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ACETONITRILE ICSC: 0088
Date of Peer Review: March 2002

Methyl cyanide
Cyanomethane
Ethanenitrile
Methanecarbonitrile
CAS # 75-05-8 C2H3N / CH3CN
RTECS # AL7700000 Molecular mass: 41.0
UN # 1648
EC # 608-001-00-3
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking. NO contact with oxidants.
Alcohol-resistant foam, dry powder, carbon dioxide.
EXPLOSION Vapour/air mixtures are explosive. Risk of fire and explosion on contact with oxidants.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
STRICT HYGIENE!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Sore throat. Weakness. Abdominal pain. Laboured breathing. Convulsions. Unconsciousness. Vomiting. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin Redness.
Protective gloves.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
Eyes Redness. Pain.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion (See Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give plenty of water to drink. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Ventilation. Remove all ignition sources. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. Personal protection: complete protective clothing including self-contained breathing apparatus.
EU Classification
Symbol: F, Xn
R: 11-20/21/22-36
S: (1/2-)-16-36/37
UN Classification
UN Hazard Class: 3
UN Pack Group: II
EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30S1648
NFPA Code: H 2; F 3; R 0;
Fireproof. Separated from acids, bases and oxidants. Cool. Well closed.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2004

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ACETONITRILE ICSC: 0088
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID, WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The vapour mixes well with air, explosive mixtures are easily formed.

CHEMICAL DANGERS:
The substance decomposes on burning producing toxic fumes including hydrogen cyanide and nitrogen oxides. Reacts with aqueous acids and bases producing toxic fumes. Reacts with strong oxidants causing fire and explosion hazard. Attacks some forms of plastic, rubber and coatings.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 20 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK: 20 ppm, 34 mg/m; Peak limitation category: II(2); skin absorption (H); Pregnancy risk group: C; (DFG 2004).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes, the skin and the respiratory tract. The substance may cause effects on the cellular respiration (inhibition), resulting in convulsions and respiratory failure. Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated.

PHYSICAL PROPERTIES
Boiling point: 82C
Melting point: -46C
Relative density (water = 1): 0.8
Solubility in water: miscible
Vapour pressure, kPa at 20C: 9.7
Relative vapour density (air = 1): 1.4
Relative density of the vapour/air-mixture at 20C (air = 1): 1.04
Flash point: 12.8C c.c.
Auto-ignition temperature: 524C
Explosive limits, vol% in air: 3.0-16
Octanol/water partition coefficient as log Pow: -0.3
ENVIRONMENTAL DATA

NOTES
The symptoms of acute intoxication do not become manifest until after a few hours. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Card has been partly updated in April 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2004
See Also:
        Acetonitrile (CHEMINFO)
        Acetonitrile (EHC 154, 1993)