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International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 7 (1974) (p. 31)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Amitrole induced thyroid and liver tumours in both mice and rats following oral and/or subcutaneous administration. An increased incidence of liver-cell tumours in the trout has also been reported following oral administration, but this cannot be considered as conclusive until additional studies using properly controlled diets are reported. Limited skin-painting studies in mice gave no evidence of skin carcinogenicity.

5.2 Human carcinogenicity data

A single, small, cohort study raises the suspicion that amitrole may be carcinogenic to man, but the findings cannot be regarded as conclusive.

Subsequent evaluations: Vol. 41 (1986); Suppl. 7 (1987); Vol. 79 (2001)

Last updated: 20 March 1998

See Also:
        Amitrole (EHC 158, 1994)
        Amitrole (IARC Summary & Evaluation, Supplement 7, 1987)
        Amitrole (IARC Summary & Evaluation, Volume 41, 1986)
        Amitrole (ICSC)
        Amitrole (PDS)
        Amitrole (PIM 648)