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SECTION 1. CHEMICAL IDENTIFICATION

CHEMINFO Record Number: 465
CCOHS Chemical Name: 2-Methyl-1-pentanol

Synonyms:
Amyl methyl alcohol (non-specific name)
2-Methylamyl alcohol
Methylamyl alcohol (non-specific name)
2-Methylpentanol-1
2-Methyl pentan-1-ol
Methyl pentanol (non-specific name)
2-Methylpentyl alcohol
2-Methyl-2-propylethanol

Chemical Name French: 2-méthylpentane-1-ol
Chemical Name Spanish: 2-metilpentan-1-ol
CAS Registry Number: 105-30-6
UN/NA Number(s): 2282
RTECS Number(s): SA7175000
EU EINECS/ELINCS Number: 203-285-1
Chemical Family: Saturated primary aliphatic alcohol / primary alkanol / primary alkyl alcohol / hexanol / hexyl alcohol
Molecular Formula: C6-H14-O
Structural Formula: CH3-CH2-CH2-CH(CH3)-CH2-OH

SECTION 2. DESCRIPTION

Appearance and Odour:
Colourless liquid (5)

Odour Threshold:
Not available

Warning Properties:
Information not available for evaluation.

Composition/Purity:
2-Methyl-1-pentanol is available in grades of 99% and greater purity. However, commercially the methyl-1-pentanols are rarely used alone, but as a mixture. For example, isohexanol (isohexyl alcohol) contains a mixture of methyl-1-pentanols, as well as 1-hexanol.(6)

Uses and Occurrences:
Pure 2-methyl-1-pentanol is used as a solvent and as a chemical intermediate for plastics and other organic compounds. The isohexanol mixture is used in the production of phthalates and acetates.(4,6)


SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW:
Colourless liquid. COMBUSTIBLE LIQUID AND VAPOUR. Mild central nervous system depressant. High vapour or mist concentrations may cause headache, nausea, dizziness, and drowsiness. EYE IRRITANT. Causes severe eye irritation. Aspiration hazard. Swallowing or vomiting of the liquid may cause aspiration (breathing) into the lungs.



POTENTIAL HEALTH EFFECTS

Effects of Short-Term (Acute) Exposure

Inhalation:
The vapour or mist can probably cause irritation of the nose and throat. Symptoms of central nervous system (CNS) depression such as headaches, nausea, dizziness, and drowsiness may also occur.
There is no specific information available for 2-methyl-1-pentanol, but these are effects reported for other alcohols (n-butyl alcohol and mixed pentanol isomers).

Skin Contact:
The liquid is a mild skin irritant, based on animal information.
Skin absorption can occur to a slight extent.

Eye Contact:
The liquid is a severe eye irritant, based on animal information. The vapour can probably cause eye irritation, based on comparison to related alcohols.

Ingestion:
Like other alcohols, 2-methyl-1-pentanol can probably cause effects resembling "alcohol" intoxication such as headache, dizziness, confusion, nausea and vomiting. In severe cases, unconsciousness may occur.
2-Methyl-1-pentanol may be aspirated into the lungs during ingestion or vomiting, based on its viscosity and surface tension, and comparison to related alcohols. Severe lung injury with edema (accumulation of fluid in the lungs), respiratory arrest and death may result.
Ingestion is not a typical route of occupational exposure.

Effects of Long-Term (Chronic) Exposure

Long-term exposure is not expected to cause any problems which are not also caused by short-term exposure.

Skin:
Repeated or prolonged exposure to liquid can cause dermatitis (dry, red, cracked, thickened skin).

Carcinogenicity:

No human or animal information was located.

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical.

The American Conference of Governmental Industrial Hygienists (ACGIH) has no listing for this chemical.

The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens.

Teratogenicity and Embryotoxicity:
No human or animal information was located.

Reproductive Toxicity:
No human or animal information was located.

Mutagenicity:
No information was located.

Toxicologically Synergistic Materials:
Alcohols may interact synergistically with chlorinated solvents (e.g. carbon tetrachloride) aromatic hydrocarbons (e.g. xylene) or dithiocarbamates (e.g. disulfirams).

Potential for Accumulation:
Probably does not accumulate. Primary alcohols are broken down in the body and excreted.


SECTION 4. FIRST AID MEASURES

Inhalation:
If symptoms are experienced, remove source of contamination or move victim to fresh air. Obtain medical advice.

Skin Contact:
Remove contaminated clothing, shoes and leather goods (e.g. watchbands, belts). Flush with lukewarm, gently flowing water for 5 minutes. If irritation persists, repeat flushing. Obtain medical advice. Completely decontaminate clothing, shoes and leather goods before re-use or discard.

Eye Contact:
Immediately flush the contaminated eye(s) with lukewarm, gently flowing water for 15-20 minutes, while holding the eyelid(s) open. If a contact lens is present, DO NOT delay irrigation or attempt to remove the lens. Take care not to rinse contaminated water into the unaffected eye or onto the face. Immediately obtain medical attention.

Ingestion:
NEVER give anything by mouth if victim is rapidly losing consciousness, is unconscious or convulsing. Have victim rinse mouth thoroughly with water. DO NOT INDUCE VOMITING. If vomiting occurs naturally, have victim lean forward to reduce risk of aspiration. Have victim rinse mouth with water again. Immediately obtain medical attention.

First Aid Comments:
Provide general supportive measures (comfort, warmth, rest).
Consult a doctor and/or the nearest Poison Control Centre for all exposures except minor instances of inhalation or skin contact.
All first aid procedures should be periodically reviewed by a doctor familiar with the material and its conditions of use in the workplace.



SECTION 5. FIRE FIGHTING MEASURES

Flash Point:
54 deg C (129 deg F) (closed cup) (7)

Lower Flammable (Explosive) Limit (LFL/LEL):
1-1.1% (5,7)

Upper Flammable (Explosive) Limit (UFL/UEL):
9.65% (7)

Autoignition (Ignition) Temperature:
310 deg C (590 deg F) (7)

Sensitivity to Mechanical Impact:
Probably not sensitive. Stable material.

Sensitivity to Static Charge:
2-Methyl-1-pentanol will probably not accumulate static charge based on comparison to the closely related alcohol, 1-hexanol, which has a high electrical conductivity. 2-Methyl-1-pentanol vapour will not be ignited by a static discharge at room temperature due to its relatively high flash point.

Electrical Conductivity:
Not available.

Combustion and Thermal Decomposition Products:
Carbon monoxide, carbon dioxide and other irritant gases, which may include unburned alcohol and toxic constituents.

Fire Hazard Summary:
Combustible liquid. Can form explosive mixtures with air. During a fire, irritating/toxic smoke and fumes may be generated. Closed containers may rupture violently and suddenly release large amounts of product when exposed to fire or excessive heat for a sufficient period of time.

Extinguishing Media:
Carbon dioxide, dry chemical powder, appropriate foam, water spray or fog. Special multipurpose, alcohol resistant fire-fighting foams are recommended for use with any polar combustible liquid that is slightly soluble in water, like 2-methyl-1-pentanol.(7) Fire fighting foam manufacturers should be consulted for recommendations regarding types of foams and application rates.

Fire Fighting Instructions:
Evacuate area and fight fire from a safe distance or protected location. Approach fire from upwind to avoid toxic decomposition products.
If possible, isolate materials not yet involved in the fire, and move containers from the fire area if this can be done without risk, and protect personnel. Closed containers may rupture violently when exposed to the heat of a fire. Therefore, fire-exposed containers or tanks should be cooled by application of hose streams. Application should begin as soon as possible (within the first several minutes) and should concentrate on any unwetted portions of the container. Apply water from the side and from a safe distance until well after the fire is out. Stay away from ends of tanks, involved in the fire, but be aware that flying material from ruptured tanks may travel in any direction. Withdraw immediately in case of rising sound from venting safety device or any discolouration of tank due to fire. Cooling should continue until well after the fire is out. If this is not possible, use unmanned monitor nozzles and immediately evacuate the area.
If a leak or spill has not ignited, use water spray in large quantities to disperse the vapours and to protect personnel attempting to stop a leak. Water spray can be used to flush spills away from ignition sources and to dilute spills to non-flammable mixtures. Solid streams of water may be ineffective and spread material.
For an advanced or massive fire in a large area, use unmanned hose holder or monitor nozzles; if this is not possible withdraw from fire area and allow fire to burn.
Tanks or drums should not be approached directly after they have been involved in a fire, until they have been completely cooled down.

Protection of Fire Fighters:
2-Methyl-1-pentanol is slightly hazardous to health. Firefighters may enter the area if positive pressure self-contained breathing apparatus (NIOSH approved or equivalent) and full Bunker Gear is worn.



NATIONAL FIRE PROTECTION ASSOCIATION (NFPA) HAZARD IDENTIFICATION

NFPA - Health: 2 - Intense or continued (but not chronic) exposure could cause temporary incapacitation or possible residual injury.
NFPA - Flammability: 2 - Must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur.
NFPA - Instability: 0 - Normally stable, even under fire conditions, and not reactive with water.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Molecular Weight: 102.17

Conversion Factor:
1 ppm = 4.17 mg/m3; 1 mg/m3 = 0.24 ppm at 25 deg C (calculated)

Physical State: Liquid
Melting Point: Not available
Boiling Point: 148 deg C (298.4 deg F) (8,9)
Relative Density (Specific Gravity): 0.824-0.826 at 20 deg C (8,13,18); 0.821 at 25 deg C (13) (water = 1)
Solubility in Water: Slightly soluble (310 mg/100 g of water at 20 deg C (8,13); 600 mg/100 mL at 25 deg C (19))
Solubility in Other Liquids: Soluble in ethanol, diethyl ether, acetone and carbon tetrachloride (18)
Coefficient of Oil/Water Distribution (Partition Coefficient): No measured values are available. Estimated value: Log P(oct) = 1.75 (11)
pH Value: Not available. Alcohols are both weak acids and weak bases.
Viscosity-Dynamic: 6.6 mPa.s (6.6 centipoises) at 20 deg C (8)
Viscosity-Kinematic: 8.0 mm2/s (8 centistokes) at 20 deg C (calculated)
Saybolt Universal Viscosity: 52.0 Saybolt seconds at 37.8 deg C (100 deg F) (calculated) (13)
Surface Tension: 25.34 mN/m (25.34 dynes/cm) at 20 deg C (calculated) (10)
Vapour Density: 3.53 (air = 1) (calculated)
Vapour Pressure: 0.256 kPa (1.92 mm Hg) at 25 deg C (from experimentally-derived coefficients).(5,12) Also reported as 0.13 kPa (0.97 mm Hg) at 20 deg C; 0.196 kPa (1.47 mm Hg) at 25 deg C (calculated).(20)
Saturation Vapour Concentration: 1300 ppm (0.13%) at 20 deg C; 1900 ppm (0.19%) at 25 deg C; 2525 ppm (0.25%) at 25 deg C (calculated)
Evaporation Rate: Not available
Henry's Law Constant: 4.36 Pa.m3/mol (cited as 4.3 x 10(-5) atm.m3/mol) at 25 deg C (estimated) (19); log H = -2.75 (dimensionless constant; calculated)

SECTION 10. STABILITY AND REACTIVITY

Stability:
Normally stable

Hazardous Polymerization:
Does not occur

Incompatibility - Materials to Avoid:

NOTE: Chemical reactions that could result in a hazardous situation (e.g. generation of flammable or toxic chemicals, fire or detonation) are listed here. Many of these reactions can be done safely if specific control measures (e.g. cooling of the reaction) are in place. Although not intended to be complete, an overview of important reactions involving common chemicals is provided to assist in the development of safe work practices.


STRONG OXIDIZING AGENTS (e.g. calcium hypochlorite, chlorine oxides, chromium trioxide, hydrogen peroxide, nitric acid or nitrates) - may react violently or explosively. Increased risk of fire and explosion.(7,14)
HALOGENS (e.g. bromine or chlorine) - reaction may be vigorous or violent, resulting in explosions.(7,14)
PERCHLORIC ACID or METAL PERCHLORATES (e.g. barium perchlorate) - may form shock-sensitive or explosive compounds.(7,14)
ACIDS, ACID ANHYDRIDES, or ACID CHLORIDES - reaction may be vigorous or violent, with the evolution of heat.
LITHIUM ALUMINUM HYDRIDE - reaction may be vigorous.(7)
ISOCYANATES (e.g. toluene diisocyanate, hexamethylene diisocyanate or methyl isocyanate) - may react vigorously, violently or explosively with the generation of heat.(7)
Mixtures or reactions of alcohols with the following materials may cause explosions: acetaldehyde, dialkylmagnesiums, N-haloimides (e.g. N- bromosuccinimide or N-chlorosuccinimide), ethylene oxide, hydrogen peroxide and sulfuric acid, hypochlorous acid, nitrogen tetraoxide, nitryl hypochlorite, permonosulfuric acid and tri-isobutyl aluminum.(7,14)

Hazardous Decomposition Products:
None reported

Conditions to Avoid:
Open flames, heat and other ignition sources.

Corrosivity to Metals:
No specific information is available for 2-methyl-1-pentanol. The related alcohols, hexanol (isomer not specified) and tert-hexanol, are not corrosive to the common metals, such as stainless steel (e.g. 300 series and 400 series), aluminum (e.g. types 3003 and Cast B-356), carbon steel (e.g. types 1010, 1020 and 1075), cast iron (e.g. gray, ductile and high nickel), nickel, nickel-base alloys, Monel, Hastelloy, copper, brass, bronze, tantalum, titanium and zirconium at least up to 93 deg C.(15,21)

Corrosivity to Non-Metals:
There is no specific information available for 2-methyl-1-pentanol. The related alcohols, 1-hexanol and tert-hexanol, attack some plastics, like acrylonitrile-butadiene-styrene (ABS), polyethylene and fiberglass, styrene-acrylonitrile (SAN) and riged polyurethane; and elastomers like butyl rubber, neoprene, polyacrylate and polyurethane.(16,17) 1-Hexanol and tert-hexanol do not attack plastics, like Teflon and other fluorocarbons, e.g. polyvinylidene fluoride (Kynar), polyvinyl chloride (PVC), chlorinated polyvinyl chloride (CPVC), polypropylene, nylon and high-density polyethylene; and elastomers, like Teflon, Viton and other fluorocarbons, like Chemraz, nitrile Buna N (NBR), styrene-butadiene (SBR), isoprene, natural rubber, fluorosilicone, low-density polyethylene and ethylene vinyl acetate (EVA).(16,17,22,23)


SECTION 11. TOXICOLOGICAL INFORMATION

LD50 (oral, rat): 1410 mg/kg (1)

LD50 (dermal, rabbit): 2940 mg/kg (cited as 3.56 mL/kg) (1)

Eye Irritation:

2-Methyl-1-pentanol is a severe eye irritant.

Application of in excess of a 15% solution caused severe injury in rabbits (scored over 5 where 5 is severe injury, graded 8/10).(1) Application of 0.1 mL of 100% 2-methyl-1-pentanol produced mild irritation in rabbits (average scores at 24, 48 and 72 hours for each of 3 rabbits: corneal opacity: 1.67/4, 1/4, 0.67/4; iris injury: 0/2, 0/2, 0/2; redness: 1.67/3, 1/3, 0.67/3; chemosis: 1/4, 0.67/4, 0.33/4). All scores were 0 by day 7.(2) Application of 750 ug for 24 hours in a standard Draize test produced severe irritation in rabbits.(3-unconfirmed)

Skin Irritation:

2-Methyl-1-pentanol is a mild skin irritant.

Application of 100% produced no irritation in rabbits (graded 1/10).(1) Application of 500 mg for 24 hours in a standard Draize test produced mild irritation in rabbits.(3-unconfirmed)

Effects of Short-Term (Acute) Exposure:

Inhalation:
Inhalation of concentrated vapours for 8 hours produced no deaths in rats.(1)


SECTION 16. OTHER INFORMATION

Selected Bibliography:
(1) Smyth, H.F. Jr., et al. Range-finding toxicity data: List V. Archives of Industrial Hygiene and Occupational Medicine. Vol. 10 (1954). p. 61-62, 67-68
(2) European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). Eye irritation: reference chemicals data bank. 2nd ed. Technical Report No. 48 (2). European Centre for Ecotoxicology and Toxicology, June 1998. p. 60
(3) MDL Information Systems, Inc. 1-pentanol, 2-methyl. Last updated: 2000-07. In: Registry of Toxic Effects of Chemical Substances (RTECS(R)). [CD-ROM]. Canadian Centre for Occupational Health and Safety (CCOHS). Also available at: <ccinfoweb.ccohs.ca/rtecs/search.html> {Subscription required}
(4) Lewis, Sr., R.J., ed. 2-Methyl-1-pentanol. Hawley's condensed chemical dictionary. [CD-ROM]. 14th ed. John Wiley and Sons, Inc., 2002
(5) Yaws, C.L. Handbook of chemical compound data for process safety: comprehensive safety and health-related data for hydrocarbons and organic chemicals: selected data for inorganic chemicals. Library of physico-chemical property data. Gulf Publishing Company, 1997. p. 14, 40, 67, 95
(6) Bevan, C. Monohydric alcohols - C1 to C6: methyl-1-pentanols. In: Patty's toxicology. 5th ed. Edited by E. Bingham, et al. Vol. 6. John Wiley and Sons, 2001. p. 366, 445-446
(7) Fire protection guide to hazardous materials. 13th ed. Edited by A.B. Spencer, et al. National Fire Protection Association, 2002. NFPA 325; NFPA 491 (Alcohols)
(8) Kenneally, C.J. Alcohols, higher aliphatic, survey and natural alcohols manufacture. In: Kirk-Othmer encyclopedia of chemical technology. John Wiley and Sons, 2005. Available at: <www.mrw.interscience.wiley.com/kirk/kirk_search_fs.html> {Subscription required}
(9) Falbe, J. et al. Alcohols, aliphatic. In: Ullmann's encyclopedia of industrial chemistry. 7th ed. John Wiley and Sons, 2005. Available at: <www.mrw.interscience.wiley.com/ueic/ueic_search_fs.html> {Subscription required}
(10) Dean, J.A. Lange's handbook of chemistry. 15th ed. McGraw-Hill, Inc., 1999. p.1.274, 5.50, 5.100
(11) Syracuse Research Corporation. Interactive LogKow (KowWin) Database Demo. Date unknown. Available at: <syrres.com/esc/kowdemo.htm>
(12) Daubert, T.E., et al. Physical and thermodynamic properties of pure chemicals: data compilation. Design Institute For Physical Property Data, American Institute Of Chemical Engineers. Hemisphere Publishers Corp., 1989
(13) Riddick, J.A., et al. Organic solvents: physical properties and methods of purification. 4th ed. Techniques of organic chemistry. Vol. II. John Wiley and Sons, 1986. p. 220, 894
(14) Bretherick's reactive chemical hazards database. [CD-ROM]. 6th ed. Version 3.0. Edited by P.G. Urben. Butterworth-Heinemann Ltd., 1999
(15) Corrosion data survey: metals section. 6th ed. National Association of Corrosion Engineers, 1985. p. 12-14 to 13-14
(16) Corrosion data survey: nonmetals section. 5th ed. National Association of Corrosion Engineers, 1983. p. 19 (1-6)
(17) Schweitzer, P.A. Corrosion resistance tables: metals, nonmetals, coatings, mortars, plastics, elastomers and linings, and fabrics. 4th ed. Part B, E-O. Marcel Dekker, Inc., 1995. p. 1445-1448
(18) Handbook of chemistry and physics. [CD-ROM]. Edited by D.R. Lide. Chapman and Hall/CRCnetBASE, 1999
(19) Syracuse Research Corporation. 2-Methyl-1-pentanol. In: The Physical Properties Database (PHYSPROP). Interactive PhysProp Database Demo. Date unknown. Available at: <www.syrres.com/esc/physdemo.htm>
(20) Thomas, L.H., et al. Vapor pressures and molar entropies of vaporization of monohydric alcohols. Journal of Chemical and Engineering Data. Vol. 24, no. 3 (1979). p. 159-161
(21) Pruett, K.M. Chemical resistance guide to metals and alloys: a guide to chemical resistance of metals and alloys. Compass Publications, 1995. p. 158-169
(22) Pruett, K.M. Chemical resistance guide for plastics: a guide to chemical resistance of engineering thermoplastics, fluoroplastics, fibers and thermoset resins. Compass Publications, 2000. p. 230-241
(23) Pruett, K.M. Chemical resistance guide for elastomers II: a guide to chemical resistance of rubber and elastomeric compounds. Compass Publications, 1994. p. C-182 to C-187
(24) National Institute for Occupational Safety and Health (NIOSH). Alcohols III. In: NIOSH Manual of Analytical Methods (NMAM(R)). 4th ed. Edited by M.E. Cassinelli, et al. DHHS (NIOSH) Publication 94-113. Aug. 1994. Available at: <www.cdc.gov/niosh/nmam/nmammenu.html>

Information on chemicals reviewed in the CHEMINFO database is drawn from a number of publicly available sources. A list of general references used to compile CHEMINFO records is available in the database Help.


Review/Preparation Date: 2005-07-03



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