International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 30 (1983) (p. 295)
CAS No.: l33-06-2
Chem. Abstr. Name: 1H-Isoindole-l,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-[(trichloromethyl)thio]-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Captan was tested for carcinogenicity in mice and rats by
administration in the diet. It was carcinogenic to one strain of
mice, inducing duodenal tumours (adenocarcinoma and adenomatous
polyp). No evidence of carcinogenicity was found in rats.
Captan has shown little, if any, embryotoxic or teratogenic
potential in mice or rats at maternally tolerated doses. Results
obtained in tests with rabbits and hamsters were considered
Captan was mutagenic to bacteria and yeast. Both positive and
negative results were obtained in the host-mediated assay in mice.
Weak or negative effects were observed in Drosophila melanogaster.
Captan induced chromosomal aberrations, sister chromatid exchange and
mutations at several loci, but not unscheduled DNA synthesis, in
cultured mammalian cells. No increase in micronucleated erythrocytes
or chromosomal aberrations was detected in treated mice or rats;
positive results obtained in dominant lethal tests in mice and rats
were not confirmed by other studies. Thus, there is sufficient
evidence to establish the mutagenicity of captan in cellular systems,
but the data were insufficient to establish its mutagenicity in
5.2 Human data
Captan was introduced commercially in 1951. Its production,
formulation and use as a fungicide in agricultural and industrial
applications and in cosmetics are potential sources of exposure, both
of workers and of the general population.
No data were available to evaluate the teratogenic or chromosomal
effects of captan in humans.
No case report or epidemiological study of the carcinogenicity of
captan alone was available to the Working Group. (See, however, the
section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators
and Users', in this volume.)
Results of the experiments in mice provide limited evidence that
captan is carcinogenic to experimental animals. No data on humans
The available data are insufficient to evaluate the
carcinogenicity of captan to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 59: Group 3)
- Agrosol S
- Agrox 2-Way and 3-Way
- Bean Seed Protectant
- Captaf, Captan 50W
- Captan-Streptomycin 7.5-0.l Potato Seed Piece Protectant
- ENT 26538
- Esso Fungicide 406
- Flit 406
- Fungus Ban Type II
- Glyodex 37-22
- Granox PFM
- Gustafson Captan 30-DD
- Isotox Seed Treater "D" and "F"
- Micro-Check 12
- Orthocide 7.5, 50, 75 & 83
- SR 406
- Stauffer Captan
- 3a,4,7,7a-Tetrahydro-N-(trichloromethanesulphenyl) phthalimide
- N-[(Trichloromethyl)thio]-4-cyclohexene-1,2- dicarboximide
- N-(Trichloromethylthio)-cyclohex-4-ene-1,2- dicarboximide
- Vancide P-75, 89 and 89 RE
- Vangard K
- Vanguard K
Last updated: 16 April 1998
Captan (PIM 098)