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ACETIC ANHYDRIDE ICSC: 0209
Date of peer-review: September 1993

Acetic acid, anhydride
Acetic oxide
Ethanoic anhydride
Acetyl oxide
CAS # 108-24-7 C4H6O3/(CH3CO)2O
RTECS # AK1925000 Molecular mass: 102.1
UN # 1715
EC # 607-008-00-9
TYPES OF HAZARD / EXPOSURE ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE FIGHTING
FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking.
Alcohol-resistant foam, powder, carbon dioxide (see Notes).
EXPLOSION Above 49C explosive vapour/air mixtures may be formed.
Above 49C use a closed system, ventilation, and explosion-proof electrical equipment.
In case of fire: cool drums, etc., by spraying with water but avoid contact of the substance with water.
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
Inhalation Corrosive. Cough. Laboured breathing. Shortness of breath. Sore throat. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer for medical attention.
Skin Corrosive. Redness. Pain. Blisters.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
Eyes Corrosive. Redness. Pain. Severe deep burns.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion Corrosive. Abdominal pain. Sore throat. Collapse.
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Consult an expert! Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT absorb in saw-dust or other combustible absorbents (extra personal protection: self-contained breathing apparatus).
Airtight. Do not transport with food and feedstuffs.
EU Classification
Symbol: C
R: 10-34
S: (1/2-)26-45
UN Classification
UN Hazard Class: 8
UN Subsidiary Risks: 3
UN Pack Group: II
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-63 NFPA Code: H 2; F 2; R 1; W
Fireproof. Separated from food and feedstuffs, incompatible substances (see Chemical Dangers). Dry.
IPCS
International
Programme on
Chemical Safety
Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities IPCS, CEC 2001

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ACETIC ANHYDRIDE ICSC: 0209
IMPORTANT DATA
PHYSICAL STATE; APPEARANCE:
COLOURLESS, VERY MOBILE LIQUID , WITH PUNGENT ODOUR.

CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes and gases including acetic acid. Reacts violently with boiling water, steam, strong oxidants, alcohols, amines, strong bases, and many other compounds. Attacks many metals in presence of water. The liquid is very corrosive, especially in presence of water or moisture (further see Notes).

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 5 ppm; 21 mg/m^3 (as TWA) (ACGIH 1993-1994).
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
Corrosive. Tear drawing. The substance is corrosive to the eyes, the skin and the respiratory tract. Inhalation of the vapour may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis.
PHYSICAL PROPERTIES
Boiling point: 139C
Melting point: -73C
Relative density (water = 1): 1.08
Solubility in water: Reaction
Vapour pressure, kPa at 20C: 0.5
Relative vapour density (air = 1): 3.5
Relative density of the vapour/air-mixture at 20C (air = 1): 1.01
Flash point: 49C c.c.
Auto-ignition temperature: 316C
Explosive limits, vol% in air: 2.7-10.3
ENVIRONMENTAL DATA

NOTES
Forms acetic acid when mixed with water. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered. Major fires must be extingushed with large amounts of water from a distance.
ADDITIONAL INFORMATION


LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information
IPCS, CEC 2001

See Also:
        Acetic anhydride (CHEMINFO)