene Association Journal. Vol. 47 (Mar. 1985). p. A 149
(6) Peters, R.A.. Alcohols, higher aliphatic. In: Kirk-Othmer encyclopedia of chemical technology. 4th ed. Vol. 1. John Wiley and Sons, 1992. p. 865- 893
(7) Fire protection guide to hazardous materials. 13th ed. Edited by A.B. Spencer, et al. National Fire Protection Association, 2002. NFPA 325; NFPA 491
(8) Dean, J.A. Lange's handbook of chemistry. 14th ed. McGraw-Hill, Inc., 1992. p. 1.274, 5.51, 5.117, 6.143
(9) 1-Octanol. In: Chemical safety sheets: working safely with hazardous chemicals. Kluwer Academic Publishers, 1991. p. 657
(10) Onfelt, A. Spindle disturbances in mammalian cells: III. Toxicity, c-mitosis and aneuploidy with 22 different compounds: specific and unspecific mechanisms. Mutation Research. Vol. 182, no. 3 (1987). p. 135-154
(11) Scheuplein, R.J., et al. Mechanism of percutaneous absorption. IV. penetration of nonelectrolytes (alcohols) from aqueous solutions and from pure liquids. The Journal of Investigative Dermatology. Vol. 60, no. 5 (1973). p. 286-296
(12) Nelson, B.K., et al. Developmental toxicology of 1-octanol, 1-nonanol, and 1-decanol administered by inhalation to rats. Journal of the American College of Toxicology. Vol. 9, no. 1 (1990). p. 93-97
(13) Sigma-Aldrich Canada Ltd. (URL: http://www.sigma- aldrich.com/saws.nsf/Pages/Main?EditDocument- Password required)
(14) Gerarde, H.W., et al. The aspiration hazard and toxicity of a homologous series of alcohols. Archives of Environmental Health. Vol. 13 (Oct. 1966). p. 457-461
(15) Forsberg, K., et al. Quick selection guide to chemical protective clothing. 4th ed. Van Nostrand Reinhold, 2002
(16a) Lington, A.W. et al. Alcohols: octanols: 1-octanol. In: Patty's industrial hygiene and toxicology. 4th ed. Edited by G.D. Clayton, et al. Vol. II. Toxicology. Part D. John D. Wiley and Sons, 1994. p. 2588-2589, 2676-2678
(16b) Bevan, C. Monohydric alcohols - C7 to C18, aromatic, and other alcohols. In: Patty's toxicology. 5th ed. Edited by E. Bingham et al. Vol. 6, Chpt. 78. John Wiley and Sons, 2001
(17) European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). Eye irritation: reference chemicals data bank. 2nd ed. Technical Report No. 48 (2). European Centre for Ecotoxicology and Toxicology, June 1998. p. 66
(18) Voskoboinikova, V.B. Determination of the maximum permissible concentrations of the flotation agent IM-68 and of its component alcohols (hexyl, heptyl and octyl) in water supplies. Hygiene and Sanitation. Vol. 31, nos. 1-3 (1966). p. 310-316
(19) Muller, J., et al. Recherche de relations entre toxicite de molecules d'interet industriel et proprietes physico-chimiques: test d'irritation des voies aeriennes superieurers applique a quatre familles chimiques. Food Chemistry and Toxicology. Vol. 22, no. 8 (1984). p. 661-664
(20) Sice, J. Tumor-promoting activity of n-alkanes and 1-alkanols. Toxicology and Applied Pharmacology. Vol. 9, no. 1 (1966). p. 70-74
(21) Opdyke, D.L.J. Supplement to earlier monographs on fragrance raw materials. Monographs on Fragrance Raw Materials. Food Cosmetic Toxicology. Vol. 11 (1973). p. 1079-1081
(22) Griffiths, H.A., et al. Interlaboratory evaluation of a human patch test for the identification of skin irritation potential/hazard. Food and Chemical Toxicology. Vol. 35, no. 2 (Feb. 1997). p. 255-260
(23) Hellwig, J., et al. Differential prenatal toxicity of one straight- chain and five branch-chain primary alcohols in rats. Food and Chemical Toxicology. Vol. 35, no. 5 (May 1997). p. 489-500
(24) McLaughlin, R.S. Chemical burns of the human cornea. American Journal of Ophthalmology. Vol. 29, no. 11 (Nov. 1946). p. 1355-1362
(26) Mackay, D., et al. Physical-chemical properties and environmental fate handbooks. (CD-ROM). CRCnetBASE 2000. Chapman and Hall/CRCnet BASE, 2000
(27) Falbe, J., et al. Alcohols, aliphatic. In: Ullmann's encyclopedia of industrial chemistry. 5th completely revised ed. Vol. A 1. VCH Verlagsgesellschaft, 1985. p. 279-303
(28) On-line LogP (octanol/water partition coefficient) database, including experimental data (Interactive LogKow (KowWin)) (URL: http://esc- plaza.syrres.com/interkow/kowdemo.htm)
(29) Daubert, T.E., et al. Physical and thermodynamic properties of pure chemicals: data compilation. Design Institute For Physical Property Data, American Institute Of Chemical Engineers. Hemisphere Publishers Corp., 1989
(30) American Society for Testing and Materials (ASTM) Standard practice for conversion of kinematic viscosity to Saybolt Universal viscosity or to Saybolt Furol viscosity. ASTM Designation: D 2161 -93 (Reapproved 1999). American Society for Testing and Materials, 1999
(31) Jasper, J.J. Surface tension of pure liquid compounds. In: Compilation of data of some 2200 pure liquid compounds. Journal of Physical and Chemical Reference Data. Vol. 1, no. 4 (1972). p. 852
(32) Urben, P.G., ed. Bretherick's reactive chemical hazards database. 6th ed. Version 3.0. Butterworth-Heinemann Ltd., 1999
(33) Corrosion data survey: metals section. 6th ed. National Association of Corrosion Engineers, 1985. p. 92-2 to 93-2
(34) Corrosion data survey: nonmetals section. 5th ed. National Association of Corrosion Engineers, 1983. p. 23 (3-6)
(35) Schweitzer, P.A. Corrosion resistance tables: metals, nonmetals, coatings, mortars, plastics, elastomers and linings, and fabrics. 4th ed. Part A, A-D. Marcel Dekker, Inc., 1995. p. 281-284
(36) Van Thriel, C., et al. Neurobehavioural effects during experimental exposure to 1-octanol and isopropanol. Scandinavian Journal of Work and Environmental Health. Vol. 29, no. 2 (Apr. 2003). p. 143-151
(37) 1-Octanol. IUCLID dataset. European Commission, European Chemicals Bureau, Feb. 2000. Available at: <ecd.jrc.it/IUCLID-Data-Sheet/111875.pdf>
(38) Jacobs, G.A., et al. An objective method for the evaluation of eye irritation in vivo. Food Chemistry and Toxicology. Vol. 27, no. 4 (1989). p. 255-258
(39) Kanikkannan, N., et al. Skin permeation enhancement effect and skin irritation of saturated fatty alcohols. International Journal of Pharmaceutics. Vol. 248 (2002). p. 219-228
(40) IIT Research Institute. Acute inhalation study of 1-octanol vapor in rats and a revised material safety data sheet with cover letter dated 121388. Date produced Dec. 1988. AMOCO Corporation. EPA/OTS 88-890000051. NTIS/OTS0516625-1

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.


Review/Preparation Date: 2001-05-15

Revision Indicators:
Extinguishing media 2003-03-13
Resistance of materials for PPE 2004-04-08
Short-term inhalation 2006-02-13
Short-term skin contact 2006-02-13
Short-term eye contact 2006-02-13
Short-term ingestion 2006-02-13
Mutagenicity 2006-02-13
Synergistic materials 2006-02-13
Toxicological info 2006-02-13
WHMIS detailed classification 2006-02-13
Bibliography 2006-02-13



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