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International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 12 (1976) (p. 37)

CAS No.: 63-25-2
Chem. Abstr. Name: Methylcarbamate 1-naphthalenol

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

In one study in rats with relatively low survival rates, carbaryl produced sarcomas following its oral but not after its subcutaneous administration. In one study in mice by oral administration, no carcinogenic effect was observed. The available data do not allow an evaluation of the carcinogenicity of carbaryl to be made.

Carbaryl can react with nitrite under mildly acid conditions, simulating those in the human stomach, to give rise to N-nitrosocarbaryl, which has been shown to be carcinogenic in rats (see also 'General Remarks on Carbamates, Thiocarbamates and Carbazides', in this volume).

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 59: Group 3)

For definition of Groups, see Preamble Evaluation.


Last updated: 25 March 1998

See Also:
        Carbaryl (EHC 153, 1994)
        Carbaryl (ICSC)
        Carbaryl (PDS)
        Carbaryl (PIM 147)