VOL.: 41 (1986) (p. 293)
Dietary exposure of breeding pairs of rats to amitrole reduces growth and viability of offspring.
Amitrole does not induce DNA damage in bacteria but may have an effect in yeast. It is not mutagenic to Salmonella typhimurium or Escherichia coli. Amitrole induces aneuploidy in yeast, but not mutation in yeast or Aspergillus nidulans. However, conflicting results were obtained in assays for mitotic gene conversion and recombination. It is weakly mutagenic to Streptomyces coelicolor. It does not induce sex-linked recessive lethal mutations or nondisjunction in Drosophila melanogaster. Amitrole induced mutations at two loci in one mammalian cell line. Amitrole does not induce unscheduled DNA synthesis in hepatocytes of rats exposed in vivo. No aneuploidy or chromosomal aberration is found in cultured human lymphocytes. Micronuclei are not induced in mouse bone marrow. Cell transformation is induced in mammalian cells. A commercial preparation of amitrole induces chromosomal abnormalities in plants.
No data were available to evaluate the reproductive effects or prenatal toxicity of amitrole to humans.
In a small cohort study of Swedish railroad workers who had sprayed herbicides, there was a statistically significant excess of all cancers among those exposed to both amitrole and chlorophenoxy herbicides, but not among those exposed mainly to amitrole.
There is inadequate evidence for the carcinogenicity of amitrole to humans.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 7 (1974)
Subsequent evaluations: Suppl. 7 (1987); Vol. 79 (2001)
See Also: Amitrole (EHC 158, 1994) Amitrole (IARC Summary & Evaluation, Supplement 7, 1987) Amitrole (IARC Summary & Evaluation, Volume 7, 1974) Amitrole (ICSC) Amitrole (PDS) Amitrole (PIM 648)